1. allergy to any component of the investigational vaccine, or a more severe allergic reaction and history of allergies in the past. 2. pregnant and nursing women. a negative serum or urine pregnancy test during screening and on the day of and prior to each dose must be documented before the vaccine is administered to a female subject of childbearing potential. 3. live in a nursing home or long-term care facility. 4. chronic lung disease including chronic obstructive pulmonary disease (copd) or moderate to severe asthma. 5. pulmonary fibrosis. 6. active smoker. 7. bone marrow or organ transplantation. 8. obesity (defined as body mass index \[bmi\] of 30 kg/m2 or higher). 9. diabetes. 10. chronic kidney disease. 11. liver disease. 12. sickle cell disease. 13. thalassemia. 14. doctors, nurses, first responders, and other healthcare workers working in direct contact with covid-19 patients. 15. any disease associated with acute fever, or any infection. 16. self-reported history of severe acute respiratory syndrome (sars). 17. history of hepatitis b or hepatitis c. 18. hiv or other acquired or hereditary immunodeficiency. 19. serious cardiovascular diseases, such as heart failure, coronary artery disease, cardiomyopathies, arrhythmia, conduction block, myocardial infarction, pulmonary hypertension, severe hypertension without controllable drugs, etc. 20. cerebrovascular disease. 21. cystic fibrosis. 22. neurologic conditions, such as dementia. 23. hereditary or acquired angioneurotic edema. 24. urticaria in the last 12 months. 25. no spleen or functional asplenia. 26. platelet disorder or other bleeding disorder that may cause injection contraindication. 27. chronic use (more than 14 continuous days) of any medications that may be associated with impaired immune responsiveness within 3 months before administration of study vaccine. (including, but not limited to, systemic corticosteroids exceeding 10 mg/day of prednisone equivalent, allergy injections, immunoglobulin, interferon, immunomodulators. the use of low dose topical, ophthalmic, inhaled and intranasal steroid preparations will be permitted.) 28. prior administration of blood products in last 4 months. 29. prior administration of other research medicines in last 1 month. 30. received or plans to receive an attenuated vaccine within 1 month before or after each study vaccination. 31. received or plans to receive an inactivated vaccine within 14 days before or after each study vaccination. 32. current treatment with investigational agents for prophylaxis of covid-19. 33. have a household contact that has been diagnosed with covid-19. 34. current anti-tuberculosis prophylaxis or therapy. 35. currently receiving treatment for cancer or history of cancer in the last five years (except basal cell carcinoma of the skin and cervical carcinoma in situ). 36. according to the judgement of investigator, various medical, psychological, social or other conditions that could affect the subjects ability to sign informed consent. 37. assessed by the investigator to be unable or unwilling to comply with the requirements of the protocol.

1. allergy to any component of the investigational vaccine, or a more severe allergic reaction and history of allergies in the past. 2. pregnant and nursing women. a negative serum or urine pregnancy test during screening and on the day of and prior to each dose must be documented before the vaccine is administered to a female subject of childbearing potential. 3. live in a nursing home or long-term care facility. 4. chronic lung disease including chronic obstructive pulmonary disease (copd) or moderate to severe asthma. 5. pulmonary fibrosis. 6. active smoker. 7. bone marrow or organ transplantation. 8. obesity (defined as body mass index \[bmi\] of 30 kg/m2 or higher). 9. diabetes. 10. chronic kidney disease. 11. liver disease. 12. sickle cell disease. 13. thalassemia. 14. doctors, nurses, first responders, and other healthcare workers working in direct contact with covid-19 patients. 15. any disease associated with acute fever, or any infection. 16. self-reported history of severe acute respiratory syndrome (sars). 17. history of hepatitis b or hepatitis c. 18. hiv or other acquired or hereditary immunodeficiency. 19. serious cardiovascular diseases, such as heart failure, coronary artery disease, cardiomyopathies, arrhythmia, conduction block, myocardial infarction, pulmonary hypertension, severe hypertension without controllable drugs, etc. 20. cerebrovascular disease. 21. cystic fibrosis. 22. neurologic conditions, such as dementia. 23. hereditary or acquired angioneurotic edema. 24. urticaria in the last 12 months. 25. no spleen or functional asplenia. 26. platelet disorder or other bleeding disorder that may cause injection contraindication. 27. chronic use (more than 14 continuous days) of any medications that may be associated with impaired immune responsiveness within 3 months before administration of study vaccine. (including, but not limited to, systemic corticosteroids exceeding 10 mg/day of prednisone equivalent, allergy injections, immunoglobulin, interferon, immunomodulators. the use of low dose topical, ophthalmic, inhaled and intranasal steroid preparations will be permitted.) 28. prior administration of blood products in last 4 months. 29. prior administration of other research medicines in last 1 month. 30. received or plans to receive an attenuated vaccine within 1 month before or after each study vaccination. 31. received or plans to receive an inactivated vaccine within 14 days before or after each study vaccination. 32. current treatment with investigational agents for prophylaxis of covid-19. 33. have a household contact that has been diagnosed with covid-19. 34. current anti-tuberculosis prophylaxis or therapy. 35. currently receiving treatment for cancer or history of cancer in the last five years (except basal cell carcinoma of the skin and cervical carcinoma in situ). 36. according to the judgement of investigator, various medical, psychological, social or other conditions that could affect the subjects ability to sign informed consent. 37. assessed by the investigator to be unable or unwilling to comply with the requirements of the protocol.

