1. pregnant women 2. breastfeeding mother 3. patients with markedly elevated liver enzyme (alt and/or ast) of more than three times from baseline level 4. reduced kidney function with estimated glomerular filtration rate (egfr) \<30 ml/min or serum creatinine \> 2 mg/dl 5. patients with history of heart failure 6. tuberculosis infection that was treated with pyrazinamide 7. asthma that was treated with theophylline 8. type 2 diabetes that was treated with repaglinid

1. pregnant women 2. breastfeeding mother 3. patients with markedly elevated liver enzyme (alt and/or ast) of more than three times from baseline level 4. reduced kidney function with estimated glomerular filtration rate (egfr) \<30 ml/min or serum creatinine \> 2 mg/dl 5. patients with history of heart failure 6. tuberculosis infection that was treated with pyrazinamide 7. asthma that was treated with theophylline 8. type 2 diabetes that was treated with repaglinid

pregnant women breastfeeding mother patients with markedly elevated liver enzyme (alt and/or ast) of more than three times from baseline level reduced kidney function with estimated glomerular filtration rate (egfr) <30 ml/min or serum creatinine > 2 mg/dl patients with history of heart failure tuberculosis infection that was treated with pyrazinamide asthma that was treated with theophylline type 2 diabetes that was treated with repaglinid

pregnant women breastfeeding mother patients with markedly elevated liver enzyme (alt and/or ast) of more than three times from baseline level reduced kidney function with estimated glomerular filtration rate (egfr) <30 ml/min or serum creatinine > 2 mg/dl patients with history of heart failure tuberculosis infection that was treated with pyrazinamide asthma that was treated with theophylline type 2 diabetes that was treated with repaglinid

1. pregnant women 2. breastfeeding mother 3. patients with markedly elevated liver enzyme (alt and/or ast) of more than three times from baseline level 4. reduced kidney function with estimated glomerular filtration rate (egfr) <30 ml/min or serum creatinine > 2 mg/dl 5. patients with history of heart failure 6. tuberculosis infection that was treated with pyrazinamide 7. asthma that was treated with theophylline 8. type 2 diabetes that was treated with repaglinid

1. pregnant women 2. breastfeeding mother 3. patients with markedly elevated liver enzyme (alt and/or ast) of more than three times from baseline level 4. reduced kidney function with estimated glomerular filtration rate (egfr) <30 ml/min or serum creatinine > 2 mg/dl 5. patients with history of heart failure 6. tuberculosis infection that was treated with pyrazinamide 7. asthma that was treated with theophylline 8. type 2 diabetes that was treated with repaglinid