* female subjects with positive pregnancy test, are breastfeeding or planning to become pregnant/breastfeed during the study period * symptomatic illness exceeding 14 days from onset of illness at time of enrollment * icu admission on initial presentation at the hospital (includes patients with clinical indications for icu admission as follows: 1. respiratory distress with requirement of o2 \>6 lpm to maintain o2 sat \>92% 2. rapid escalation of o2 requirement/significant work of breathing 3. hemodynamic instability: sbp \<90, map \<65 * receipt of any blood products including pooled immunoglobulin or intravenous immunoglobulin (ivig) in the past 30 days prior to enrolment * known iga deficiency * presence of any contraindication to transfusion (or history of prior severe reactions to transfusion of blood products)

* female subjects with positive pregnancy test, are breastfeeding or planning to become pregnant/breastfeed during the study period * symptomatic illness exceeding 14 days from onset of illness at time of enrollment * icu admission on initial presentation at the hospital (includes patients with clinical indications for icu admission as follows: 1. respiratory distress with requirement of o2 \>6 lpm to maintain o2 sat \>92% 2. rapid escalation of o2 requirement/significant work of breathing 3. hemodynamic instability: sbp \<90, map \<65 * receipt of any blood products including pooled immunoglobulin or intravenous immunoglobulin (ivig) in the past 30 days prior to enrolment * known iga deficiency * presence of any contraindication to transfusion (or history of prior severe reactions to transfusion of blood products)

female subjects with positive pregnancy test, are breastfeeding or planning to become pregnant/breastfeed during the study period symptomatic illness exceeding 14 days from onset of illness at time of enrollment icu admission on initial presentation at the hospital (includes patients with clinical indications for icu admission as follows: respiratory distress with requirement of o2 >6 lpm to maintain o2 sat >92% rapid escalation of o2 requirement/significant work of breathing hemodynamic instability: sbp <90, map <65 receipt of any blood products including pooled immunoglobulin or intravenous immunoglobulin (ivig) in the past 30 days prior to enrolment known iga deficiency presence of any contraindication to transfusion (or history of prior severe reactions to transfusion of blood products)

female subjects with positive pregnancy test, are breastfeeding or planning to become pregnant/breastfeed during the study period symptomatic illness exceeding 14 days from onset of illness at time of enrollment icu admission on initial presentation at the hospital (includes patients with clinical indications for icu admission as follows: respiratory distress with requirement of o2 >6 lpm to maintain o2 sat >92% rapid escalation of o2 requirement/significant work of breathing hemodynamic instability: sbp <90, map <65 receipt of any blood products including pooled immunoglobulin or intravenous immunoglobulin (ivig) in the past 30 days prior to enrolment known iga deficiency presence of any contraindication to transfusion (or history of prior severe reactions to transfusion of blood products)

- female subjects with positive pregnancy test, are breastfeeding or planning to become pregnant/breastfeed during the study period - symptomatic illness exceeding 14 days from onset of illness at time of enrollment - icu admission on initial presentation at the hospital (includes patients with clinical indications for icu admission as follows: 1. respiratory distress with requirement of o2 >6 lpm to maintain o2 sat >92% 2. rapid escalation of o2 requirement/significant work of breathing 3. hemodynamic instability: sbp <90, map <65 - receipt of any blood products including pooled immunoglobulin or intravenous immunoglobulin (ivig) in the past 30 days prior to enrolment - known iga deficiency - presence of any contraindication to transfusion (or history of prior severe reactions to transfusion of blood products)

- female subjects with positive pregnancy test, are breastfeeding or planning to become pregnant/breastfeed during the study period - symptomatic illness exceeding 14 days from onset of illness at time of enrollment - icu admission on initial presentation at the hospital (includes patients with clinical indications for icu admission as follows: 1. respiratory distress with requirement of o2 >6 lpm to maintain o2 sat >92% 2. rapid escalation of o2 requirement/significant work of breathing 3. hemodynamic instability: sbp <90, map <65 - receipt of any blood products including pooled immunoglobulin or intravenous immunoglobulin (ivig) in the past 30 days prior to enrolment - known iga deficiency - presence of any contraindication to transfusion (or history of prior severe reactions to transfusion of blood products)