inclusion criteria:fulfilling all the following criteria 1. olerder than 18. 2. hospitalized participants with diagnosis of covid 19 by real time - polymerase chain reaction. 3. severe cases according to the official guideline "pneumonia diagnosis and treatment scheme for novel coronavirus infection (trial version 7)". 4. sequential organ failure assessment score (sofa) \< 6. 5. ability to understand and the willingness to sign a written informed consent document.

inclusion criteria:fulfilling all the following criteria 1. olerder than 18. 2. hospitalized participants with diagnosis of covid 19 by real time - polymerase chain reaction. 3. severe cases according to the official guideline "pneumonia diagnosis and treatment scheme for novel coronavirus infection (trial version 7)". 4. sequential organ failure assessment score (sofa) \< 6. 5. ability to understand and the willingness to sign a written informed consent document.

inclusion criteria:fulfilling all the following criteria olerder than 18. hospitalized participants with diagnosis of covid 19 by real time - polymerase chain reaction. severe cases according to the official guideline "pneumonia diagnosis and treatment scheme for novel coronavirus infection (trial version 7)". sequential organ failure assessment score (sofa) < 6. ability to understand and the willingness to sign a written informed consent document.

inclusion criteria:fulfilling all the following criteria olerder than 18. hospitalized participants with diagnosis of covid 19 by real time - polymerase chain reaction. severe cases according to the official guideline "pneumonia diagnosis and treatment scheme for novel coronavirus infection (trial version 7)". sequential organ failure assessment score (sofa) < 6. ability to understand and the willingness to sign a written informed consent document.

inclusion criteria:fulfilling all the following criteria 1. olerder than 18. 2. hospitalized participants with diagnosis of covid 19 by real time - polymerase chain reaction. 3. severe cases according to the official guideline "pneumonia diagnosis and treatment scheme for novel coronavirus infection (trial version 7)". 4. sequential organ failure assessment score (sofa) < 6. 5. ability to understand and the willingness to sign a written informed consent document.

inclusion criteria:fulfilling all the following criteria 1. olerder than 18. 2. hospitalized participants with diagnosis of covid 19 by real time - polymerase chain reaction. 3. severe cases according to the official guideline "pneumonia diagnosis and treatment scheme for novel coronavirus infection (trial version 7)". 4. sequential organ failure assessment score (sofa) < 6. 5. ability to understand and the willingness to sign a written informed consent document.