allergy to any component of the investigational vaccine, or a more severe allergic reaction and history of allergies in the past. pregnant and nursing women. a negative serum or urine pregnancy test during screening and on the day of and prior to each dose must be documented before the vaccine is administered to a female subject of childbearing potential. live in a nursing home or long-term care facility. chronic lung disease including chronic obstructive pulmonary disease (copd) or moderate to severe asthma. pulmonary fibrosis. active smoker. bone marrow or organ transplantation. obesity (defined as body mass index [bmi] of 30 kg/m2 or higher). diabetes. chronic kidney disease. liver disease. sickle cell disease. thalassemia. doctors, nurses, first responders, and other healthcare workers working in direct contact with covid-19 patients. any disease associated with acute fever, or any infection. self-reported history of severe acute respiratory syndrome (sars). history of hepatitis b or hepatitis c. hiv or other acquired or hereditary immunodeficiency. serious cardiovascular diseases, such as heart failure, coronary artery disease, cardiomyopathies, arrhythmia, conduction block, myocardial infarction, pulmonary hypertension, severe hypertension without controllable drugs, etc. cerebrovascular disease. cystic fibrosis. neurologic conditions, such as dementia. hereditary or acquired angioneurotic edema. urticaria in the last 12 months. no spleen or functional asplenia. platelet disorder or other bleeding disorder that may cause injection contraindication. chronic use (more than 14 continuous days) of any medications that may be associated with impaired immune responsiveness within 3 months before administration of study vaccine. (including, but not limited to, systemic corticosteroids exceeding 10 mg/day of prednisone equivalent, allergy injections, immunoglobulin, interferon, immunomodulators. the use of low dose topical, ophthalmic, inhaled and intranasal steroid preparations will be permitted.) prior administration of blood products in last 4 months. prior administration of other research medicines in last 1 month. received or plans to receive an attenuated vaccine within 1 month before or after each study vaccination. received or plans to receive an inactivated vaccine within 14 days before or after each study vaccination. current treatment with investigational agents for prophylaxis of covid-19. have a household contact that has been diagnosed with covid-19. current anti-tuberculosis prophylaxis or therapy. currently receiving treatment for cancer or history of cancer in the last five years (except basal cell carcinoma of the skin and cervical carcinoma in situ). according to the judgement of investigator, various medical, psychological, social or other conditions that could affect the subjects ability to sign informed consent. assessed by the investigator to be unable or unwilling to comply with the requirements of the protocol.

