* greater than 72 hours since time of onset of ards. * greater than 7 days since start of mechanical ventilation. * currently receiving or anticipated to receive extracorporeal life support (ecls), extracorporeal membrane oxygenation (ecmo) or high-frequency oscillatory ventilation * unwillingness to follow lung protective ventilation strategy (i.e., tidal volume of 6 ml/kg of predicted body weight and prone positioning) and fluid management protocol (fluids and catheters treatment trial \[factt\] conservative or lite) per local institutional standards (hfov).

* greater than 72 hours since time of onset of ards. * greater than 7 days since start of mechanical ventilation. * currently receiving or anticipated to receive extracorporeal life support (ecls), extracorporeal membrane oxygenation (ecmo) or high-frequency oscillatory ventilation * unwillingness to follow lung protective ventilation strategy (i.e., tidal volume of 6 ml/kg of predicted body weight and prone positioning) and fluid management protocol (fluids and catheters treatment trial \[factt\] conservative or lite) per local institutional standards (hfov).

- greater than 72 hours since time of onset of ards. - greater than 7 days since start of mechanical ventilation. - currently receiving or anticipated to receive extracorporeal life support (ecls), extracorporeal membrane oxygenation (ecmo) or high-frequency oscillatory ventilation - unwillingness to follow lung protective ventilation strategy (i.e., tidal volume of 6 ml/kg of predicted body weight and prone positioning) and fluid management protocol (fluids and catheters treatment trial [factt] conservative or lite) per local institutional standards (hfov).

- greater than 72 hours since time of onset of ards. - greater than 7 days since start of mechanical ventilation. - currently receiving or anticipated to receive extracorporeal life support (ecls), extracorporeal membrane oxygenation (ecmo) or high-frequency oscillatory ventilation - unwillingness to follow lung protective ventilation strategy (i.e., tidal volume of 6 ml/kg of predicted body weight and prone positioning) and fluid management protocol (fluids and catheters treatment trial [factt] conservative or lite) per local institutional standards (hfov).