key inclusion criteria: 1. provide written informed consent prior to performing study procedures 2. hospitalized. 3. male or female ≥18 years of age 4. positive for severe acute respiratory syndrome coronavirus 2 5. presence of symptoms of lower respiratory tract infection (lrti) including at least 1 of the following: fever, cough, sore throat, malaise, headache, muscle pain, or more significant lower respiratory tract symptoms, including shortness of breath 6. at least 1 of the following: respiratory rate (rr) ≥20 breaths per minute, room air oxygen saturation (spo2) \<98%, requirement for supplemental oxygen, heart rate (hr) ≥90 beats per minute, or temperature \>38.3°c 7. women of childbearing potential must agree to abstinent or use at least 1 form of contraception not including hormonal contraception from the day of screening through day 30 key

key inclusion criteria: 1. provide written informed consent prior to performing study procedures 2. hospitalized. 3. male or female ≥18 years of age 4. positive for severe acute respiratory syndrome coronavirus 2 5. presence of symptoms of lower respiratory tract infection (lrti) including at least 1 of the following: fever, cough, sore throat, malaise, headache, muscle pain, or more significant lower respiratory tract symptoms, including shortness of breath 6. at least 1 of the following: respiratory rate (rr) ≥20 breaths per minute, room air oxygen saturation (spo2) \<98%, requirement for supplemental oxygen, heart rate (hr) ≥90 beats per minute, or temperature \>38.3°c 7. women of childbearing potential must agree to abstinent or use at least 1 form of contraception not including hormonal contraception from the day of screening through day 30 key

key inclusion criteria: provide written informed consent prior to performing study procedures hospitalized. male or female ≥18 years of age positive for severe acute respiratory syndrome coronavirus 2 presence of symptoms of lower respiratory tract infection (lrti) including at least 1 of the following: fever, cough, sore throat, malaise, headache, muscle pain, or more significant lower respiratory tract symptoms, including shortness of breath at least 1 of the following: respiratory rate (rr) ≥20 breaths per minute, room air oxygen saturation (spo2) <98%, requirement for supplemental oxygen, heart rate (hr) ≥90 beats per minute, or temperature >38.3°c women of childbearing potential must agree to abstinent or use at least 1 form of contraception not including hormonal contraception from the day of screening through day 30 key

key inclusion criteria: provide written informed consent prior to performing study procedures hospitalized. male or female ≥18 years of age positive for severe acute respiratory syndrome coronavirus 2 presence of symptoms of lower respiratory tract infection (lrti) including at least 1 of the following: fever, cough, sore throat, malaise, headache, muscle pain, or more significant lower respiratory tract symptoms, including shortness of breath at least 1 of the following: respiratory rate (rr) ≥20 breaths per minute, room air oxygen saturation (spo2) <98%, requirement for supplemental oxygen, heart rate (hr) ≥90 beats per minute, or temperature >38.3°c women of childbearing potential must agree to abstinent or use at least 1 form of contraception not including hormonal contraception from the day of screening through day 30 key

key inclusion criteria: 1. provide written informed consent prior to performing study procedures 2. hospitalized. 3. male or female ≥18 years of age 4. positive for severe acute respiratory syndrome coronavirus 2 5. presence of symptoms of lower respiratory tract infection (lrti) including at least 1 of the following: fever, cough, sore throat, malaise, headache, muscle pain, or more significant lower respiratory tract symptoms, including shortness of breath 6. at least 1 of the following: respiratory rate (rr) ≥20 breaths per minute, room air oxygen saturation (spo2) <98%, requirement for supplemental oxygen, heart rate (hr) ≥90 beats per minute, or temperature >38.3°c 7. women of childbearing potential must agree to abstinent or use at least 1 form of contraception not including hormonal contraception from the day of screening through day 30 key

key inclusion criteria: 1. provide written informed consent prior to performing study procedures 2. hospitalized. 3. male or female ≥18 years of age 4. positive for severe acute respiratory syndrome coronavirus 2 5. presence of symptoms of lower respiratory tract infection (lrti) including at least 1 of the following: fever, cough, sore throat, malaise, headache, muscle pain, or more significant lower respiratory tract symptoms, including shortness of breath 6. at least 1 of the following: respiratory rate (rr) ≥20 breaths per minute, room air oxygen saturation (spo2) <98%, requirement for supplemental oxygen, heart rate (hr) ≥90 beats per minute, or temperature >38.3°c 7. women of childbearing potential must agree to abstinent or use at least 1 form of contraception not including hormonal contraception from the day of screening through day 30 key

key inclusion criteria: 1. provide written informed consent prior to performing study procedures 2. hospitalized. 3. male or female ≥18 years of age 4. positive for severe acute respiratory syndrome coronavirus 2 5. presence of symptoms of lower respiratory tract infection (lrti) including at least 1 of the following: fever, cough, sore throat, malaise, headache, muscle pain, or more significant lower respiratory tract symptoms, including shortness of breath 6. at least 1 of the following: respiratory rate (rr) ≥20 breaths per minute, heart rate (hr) ≥90 beats per minute, or temperature >38.3°c 7. room air oxygen saturation (spo2) >93% and <98%, or room air oxygen saturation (spo2) ≤93% with an increase to >93% on nasal cannula oxygen at ≤2 l/min. 8. women of childbearing potential must agree to abstinent or use at least 1 form of contraception not including hormonal contraception from the day of screening through day 30 key

key inclusion criteria: 1. provide written informed consent prior to performing study procedures 2. hospitalized. 3. male or female ≥18 years of age 4. positive for severe acute respiratory syndrome coronavirus 2 5. presence of symptoms of lower respiratory tract infection (lrti) including at least 1 of the following: fever, cough, sore throat, malaise, headache, muscle pain, or more significant lower respiratory tract symptoms, including shortness of breath 6. at least 1 of the following: respiratory rate (rr) ≥20 breaths per minute, heart rate (hr) ≥90 beats per minute, or temperature >38.3°c 7. room air oxygen saturation (spo2) >93% and <98%, or room air oxygen saturation (spo2) ≤93% with an increase to >93% on nasal cannula oxygen at ≤2 l/min. 8. women of childbearing potential must agree to abstinent or use at least 1 form of contraception not including hormonal contraception from the day of screening through day 30 key