allergy to any component of the investigational vaccine, or a more severe allergic reaction and history of allergies in the past. pregnant and nursing women. a negative serum or urine pregnancy test during screening and on the day of and prior to each dose must be documented before the vaccine is administered to a female subject of childbearing potential. live in a nursing home or long-term care facility. chronic lung disease including chronic obstructive pulmonary disease (copd) or moderate to severe asthma. pulmonary fibrosis. active smoker. bone marrow or organ transplantation. obesity (defined as body mass index [bmi] of 30 kg/m2 or higher). diabetes. chronic kidney disease. liver disease. sickle cell disease. thalassemia. doctors, nurses, first responders, and other healthcare workers working in direct contact with covid-19 patients. any disease associated with acute fever, or any infection. self-reported history of severe acute respiratory syndrome (sars). history of hepatitis b or hepatitis c. hiv or other acquired or hereditary immunodeficiency. serious cardiovascular diseases, such as heart failure, coronary artery disease, cardiomyopathies, arrhythmia, conduction block, myocardial infarction, pulmonary hypertension, severe hypertension without controllable drugs, etc. cerebrovascular disease. cystic fibrosis. neurologic conditions, such as dementia. hereditary or acquired angioneurotic edema. urticaria in the last 12 months. no spleen or functional asplenia. platelet disorder or other bleeding disorder that may cause injection contraindication. chronic use (more than 14 continuous days) of any medications that may be associated with impaired immune responsiveness within 3 months before administration of study vaccine. (including, but not limited to, systemic corticosteroids exceeding 10 mg/day of prednisone equivalent, allergy injections, immunoglobulin, interferon, immunomodulators. the use of low dose topical, ophthalmic, inhaled and intranasal steroid preparations will be permitted.) prior administration of blood products in last 4 months. prior administration of other research medicines in last 1 month. received or plans to receive an attenuated vaccine within 1 month before or after each study vaccination. received or plans to receive an inactivated vaccine within 14 days before or after each study vaccination. current treatment with investigational agents for prophylaxis of covid-19. have a household contact that has been diagnosed with covid-19. current anti-tuberculosis prophylaxis or therapy. currently receiving treatment for cancer or history of cancer in the last five years (except basal cell carcinoma of the skin and cervical carcinoma in situ). according to the judgement of investigator, various medical, psychological, social or other conditions that could affect the subjects ability to sign informed consent. assessed by the investigator to be unable or unwilling to comply with the requirements of the protocol.

1. allergy to any component of the investigational vaccine, or a more severe allergic reaction and history of allergies in the past. 2. pregnant and nursing women. a negative serum or urine pregnancy test during screening and on the day of and prior to each dose must be documented before the vaccine is administered to a female subject of childbearing potential. 3. live in a nursing home or long-term care facility. 4. chronic lung disease including chronic obstructive pulmonary disease (copd) or moderate to severe asthma. 5. pulmonary fibrosis. 6. active smoker. 7. bone marrow or organ transplantation. 8. obesity (defined as body mass index [bmi] of 30 kg/m2 or higher). 9. diabetes. 10. chronic kidney disease. 11. liver disease. 12. sickle cell disease. 13. thalassemia. 14. doctors, nurses, first responders, and other healthcare workers working in direct contact with covid-19 patients. 15. any disease associated with acute fever, or any infection. 16. self-reported history of severe acute respiratory syndrome (sars). 17. history of hepatitis b or hepatitis c. 18. hiv or other acquired or hereditary immunodeficiency. 19. serious cardiovascular diseases, such as heart failure, coronary artery disease, cardiomyopathies, arrhythmia, conduction block, myocardial infarction, pulmonary hypertension, severe hypertension without controllable drugs, etc. 20. cerebrovascular disease. 21. cystic fibrosis. 22. neurologic conditions, such as dementia. 23. hereditary or acquired angioneurotic edema. 24. urticaria in the last 12 months. 25. no spleen or functional asplenia. 26. platelet disorder or other bleeding disorder that may cause injection contraindication. 27. chronic use (more than 14 continuous days) of any medications that may be associated with impaired immune responsiveness within 3 months before administration of study vaccine. (including, but not limited to, systemic corticosteroids exceeding 10 mg/day of prednisone equivalent, allergy injections, immunoglobulin, interferon, immunomodulators. the use of low dose topical, ophthalmic, inhaled and intranasal steroid preparations will be permitted.) 28. prior administration of blood products in last 4 months. 29. prior administration of other research medicines in last 1 month. 30. received or plans to receive an attenuated vaccine within 1 month before or after each study vaccination. 31. received or plans to receive an inactivated vaccine within 14 days before or after each study vaccination. 32. current treatment with investigational agents for prophylaxis of covid-19. 33. have a household contact that has been diagnosed with covid-19. 34. current anti-tuberculosis prophylaxis or therapy. 35. currently receiving treatment for cancer or history of cancer in the last five years (except basal cell carcinoma of the skin and cervical carcinoma in situ). 36. according to the judgement of investigator, various medical, psychological, social or other conditions that could affect the subjects ability to sign informed consent. 37. assessed by the investigator to be unable or unwilling to comply with the requirements of the protocol.

