inclusion criteria: * age ≥ 18 years of either gender * confirmed sars-cov-2 infection by rt-pcr * currently diagnosed with mild-to-moderate symptoms of covid-19 at home in self-isolation within 3 days of sars-cov-2 infection. * displaying typical symptoms of covid-19 such as a high temperature, a new, continuous cough, a loss or change to sense of smell or taste * patients who have signed informed consent.

inclusion criteria: * age ≥ 18 years of either gender * confirmed sars-cov-2 infection by rt-pcr * currently diagnosed with mild-to-moderate symptoms of covid-19 at home in self-isolation within 3 days of sars-cov-2 infection. * displaying typical symptoms of covid-19 such as a high temperature, a new, continuous cough, a loss or change to sense of smell or taste * patients who have signed informed consent.

inclusion criteria: - age ≥ 18 years of either gender - confirmed sars-cov-2 infection by rt-pcr - currently diagnosed with mild-to-moderate symptoms of covid-19 at home in self-isolation within 3 days of sars-cov-2 infection. - displaying typical symptoms of covid-19 such as a high temperature, a new, continuous cough, a loss or change to sense of smell or taste - patients who have signed informed consent.

inclusion criteria: - age ≥ 18 years of either gender - confirmed sars-cov-2 infection by rt-pcr - currently diagnosed with mild-to-moderate symptoms of covid-19 at home in self-isolation within 3 days of sars-cov-2 infection. - displaying typical symptoms of covid-19 such as a high temperature, a new, continuous cough, a loss or change to sense of smell or taste - patients who have signed informed consent.

inclusion criteria: - age ≥ 18 years - adult patients with positive sars-cov-2 rt-pcr on nasal swab or deep respiratory sample, diagnosed with moderate-to-severe respiratory acute syndrome (ards) within 10 days, according to berlin definition: - new or worsening of respiratory symptoms within a week of a known clinical insult - radiological imaging (ct, rx, ultrasound) of bilateral pulmonary opacity not fully explained by pouring, lobular or pulmonary atelectasis, or nodules - respiratory failure not fully explained by heart failure or water overload (after exclusion of hydrostatic causes of edema in the absence of risk factors by objective assessment, for example ultrasound) - pao2/fio2 < 300 mmhg with peep (or cpap) ≥ 5 cm h20 - increase of the value of pcr - need or not need for mechanical ventilation and/or cpap - patients who have signed informed consent. in the event of impossibility/inability to obtain informed consent due to the clinical framework (e.g. patients over the age of 18 sedated and treated for acute respiratory failure and subsequent mechanical ventilation) it will be carried out assuming the patient's consent until contrary will is manifest

inclusion criteria: - age ≥ 18 years - adult patients with positive sars-cov-2 rt-pcr on nasal swab or deep respiratory sample, diagnosed with moderate-to-severe respiratory acute syndrome (ards) within 10 days, according to berlin definition: - new or worsening of respiratory symptoms within a week of a known clinical insult - radiological imaging (ct, rx, ultrasound) of bilateral pulmonary opacity not fully explained by pouring, lobular or pulmonary atelectasis, or nodules - respiratory failure not fully explained by heart failure or water overload (after exclusion of hydrostatic causes of edema in the absence of risk factors by objective assessment, for example ultrasound) - pao2/fio2 < 300 mmhg with peep (or cpap) ≥ 5 cm h20 - increase of the value of pcr - need or not need for mechanical ventilation and/or cpap - patients who have signed informed consent. in the event of impossibility/inability to obtain informed consent due to the clinical framework (e.g. patients over the age of 18 sedated and treated for acute respiratory failure and subsequent mechanical ventilation) it will be carried out assuming the patient's consent until contrary will is manifest