1. clear evidence of an acute coronary syndrome or myo-pericarditis that requires specific treatment that precludes randomization. 2. evidence of active bleeding 3. pregnancy. 4. age \<18 years

1. clear evidence of an acute coronary syndrome or myo-pericarditis that requires specific treatment that precludes randomization. 2. evidence of active bleeding 3. pregnancy. 4. age \<18 years

clear evidence of an acute coronary syndrome or myo-pericarditis that requires specific treatment that precludes randomization. evidence of active bleeding pregnancy. age <18 years

clear evidence of an acute coronary syndrome or myo-pericarditis that requires specific treatment that precludes randomization. evidence of active bleeding pregnancy. age <18 years

clear evidence of cardiac pathology needing acs treatment. myocarditis with serum troponin > 5000 bleeding risk suspected e.g. recent surgery, history of gi bleed, other abnormal blood results (hb<10g/dl, plts <100, any evidence of dic) study treatment may negatively impact standard best care (physician discretion). unrelated co-morbidity with life expectancy <3 months. pregnancy. age <18 years and >85 years.

clear evidence of cardiac pathology needing acs treatment. myocarditis with serum troponin > 5000 bleeding risk suspected e.g. recent surgery, history of gi bleed, other abnormal blood results (hb<10g/dl, plts <100, any evidence of dic) study treatment may negatively impact standard best care (physician discretion). unrelated co-morbidity with life expectancy <3 months. pregnancy. age <18 years and >85 years.

1. clear evidence of cardiac pathology needing acs treatment. 2. myocarditis with serum troponin > 5000 3. bleeding risk suspected e.g. recent surgery, history of gi bleed, other abnormal blood results (hb<10g/dl, plts <100, any evidence of dic) 4. study treatment may negatively impact standard best care (physician discretion). 5. unrelated co-morbidity with life expectancy <3 months. 6. pregnancy. 7. age <18 years and >85 years.

1. clear evidence of cardiac pathology needing acs treatment. 2. myocarditis with serum troponin > 5000 3. bleeding risk suspected e.g. recent surgery, history of gi bleed, other abnormal blood results (hb<10g/dl, plts <100, any evidence of dic) 4. study treatment may negatively impact standard best care (physician discretion). 5. unrelated co-morbidity with life expectancy <3 months. 6. pregnancy. 7. age <18 years and >85 years.