1. allergy to any component of the investigational vaccine, or a more severe allergic reaction and history of allergies in the past. 2. pregnant and nursing women. a negative serum or urine pregnancy test during screening and on the day of and prior to each dose must be documented before the vaccine is administered to a female subject of childbearing potential. 3. live in a nursing home or long-term care facility. 4. chronic lung disease including chronic obstructive pulmonary disease (copd) or moderate to severe asthma. 5. pulmonary fibrosis. 6. active smoker. 7. bone marrow or organ transplantation. 8. obesity (defined as body mass index [bmi] of 30 kg/m2 or higher). 9. diabetes. 10. chronic kidney disease. 11. liver disease. 12. sickle cell disease. 13. thalassemia. 14. doctors, nurses, first responders, and other healthcare workers working in direct contact with covid-19 patients. 15. any disease associated with acute fever, or any infection. 16. self-reported history of severe acute respiratory syndrome (sars). 17. history of hepatitis b or hepatitis c. 18. hiv or other acquired or hereditary immunodeficiency. 19. serious cardiovascular diseases, such as heart failure, coronary artery disease, cardiomyopathies, arrhythmia, conduction block, myocardial infarction, pulmonary hypertension, severe hypertension without controllable drugs, etc. 20. cerebrovascular disease. 21. cystic fibrosis. 22. neurologic conditions, such as dementia. 23. hereditary or acquired angioneurotic edema. 24. urticaria in the last 12 months. 25. no spleen or functional asplenia. 26. platelet disorder or other bleeding disorder that may cause injection contraindication. 27. chronic use (more than 14 continuous days) of any medications that may be associated with impaired immune responsiveness within 3 months before administration of study vaccine. (including, but not limited to, systemic corticosteroids exceeding 10 mg/day of prednisone equivalent, allergy injections, immunoglobulin, interferon, immunomodulators. the use of low dose topical, ophthalmic, inhaled and intranasal steroid preparations will be permitted.) 28. prior administration of blood products in last 4 months. 29. prior administration of other research medicines in last 1 month. 30. received or plans to receive an attenuated vaccine within 1 month before or after each study vaccination. 31. received or plans to receive an inactivated vaccine within 14 days before or after each study vaccination. 32. current treatment with investigational agents for prophylaxis of covid-19. 33. have a household contact that has been diagnosed with covid-19. 34. current anti-tuberculosis prophylaxis or therapy. 35. currently receiving treatment for cancer or history of cancer in the last five years (except basal cell carcinoma of the skin and cervical carcinoma in situ). 36. according to the judgement of investigator, various medical, psychological, social or other conditions that could affect the subjects ability to sign informed consent. 37. assessed by the investigator to be unable or unwilling to comply with the requirements of the protocol.

allergy to any component of the investigational vaccine, or a more severe allergic reaction and history of allergies in the past. pregnant and nursing women. a negative serum or urine pregnancy test during screening and on the day of and prior to each dose must be documented before the vaccine is administered to a female subject of childbearing potential. live in a nursing home or long-term care facility. chronic lung disease including chronic obstructive pulmonary disease (copd) or moderate to severe asthma. pulmonary fibrosis. active smoker. bone marrow or organ transplantation. obesity (defined as body mass index [bmi] of 30 kg/m2 or higher). diabetes. chronic kidney disease. liver disease. sickle cell disease. thalassemia. doctors, nurses, first responders, and other healthcare workers working in direct contact with covid-19 patients. any disease associated with acute fever, or any infection. self-reported history of severe acute respiratory syndrome (sars). history of hepatitis b or hepatitis c. hiv or other acquired or hereditary immunodeficiency. serious cardiovascular diseases, such as heart failure, coronary artery disease, cardiomyopathies, arrhythmia, conduction block, myocardial infarction, pulmonary hypertension, severe hypertension without controllable drugs, etc. cerebrovascular disease. cystic fibrosis. neurologic conditions, such as dementia. hereditary or acquired angioneurotic edema. urticaria in the last 12 months. no spleen or functional asplenia. platelet disorder or other bleeding disorder that may cause injection contraindication. chronic use (more than 14 continuous days) of any medications that may be associated with impaired immune responsiveness within 3 months before administration of study vaccine. (including, but not limited to, systemic corticosteroids exceeding 10 mg/day of prednisone equivalent, allergy injections, immunoglobulin, interferon, immunomodulators. the use of low dose topical, ophthalmic, inhaled and intranasal steroid preparations will be permitted.) prior administration of blood products in last 4 months. prior administration of other research medicines in last 1 month. received or plans to receive an attenuated vaccine within 1 month before or after each study vaccination. received or plans to receive an inactivated vaccine within 14 days before or after each study vaccination. current treatment with investigational agents for prophylaxis of covid-19. have a household contact that has been diagnosed with covid-19. current anti-tuberculosis prophylaxis or therapy. currently receiving treatment for cancer or history of cancer in the last five years (except basal cell carcinoma of the skin and cervical carcinoma in situ). according to the judgement of investigator, various medical, psychological, social or other conditions that could affect the subjects ability to sign informed consent. assessed by the investigator to be unable or unwilling to comply with the requirements of the protocol.

