1. any subject who self-reports: 1. as a current smoker, or stopped smoking within the past 6 months. 2. as a previous smoker with a ≥10 pack year smoking history. 3. has a household member who currently smokes in the house. 2. subjects with a medical history of chronic obstructive pulmonary disease (copd), emphysema or chronic bronchitis requiring active treatment with a prescription medication 3. the subject has already had symptoms consistent with covid-19 at screening. 4. subjects who require chronic supplemental oxygen therapy at screening. 5. subjects with current evidence of an unstable medical disorder including an unstable respiratory disorder, gastrointestinal disorder (including child-pugh class b and c hepatic impairment), renal disorder or hematologic disorder (including active leukemia) for which they have had an exacerbation of symptoms within the past month, or are undergoing a change in treatment. 6. the following cardiac conditions: 1. unstable angina pectoris 2. history of myocardial infarction (mi), coronary bypass surgery, or any percutaneous coronary intervention (pci) within 6 months prior to screening 3. congestive heart failure requiring active treatment with a prescription medication 4. unstable or life-threatening cardiac arrhythmia a. chronic stable atrial fibrillation is allowed 7. subjects with a history of systemic autoimmune diseases (e.g., lupus, inflammatory bowel disease, rheumatoid arthritis, etc.). a. psoriasis confined to the skin and eczema are allowed 8. subjects receiving immunosuppressive therapy including chronic use of supraphysiologic steroids such as prednisone \>10 mg daily (however, inhaled corticosteroids and acute use of higher doses of prednisone to treat conditions such as exacerbation of asthma or other acute conditions are allowed). 9. subjects with an immunodeficiency disease, including a history of a positive human immunodeficiency virus (hiv) test result. 10. subjects with a history of gastric bypass surgery. 11. subjects who require treatment with strong cyp3a4 or cyp1a2 inhibitors or inducers, or subjects who require treatment with digoxin. 12. use of any other investigational medication or participation in any other investigational study within 5 half-lives of the investigational medication, or within 30 days, whichever is longer; or longer if required by local regulations.

1. any subject who self-reports: 1. as a current smoker, or stopped smoking within the past 6 months. 2. as a previous smoker with a ≥10 pack year smoking history. 3. has a household member who currently smokes in the house. 2. subjects with a medical history of chronic obstructive pulmonary disease (copd), emphysema or chronic bronchitis requiring active treatment with a prescription medication 3. the subject has already had symptoms consistent with covid-19 at screening. 4. subjects who require chronic supplemental oxygen therapy at screening. 5. subjects with current evidence of an unstable medical disorder including an unstable respiratory disorder, gastrointestinal disorder (including child-pugh class b and c hepatic impairment), renal disorder or hematologic disorder (including active leukemia) for which they have had an exacerbation of symptoms within the past month, or are undergoing a change in treatment. 6. the following cardiac conditions: 1. unstable angina pectoris 2. history of myocardial infarction (mi), coronary bypass surgery, or any percutaneous coronary intervention (pci) within 6 months prior to screening 3. congestive heart failure requiring active treatment with a prescription medication 4. unstable or life-threatening cardiac arrhythmia a. chronic stable atrial fibrillation is allowed 7. subjects with a history of systemic autoimmune diseases (e.g., lupus, inflammatory bowel disease, rheumatoid arthritis, etc.). a. psoriasis confined to the skin and eczema are allowed 8. subjects receiving immunosuppressive therapy including chronic use of supraphysiologic steroids such as prednisone \>10 mg daily (however, inhaled corticosteroids and acute use of higher doses of prednisone to treat conditions such as exacerbation of asthma or other acute conditions are allowed). 9. subjects with an immunodeficiency disease, including a history of a positive human immunodeficiency virus (hiv) test result. 10. subjects with a history of gastric bypass surgery. 11. subjects who require treatment with strong cyp3a4 or cyp1a2 inhibitors or inducers, or subjects who require treatment with digoxin. 12. use of any other investigational medication or participation in any other investigational study within 5 half-lives of the investigational medication, or within 30 days, whichever is longer; or longer if required by local regulations.

