inclusion criteria: * healthy subjects aged between 18 and 85 years old. * by asking for medical history and physical examination, the investigator judged that the health condition is well. * female subjects of childbearing age are not nursing or pregnant at the time of enrolment (negative urine pregnancy test) and have no family planning within the first 3 months after enrolment. effective contraceptive measures have been taken within 2 weeks before inclusion. * during the whole follow-up period of the study, be able and willing to complete the whole prescribed study plan. * with self-ability to understand the study procedures, the informed consent \& voluntarily sign an informed consent form and be able to comply with the requirements of the protocol.

inclusion criteria: * healthy subjects aged between 18 and 85 years old. * by asking for medical history and physical examination, the investigator judged that the health condition is well. * female subjects of childbearing age are not nursing or pregnant at the time of enrolment (negative urine pregnancy test) and have no family planning within the first 3 months after enrolment. effective contraceptive measures have been taken within 2 weeks before inclusion. * during the whole follow-up period of the study, be able and willing to complete the whole prescribed study plan. * with self-ability to understand the study procedures, the informed consent \& voluntarily sign an informed consent form and be able to comply with the requirements of the protocol.

inclusion criteria: - healthy subjects aged between 18 and 85 years old. - by asking for medical history and physical examination, the investigator judged that the health condition is well. - female subjects of childbearing age are not nursing or pregnant at the time of enrolment (negative urine pregnancy test) and have no family planning within the first 3 months after enrolment. effective contraceptive measures have been taken within 2 weeks before inclusion. - during the whole follow-up period of the study, be able and willing to complete the whole prescribed study plan. - with self-ability to understand the study procedures, the informed consent & voluntarily sign an informed consent form and be able to comply with the requirements of the protocol.

inclusion criteria: - healthy subjects aged between 18 and 85 years old. - by asking for medical history and physical examination, the investigator judged that the health condition is well. - female subjects of childbearing age are not nursing or pregnant at the time of enrolment (negative urine pregnancy test) and have no family planning within the first 3 months after enrolment. effective contraceptive measures have been taken within 2 weeks before inclusion. - during the whole follow-up period of the study, be able and willing to complete the whole prescribed study plan. - with self-ability to understand the study procedures, the informed consent & voluntarily sign an informed consent form and be able to comply with the requirements of the protocol.