1. t1dm 2. absence of confirmation of covid-19 infection 3. age \<21 years 4. presence of heart failure (lvef\<40%) or a history of hospitalization for heart failure 5. use of diuretics (furosemide or aldactone) for heart disease usually for heart failure. patients with hypertension receiving diuretic therapy (usually thiazide) will be included in the study 6. patient on mechanical ventilation or patients whose clinical condition requires mechanical ventilation in the following 24 hours. 7. patients not expected to survive \> 48 hours 8. patients receiving pioglitazone for the management of their diabetes 9. patients participating in other research study will be excluded 10. pregnant women will be excluded from the study

1. t1dm 2. absence of confirmation of covid-19 infection 3. age \<21 years 4. presence of heart failure (lvef\<40%) or a history of hospitalization for heart failure 5. use of diuretics (furosemide or aldactone) for heart disease usually for heart failure. patients with hypertension receiving diuretic therapy (usually thiazide) will be included in the study 6. patient on mechanical ventilation or patients whose clinical condition requires mechanical ventilation in the following 24 hours. 7. patients not expected to survive \> 48 hours 8. patients receiving pioglitazone for the management of their diabetes 9. patients participating in other research study will be excluded 10. pregnant women will be excluded from the study

t1dm absence of confirmation of covid-19 infection age <21 years presence of heart failure (lvef<40%) or a history of hospitalization for heart failure use of diuretics (furosemide or aldactone) for heart disease usually for heart failure. patients with hypertension receiving diuretic therapy (usually thiazide) will be included in the study patient on mechanical ventilation or patients whose clinical condition requires mechanical ventilation in the following 24 hours. patients not expected to survive > 48 hours patients receiving pioglitazone for the management of their diabetes patients participating in other research study will be excluded pregnant women will be excluded from the study

t1dm absence of confirmation of covid-19 infection age <21 years presence of heart failure (lvef<40%) or a history of hospitalization for heart failure use of diuretics (furosemide or aldactone) for heart disease usually for heart failure. patients with hypertension receiving diuretic therapy (usually thiazide) will be included in the study patient on mechanical ventilation or patients whose clinical condition requires mechanical ventilation in the following 24 hours. patients not expected to survive > 48 hours patients receiving pioglitazone for the management of their diabetes patients participating in other research study will be excluded pregnant women will be excluded from the study

1. t1dm 2. absence of confirmation of covid-19 infection 3. age <21 years 4. presence of heart failure (lvef<40%) or a history of hospitalization for heart failure 5. use of diuretics (furosemide or aldactone) for heart disease usually for heart failure. patients with hypertension receiving diuretic therapy (usually thiazide) will be included in the study 6. patient on mechanical ventilation or patients whose clinical condition requires mechanical ventilation in the following 24 hours. 7. patients not expected to survive > 48 hours 8. patients receiving pioglitazone for the management of their diabetes 9. patients participating in other research study will be excluded 10. pregnant women will be excluded from the study

1. t1dm 2. absence of confirmation of covid-19 infection 3. age <21 years 4. presence of heart failure (lvef<40%) or a history of hospitalization for heart failure 5. use of diuretics (furosemide or aldactone) for heart disease usually for heart failure. patients with hypertension receiving diuretic therapy (usually thiazide) will be included in the study 6. patient on mechanical ventilation or patients whose clinical condition requires mechanical ventilation in the following 24 hours. 7. patients not expected to survive > 48 hours 8. patients receiving pioglitazone for the management of their diabetes 9. patients participating in other research study will be excluded 10. pregnant women will be excluded from the study