any subject who self-reports: as a current smoker, or stopped smoking within the past 6 months. as a previous smoker with a ≥10 pack year smoking history. has a household member who currently smokes in the house. subjects with a medical history of chronic obstructive pulmonary disease (copd), emphysema or chronic bronchitis requiring active treatment with a prescription medication the subject has already had symptoms consistent with covid-19 at screening. subjects who require chronic supplemental oxygen therapy at screening. subjects with current evidence of an unstable medical disorder including an unstable respiratory disorder, gastrointestinal disorder (including child-pugh class b and c hepatic impairment), renal disorder or hematologic disorder (including active leukemia) for which they have had an exacerbation of symptoms within the past month, or are undergoing a change in treatment. the following cardiac conditions: unstable angina pectoris history of myocardial infarction (mi), coronary bypass surgery, or any percutaneous coronary intervention (pci) within 6 months prior to screening congestive heart failure requiring active treatment with a prescription medication unstable or life-threatening cardiac arrhythmia a. chronic stable atrial fibrillation is allowed subjects with a history of systemic autoimmune diseases (e.g., lupus, inflammatory bowel disease, rheumatoid arthritis, etc.). a. psoriasis confined to the skin and eczema are allowed subjects receiving immunosuppressive therapy including chronic use of supraphysiologic steroids such as prednisone >10 mg daily (however, inhaled corticosteroids and acute use of higher doses of prednisone to treat conditions such as exacerbation of asthma or other acute conditions are allowed). subjects with an immunodeficiency disease, including a history of a positive human immunodeficiency virus (hiv) test result. subjects with a history of gastric bypass surgery. subjects who require treatment with strong cyp3a4 or cyp1a2 inhibitors or inducers, or subjects who require treatment with digoxin. use of any other investigational medication or participation in any other investigational study within 5 half-lives of the investigational medication, or within 30 days, whichever is longer; or longer if required by local regulations.

any subject who self-reports: as a current smoker, or stopped smoking within the past 6 months. as a previous smoker with a ≥10 pack year smoking history. has a household member who currently smokes in the house. subjects with a medical history of chronic obstructive pulmonary disease (copd), emphysema or chronic bronchitis requiring active treatment with a prescription medication the subject has already had symptoms consistent with covid-19 at screening. subjects who require chronic supplemental oxygen therapy at screening. subjects with current evidence of an unstable medical disorder including an unstable respiratory disorder, gastrointestinal disorder (including child-pugh class b and c hepatic impairment), renal disorder or hematologic disorder (including active leukemia) for which they have had an exacerbation of symptoms within the past month, or are undergoing a change in treatment. the following cardiac conditions: unstable angina pectoris history of myocardial infarction (mi), coronary bypass surgery, or any percutaneous coronary intervention (pci) within 6 months prior to screening congestive heart failure requiring active treatment with a prescription medication unstable or life-threatening cardiac arrhythmia a. chronic stable atrial fibrillation is allowed subjects with a history of systemic autoimmune diseases (e.g., lupus, inflammatory bowel disease, rheumatoid arthritis, etc.). a. psoriasis confined to the skin and eczema are allowed subjects receiving immunosuppressive therapy including chronic use of supraphysiologic steroids such as prednisone >10 mg daily (however, inhaled corticosteroids and acute use of higher doses of prednisone to treat conditions such as exacerbation of asthma or other acute conditions are allowed). subjects with an immunodeficiency disease, including a history of a positive human immunodeficiency virus (hiv) test result. subjects with a history of gastric bypass surgery. subjects who require treatment with strong cyp3a4 or cyp1a2 inhibitors or inducers, or subjects who require treatment with digoxin. use of any other investigational medication or participation in any other investigational study within 5 half-lives of the investigational medication, or within 30 days, whichever is longer; or longer if required by local regulations.

