inclusion criteria: * the subject's written informed consent to participate in the study; * male and female subjects between the ages of 18 and 60 years (inclusive). * a negative test result for hiv, hepatitis, syphilis; * negative result of research on antibodies igm and igg to sars cov2 by enzyme-linked immunosorbent assay; * a negative result of the covid-2019 study, as determined by the pcr method at the screening visit; * lack of covid-2019 in anamnesis; * lack of contact of the subject with covid-2019 patients for at least 14 days before inclusion in the study (according to the participant); * agreement to use effective contraceptive methods throughout the study period; * negative pregnancy test based on the results of a urine test at a screening visit (for women of childbearing age); * a negative test for the presence of narcotic substances and psycho-stimulating drugs in the urine at the screening visit; * negative alcohol test at the screening visit; * lack of pre-existing post-vaccination reactions or post-vaccination complications following the use of immunobiological drugs; * no acute infectious and/or respiratory diseases for at least 14 days before inclusion in the study.

inclusion criteria: * the subject's written informed consent to participate in the study; * male and female subjects between the ages of 18 and 60 years (inclusive). * a negative test result for hiv, hepatitis, syphilis; * negative result of research on antibodies igm and igg to sars cov2 by enzyme-linked immunosorbent assay; * a negative result of the covid-2019 study, as determined by the pcr method at the screening visit; * lack of covid-2019 in anamnesis; * lack of contact of the subject with covid-2019 patients for at least 14 days before inclusion in the study (according to the participant); * agreement to use effective contraceptive methods throughout the study period; * negative pregnancy test based on the results of a urine test at a screening visit (for women of childbearing age); * a negative test for the presence of narcotic substances and psycho-stimulating drugs in the urine at the screening visit; * negative alcohol test at the screening visit; * lack of pre-existing post-vaccination reactions or post-vaccination complications following the use of immunobiological drugs; * no acute infectious and/or respiratory diseases for at least 14 days before inclusion in the study.

inclusion criteria: - the subject's written informed consent to participate in the study; - male and female subjects between the ages of 18 and 60 years (inclusive). - a negative test result for hiv, hepatitis, syphilis; - negative result of research on antibodies igm and igg to sars cov2 by enzyme-linked immunosorbent assay; - a negative result of the covid-2019 study, as determined by the pcr method at the screening visit; - lack of covid-2019 in anamnesis; - lack of contact of the subject with covid-2019 patients for at least 14 days before inclusion in the study (according to the participant); - agreement to use effective contraceptive methods throughout the study period; - negative pregnancy test based on the results of a urine test at a screening visit (for women of childbearing age); - a negative test for the presence of narcotic substances and psycho-stimulating drugs in the urine at the screening visit; - negative alcohol test at the screening visit; - lack of pre-existing post-vaccination reactions or post-vaccination complications following the use of immunobiological drugs; - no acute infectious and/or respiratory diseases for at least 14 days before inclusion in the study.

inclusion criteria: - the subject's written informed consent to participate in the study; - male and female subjects between the ages of 18 and 60 years (inclusive). - a negative test result for hiv, hepatitis, syphilis; - negative result of research on antibodies igm and igg to sars cov2 by enzyme-linked immunosorbent assay; - a negative result of the covid-2019 study, as determined by the pcr method at the screening visit; - lack of covid-2019 in anamnesis; - lack of contact of the subject with covid-2019 patients for at least 14 days before inclusion in the study (according to the participant); - agreement to use effective contraceptive methods throughout the study period; - negative pregnancy test based on the results of a urine test at a screening visit (for women of childbearing age); - a negative test for the presence of narcotic substances and psycho-stimulating drugs in the urine at the screening visit; - negative alcohol test at the screening visit; - lack of pre-existing post-vaccination reactions or post-vaccination complications following the use of immunobiological drugs; - no acute infectious and/or respiratory diseases for at least 14 days before inclusion in the study.