allergy to any component of the investigational vaccine, or a more severe allergic reaction and history of allergies in the past. pregnant and nursing women. a negative serum or urine pregnancy test during screening and on the day of and prior to each dose must be documented before the vaccine is administered to a female subject of childbearing potential. live in a nursing home or long-term care facility. chronic lung disease including chronic obstructive pulmonary disease (copd) or moderate to severe asthma. pulmonary fibrosis. active smoker. bone marrow or organ transplantation. obesity (defined as body mass index [bmi] of 30 kg/m2 or higher). diabetes. chronic kidney disease. liver disease. sickle cell disease. thalassemia. doctors, nurses, first responders, and other healthcare workers working in direct contact with covid-19 patients. any disease associated with acute fever, or any infection. self-reported history of severe acute respiratory syndrome (sars). history of hepatitis b or hepatitis c. hiv or other acquired or hereditary immunodeficiency. serious cardiovascular diseases, such as heart failure, coronary artery disease, cardiomyopathies, arrhythmia, conduction block, myocardial infarction, pulmonary hypertension, severe hypertension without controllable drugs, etc. cerebrovascular disease. cystic fibrosis. neurologic conditions, such as dementia. hereditary or acquired angioneurotic edema. urticaria in the last 12 months. no spleen or functional asplenia. platelet disorder or other bleeding disorder that may cause injection contraindication. chronic use (more than 14 continuous days) of any medications that may be associated with impaired immune responsiveness within 3 months before administration of study vaccine. (including, but not limited to, systemic corticosteroids exceeding 10 mg/day of prednisone equivalent, allergy injections, immunoglobulin, interferon, immunomodulators. the use of low dose topical, ophthalmic, inhaled and intranasal steroid preparations will be permitted.) prior administration of blood products in last 4 months. prior administration of other research medicines in last 1 month. received or plans to receive an attenuated vaccine within 1 month before or after each study vaccination. received or plans to receive an inactivated vaccine within 14 days before or after each study vaccination. current treatment with investigational agents for prophylaxis of covid-19. have a household contact that has been diagnosed with covid-19. current anti-tuberculosis prophylaxis or therapy. currently receiving treatment for cancer or history of cancer in the last five years (except basal cell carcinoma of the skin and cervical carcinoma in situ). according to the judgement of investigator, various medical, psychological, social or other conditions that could affect the subjects ability to sign informed consent. assessed by the investigator to be unable or unwilling to comply with the requirements of the protocol.

