inclusion criteria: 1. age equal to or greater than 18 yers; 2. diagnosis of sars-cov-2 infection through nasal cavity or oropharynx swab rt-pcr; 3. severe covid-19 defined by the presence of at least 1 of the following: a. respiratory rate\> 30 breaths per minute in room air; b. oxygen saturation (o2) ≤93% in room air; c. pao2 / fio2 ratio ≤300; d. need for supplemental o2 to maintain o2 saturation\> 95%; e. need for therapy with supplemental o2 by high flow catheter or non-invasive ventilation or invasive mechanical ventilation; 4. onset of symptoms in a period not exceeding 14 days.

inclusion criteria: 1. age equal to or greater than 18 yers; 2. diagnosis of sars-cov-2 infection through nasal cavity or oropharynx swab rt-pcr; 3. severe covid-19 defined by the presence of at least 1 of the following: a. respiratory rate\> 30 breaths per minute in room air; b. oxygen saturation (o2) ≤93% in room air; c. pao2 / fio2 ratio ≤300; d. need for supplemental o2 to maintain o2 saturation\> 95%; e. need for therapy with supplemental o2 by high flow catheter or non-invasive ventilation or invasive mechanical ventilation; 4. onset of symptoms in a period not exceeding 14 days.

inclusion criteria: age equal to or greater than 18 yers; diagnosis of sars-cov-2 infection through nasal cavity or oropharynx swab rt-pcr; severe covid-19 defined by the presence of at least 1 of the following: a. respiratory rate> 30 breaths per minute in room air; b. oxygen saturation (o2) ≤93% in room air; c. pao2 / fio2 ratio ≤300; d. need for supplemental o2 to maintain o2 saturation> 95%; e. need for therapy with supplemental o2 by high flow catheter or non-invasive ventilation or invasive mechanical ventilation; onset of symptoms in a period not exceeding 14 days.

inclusion criteria: age equal to or greater than 18 yers; diagnosis of sars-cov-2 infection through nasal cavity or oropharynx swab rt-pcr; severe covid-19 defined by the presence of at least 1 of the following: a. respiratory rate> 30 breaths per minute in room air; b. oxygen saturation (o2) ≤93% in room air; c. pao2 / fio2 ratio ≤300; d. need for supplemental o2 to maintain o2 saturation> 95%; e. need for therapy with supplemental o2 by high flow catheter or non-invasive ventilation or invasive mechanical ventilation; onset of symptoms in a period not exceeding 14 days.

inclusion criteria: 1. age equal to or greater than 18 yers; 2. diagnosis of sars-cov-2 infection through nasal cavity or oropharynx swab rt-pcr; 3. severe covid-19 defined by the presence of at least 1 of the following: a. respiratory rate> 30 breaths per minute in room air; b. oxygen saturation (o2) ≤93% in room air; c. pao2 / fio2 ratio ≤300; d. need for supplemental o2 to maintain o2 saturation> 95%; e. need for therapy with supplemental o2 by high flow catheter or non-invasive ventilation or invasive mechanical ventilation; 4. onset of symptoms in a period not exceeding 14 days.

inclusion criteria: 1. age equal to or greater than 18 yers; 2. diagnosis of sars-cov-2 infection through nasal cavity or oropharynx swab rt-pcr; 3. severe covid-19 defined by the presence of at least 1 of the following: a. respiratory rate> 30 breaths per minute in room air; b. oxygen saturation (o2) ≤93% in room air; c. pao2 / fio2 ratio ≤300; d. need for supplemental o2 to maintain o2 saturation> 95%; e. need for therapy with supplemental o2 by high flow catheter or non-invasive ventilation or invasive mechanical ventilation; 4. onset of symptoms in a period not exceeding 14 days.