inclusion criteria: 1. age ≥18 years at time of signing informed consent form 2. hospitalized with diagnosed covid-19 confirmed by rt-pcr test ≤ 7 days before randomization with any one following criteria * respiratory distress (≥30 breaths/min); * finger oxygen saturation ≤93% at rest; * arterial partial pressure of oxygen (pao2)/fraction of inspired oxygen (fio2) ≤300mmhg 3. willingness of study participant to accept randomization to any assigned treatment arm 4. must agree not to enroll in another study of an investigational agent prior to completion of day 28 of study

inclusion criteria: 1. age ≥18 years at time of signing informed consent form 2. hospitalized with diagnosed covid-19 confirmed by rt-pcr test ≤ 7 days before randomization with any one following criteria * respiratory distress (≥30 breaths/min); * finger oxygen saturation ≤93% at rest; * arterial partial pressure of oxygen (pao2)/fraction of inspired oxygen (fio2) ≤300mmhg 3. willingness of study participant to accept randomization to any assigned treatment arm 4. must agree not to enroll in another study of an investigational agent prior to completion of day 28 of study

inclusion criteria: age ≥18 years at time of signing informed consent form hospitalized with diagnosed covid-19 confirmed by rt-pcr test ≤ 7 days before randomization with any one following criteria respiratory distress (≥30 breaths/min); finger oxygen saturation ≤93% at rest; arterial partial pressure of oxygen (pao2)/fraction of inspired oxygen (fio2) ≤300mmhg willingness of study participant to accept randomization to any assigned treatment arm must agree not to enroll in another study of an investigational agent prior to completion of day 28 of study

inclusion criteria: age ≥18 years at time of signing informed consent form hospitalized with diagnosed covid-19 confirmed by rt-pcr test ≤ 7 days before randomization with any one following criteria respiratory distress (≥30 breaths/min); finger oxygen saturation ≤93% at rest; arterial partial pressure of oxygen (pao2)/fraction of inspired oxygen (fio2) ≤300mmhg willingness of study participant to accept randomization to any assigned treatment arm must agree not to enroll in another study of an investigational agent prior to completion of day 28 of study

inclusion criteria: 1. age ≥18 years at time of signing informed consent form 2. hospitalized with diagnosed covid-19 confirmed by rt-pcr test ≤ 7 days before randomization with any one following criteria - respiratory distress (≥30 breaths/min); - finger oxygen saturation ≤93% at rest; - arterial partial pressure of oxygen (pao2)/fraction of inspired oxygen (fio2) ≤300mmhg 3. willingness of study participant to accept randomization to any assigned treatment arm 4. must agree not to enroll in another study of an investigational agent prior to completion of day 28 of study

inclusion criteria: 1. age ≥18 years at time of signing informed consent form 2. hospitalized with diagnosed covid-19 confirmed by rt-pcr test ≤ 7 days before randomization with any one following criteria - respiratory distress (≥30 breaths/min); - finger oxygen saturation ≤93% at rest; - arterial partial pressure of oxygen (pao2)/fraction of inspired oxygen (fio2) ≤300mmhg 3. willingness of study participant to accept randomization to any assigned treatment arm 4. must agree not to enroll in another study of an investigational agent prior to completion of day 28 of study