1. allergy to any component of the investigational vaccine, or a more severe allergic reaction and history of allergies in the past. 2. pregnant and nursing women. a negative serum or urine pregnancy test during screening and on the day of and prior to each dose must be documented before the vaccine is administered to a female subject of childbearing potential. 3. live in a nursing home or long-term care facility. 4. chronic lung disease including chronic obstructive pulmonary disease (copd) or moderate to severe asthma. 5. pulmonary fibrosis. 6. active smoker. 7. bone marrow or organ transplantation. 8. obesity (defined as body mass index [bmi] of 30 kg/m2 or higher). 9. diabetes. 10. chronic kidney disease. 11. liver disease. 12. sickle cell disease. 13. thalassemia. 14. doctors, nurses, first responders, and other healthcare workers working in direct contact with covid-19 patients. 15. any disease associated with acute fever, or any infection. 16. self-reported history of severe acute respiratory syndrome (sars). 17. history of hepatitis b or hepatitis c. 18. hiv or other acquired or hereditary immunodeficiency. 19. serious cardiovascular diseases, such as heart failure, coronary artery disease, cardiomyopathies, arrhythmia, conduction block, myocardial infarction, pulmonary hypertension, severe hypertension without controllable drugs, etc. 20. cerebrovascular disease. 21. cystic fibrosis. 22. neurologic conditions, such as dementia. 23. hereditary or acquired angioneurotic edema. 24. urticaria in the last 12 months. 25. no spleen or functional asplenia. 26. platelet disorder or other bleeding disorder that may cause injection contraindication. 27. chronic use (more than 14 continuous days) of any medications that may be associated with impaired immune responsiveness within 3 months before administration of study vaccine. (including, but not limited to, systemic corticosteroids exceeding 10 mg/day of prednisone equivalent, allergy injections, immunoglobulin, interferon, immunomodulators. the use of low dose topical, ophthalmic, inhaled and intranasal steroid preparations will be permitted.) 28. prior administration of blood products in last 4 months. 29. prior administration of other research medicines in last 1 month. 30. received or plans to receive an attenuated vaccine within 1 month before or after each study vaccination. 31. received or plans to receive an inactivated vaccine within 14 days before or after each study vaccination. 32. current treatment with investigational agents for prophylaxis of covid-19. 33. have a household contact that has been diagnosed with covid-19. 34. current anti-tuberculosis prophylaxis or therapy. 35. currently receiving treatment for cancer or history of cancer in the last five years (except basal cell carcinoma of the skin and cervical carcinoma in situ). 36. according to the judgement of investigator, various medical, psychological, social or other conditions that could affect the subjects ability to sign informed consent. 37. assessed by the investigator to be unable or unwilling to comply with the requirements of the protocol.

1. allergy to any component of the investigational vaccine, or a more severe allergic reaction and history of allergies in the past. 2. pregnant and nursing women. a negative serum or urine pregnancy test during screening and on the day of and prior to each dose must be documented before the vaccine is administered to a female subject of childbearing potential. 3. live in a nursing home or long-term care facility. 4. chronic lung disease including chronic obstructive pulmonary disease (copd) or moderate to severe asthma. 5. pulmonary fibrosis. 6. active smoker. 7. bone marrow or organ transplantation. 8. obesity (defined as body mass index [bmi] of 30 kg/m2 or higher). 9. diabetes. 10. chronic kidney disease. 11. liver disease. 12. sickle cell disease. 13. thalassemia. 14. doctors, nurses, first responders, and other healthcare workers working in direct contact with covid-19 patients. 15. any disease associated with acute fever, or any infection. 16. self-reported history of severe acute respiratory syndrome (sars). 17. history of hepatitis b or hepatitis c. 18. hiv or other acquired or hereditary immunodeficiency. 19. serious cardiovascular diseases, such as heart failure, coronary artery disease, cardiomyopathies, arrhythmia, conduction block, myocardial infarction, pulmonary hypertension, severe hypertension without controllable drugs, etc. 20. cerebrovascular disease. 21. cystic fibrosis. 22. neurologic conditions, such as dementia. 23. hereditary or acquired angioneurotic edema. 24. urticaria in the last 12 months. 25. no spleen or functional asplenia. 26. platelet disorder or other bleeding disorder that may cause injection contraindication. 27. chronic use (more than 14 continuous days) of any medications that may be associated with impaired immune responsiveness within 3 months before administration of study vaccine. (including, but not limited to, systemic corticosteroids exceeding 10 mg/day of prednisone equivalent, allergy injections, immunoglobulin, interferon, immunomodulators. the use of low dose topical, ophthalmic, inhaled and intranasal steroid preparations will be permitted.) 28. prior administration of blood products in last 4 months. 29. prior administration of other research medicines in last 1 month. 30. received or plans to receive an attenuated vaccine within 1 month before or after each study vaccination. 31. received or plans to receive an inactivated vaccine within 14 days before or after each study vaccination. 32. current treatment with investigational agents for prophylaxis of covid-19. 33. have a household contact that has been diagnosed with covid-19. 34. current anti-tuberculosis prophylaxis or therapy. 35. currently receiving treatment for cancer or history of cancer in the last five years (except basal cell carcinoma of the skin and cervical carcinoma in situ). 36. according to the judgement of investigator, various medical, psychological, social or other conditions that could affect the subjects ability to sign informed consent. 37. assessed by the investigator to be unable or unwilling to comply with the requirements of the protocol.