* severe heart failure (ejection fraction \< 30%) * severe renal insufficiency (egfr \< 30 ml/min/1.73m2) * severe hemodynamic instability (noradrenalin dose \> 0.3 μg/kg/min) * prior enrollment in the trial * pregnancy * allergy to senicapoc * inability to take enteral medication * more than 24 hours since icu admission * limitations of care * anticipated death within 24 hours

* severe heart failure (ejection fraction \< 30%) * severe renal insufficiency (egfr \< 30 ml/min/1.73m2) * severe hemodynamic instability (noradrenalin dose \> 0.3 μg/kg/min) * prior enrollment in the trial * pregnancy * allergy to senicapoc * inability to take enteral medication * more than 24 hours since icu admission * limitations of care * anticipated death within 24 hours

- severe heart failure (ejection fraction < 30%) - severe renal insufficiency (egfr < 30 ml/min/1.73m2) - severe hemodynamic instability (noradrenalin dose > 0.3 μg/kg/min) - prior enrollment in the trial - pregnancy - allergy to senicapoc - inability to take enteral medication - more than 24 hours since icu admission - limitations of care - anticipated death within 24 hours

- severe heart failure (ejection fraction < 30%) - severe renal insufficiency (egfr < 30 ml/min/1.73m2) - severe hemodynamic instability (noradrenalin dose > 0.3 μg/kg/min) - prior enrollment in the trial - pregnancy - allergy to senicapoc - inability to take enteral medication - more than 24 hours since icu admission - limitations of care - anticipated death within 24 hours