None

None

- personal history of seizure disorder, encephalopathy or psychosis; - allergic history to any vaccine, or allergic to any vaccine ingredient; - woman who is pregnant (positive urine pregnancy test) or lactating, or plans to become pregnant during the next 3 months; - any acute febrile disease (oral temperature ≥38.0○c) or active infectious disease on the day of vaccination; - medical history of sars (sars-cov-1); - serious cardiovascular diseases, such as arrhythmia, conduction block, history of myocardial infarction, severe hypertension not controlled with medication; - serious chronic disease such as asthma, diabetes and thyroid disease, etc.; - immunodeficiency, asplenia or functional asplenia; - platelet disorder or other bleeding disorder that may cause intramuscular injection contraindication; - immunosuppressive medication, anti-allergic, cytotoxic therapy, inhaled corticosteroids (excluding corticosteroid spray for allergic rhinitis, surface corticosteroid therapy for acute non-complicated dermatitis) in the last 6 months; - prior administration of blood products in last 4 months; - other vaccination(s) or investigational drugs within 1 month before study onset, or planned use during the study period; - prior administration of any live attenuated vaccine within 1 month before study onset; - prior administration of subunit or inactivated non-sars-cov-2 vaccine within 1 month before study onset; - prior administration of any other vaccine considered (or being considered) to protect against sars-cov-2 any time before study onset or during study period; - prior participation in other studies involving study intervention containing lipid nanoparticles; - any condition that, in the opinion of the investigators, may interfere with the participant's compliance or evaluation of study objectives or informed consent (i.e. medical, psychological, social or other conditions, etc.); - chronic obstructive pulmonary disease (copd), current smoker or vaper. - history of hypertension. - history or diagnosis of coagulopathies. - body mass index (bmi) >30kg/m2. - high risk of acquiring sars-cov-2 infection due to surroundings, contacts or circumstances. explicitly exclude healthcare and "essential workers"/at risk population.

- personal history of seizure disorder, encephalopathy or psychosis; - allergic history to any vaccine, or allergic to any vaccine ingredient; - woman who is pregnant (positive urine pregnancy test) or lactating, or plans to become pregnant during the next 3 months; - any acute febrile disease (oral temperature ≥38.0○c) or active infectious disease on the day of vaccination; - medical history of sars (sars-cov-1); - serious cardiovascular diseases, such as arrhythmia, conduction block, history of myocardial infarction, severe hypertension not controlled with medication; - serious chronic disease such as asthma, diabetes and thyroid disease, etc.; - immunodeficiency, asplenia or functional asplenia; - platelet disorder or other bleeding disorder that may cause intramuscular injection contraindication; - immunosuppressive medication, anti-allergic, cytotoxic therapy, inhaled corticosteroids (excluding corticosteroid spray for allergic rhinitis, surface corticosteroid therapy for acute non-complicated dermatitis) in the last 6 months; - prior administration of blood products in last 4 months; - other vaccination(s) or investigational drugs within 1 month before study onset, or planned use during the study period; - prior administration of any live attenuated vaccine within 1 month before study onset; - prior administration of subunit or inactivated non-sars-cov-2 vaccine within 1 month before study onset; - prior administration of any other vaccine considered (or being considered) to protect against sars-cov-2 any time before study onset or during study period; - prior participation in other studies involving study intervention containing lipid nanoparticles; - any condition that, in the opinion of the investigators, may interfere with the participant's compliance or evaluation of study objectives or informed consent (i.e. medical, psychological, social or other conditions, etc.); - chronic obstructive pulmonary disease (copd), current smoker or vaper. - history of hypertension. - history or diagnosis of coagulopathies. - body mass index (bmi) >30kg/m2. - high risk of acquiring sars-cov-2 infection due to surroundings, contacts or circumstances. explicitly exclude healthcare and "essential workers"/at risk population.