1. any subject who self-reports: 1. as a current smoker, or stopped smoking within the past 6 months. 2. as a previous smoker with a ≥10 pack year smoking history. 3. has a household member who currently smokes in the house. 2. subjects with a medical history of chronic obstructive pulmonary disease (copd), emphysema or chronic bronchitis requiring active treatment with a prescription medication 3. the subject has already had symptoms consistent with covid-19 at screening. 4. subjects who require chronic supplemental oxygen therapy at screening. 5. subjects with current evidence of an unstable medical disorder including an unstable respiratory disorder, gastrointestinal disorder (including child-pugh class b and c hepatic impairment), renal disorder or hematologic disorder (including active leukemia) for which they have had an exacerbation of symptoms within the past month, or are undergoing a change in treatment. 6. the following cardiac conditions: 1. unstable angina pectoris 2. history of myocardial infarction (mi), coronary bypass surgery, or any percutaneous coronary intervention (pci) within 6 months prior to screening 3. congestive heart failure requiring active treatment with a prescription medication 4. unstable or life-threatening cardiac arrhythmia a. chronic stable atrial fibrillation is allowed 7. subjects with a history of systemic autoimmune diseases (e.g., lupus, inflammatory bowel disease, rheumatoid arthritis, etc.). a. psoriasis confined to the skin and eczema are allowed 8. subjects receiving immunosuppressive therapy including chronic use of supraphysiologic steroids such as prednisone >10 mg daily (however, inhaled corticosteroids and acute use of higher doses of prednisone to treat conditions such as exacerbation of asthma or other acute conditions are allowed). 9. subjects with an immunodeficiency disease, including a history of a positive human immunodeficiency virus (hiv) test result. 10. subjects with a history of gastric bypass surgery. 11. subjects who require treatment with strong cyp3a4 or cyp1a2 inhibitors or inducers, or subjects who require treatment with digoxin. 12. use of any other investigational medication or participation in any other investigational study within 5 half-lives of the investigational medication, or within 30 days, whichever is longer; or longer if required by local regulations.

1. any subject who self-reports: 1. as a current smoker, or stopped smoking within the past 6 months. 2. as a previous smoker with a ≥10 pack year smoking history. 3. has a household member who currently smokes in the house. 2. subjects with a medical history of chronic obstructive pulmonary disease (copd), emphysema or chronic bronchitis requiring active treatment with a prescription medication 3. the subject has already had symptoms consistent with covid-19 at screening. 4. subjects who require chronic supplemental oxygen therapy at screening. 5. subjects with current evidence of an unstable medical disorder including an unstable respiratory disorder, gastrointestinal disorder (including child-pugh class b and c hepatic impairment), renal disorder or hematologic disorder (including active leukemia) for which they have had an exacerbation of symptoms within the past month, or are undergoing a change in treatment. 6. the following cardiac conditions: 1. unstable angina pectoris 2. history of myocardial infarction (mi), coronary bypass surgery, or any percutaneous coronary intervention (pci) within 6 months prior to screening 3. congestive heart failure requiring active treatment with a prescription medication 4. unstable or life-threatening cardiac arrhythmia a. chronic stable atrial fibrillation is allowed 7. subjects with a history of systemic autoimmune diseases (e.g., lupus, inflammatory bowel disease, rheumatoid arthritis, etc.). a. psoriasis confined to the skin and eczema are allowed 8. subjects receiving immunosuppressive therapy including chronic use of supraphysiologic steroids such as prednisone >10 mg daily (however, inhaled corticosteroids and acute use of higher doses of prednisone to treat conditions such as exacerbation of asthma or other acute conditions are allowed). 9. subjects with an immunodeficiency disease, including a history of a positive human immunodeficiency virus (hiv) test result. 10. subjects with a history of gastric bypass surgery. 11. subjects who require treatment with strong cyp3a4 or cyp1a2 inhibitors or inducers, or subjects who require treatment with digoxin. 12. use of any other investigational medication or participation in any other investigational study within 5 half-lives of the investigational medication, or within 30 days, whichever is longer; or longer if required by local regulations.