* clinical evidence of any significant acute or chronic disease that, in the opinion of the investigator, may place the subject at undue medical risk. * the subject has had a known serious anaphylactic reaction to blood, any blood-derived or plasma product or methylene blue. * a medical condition in which the infusion of additional fluid is contraindicated. * shock unresponsive to fluid challenge and/or multiple vasopressors and accompanied by multiorgan failure considered by the principal investigator not able to be reversed.

* clinical evidence of any significant acute or chronic disease that, in the opinion of the investigator, may place the subject at undue medical risk. * the subject has had a known serious anaphylactic reaction to blood, any blood-derived or plasma product or methylene blue. * a medical condition in which the infusion of additional fluid is contraindicated. * shock unresponsive to fluid challenge and/or multiple vasopressors and accompanied by multiorgan failure considered by the principal investigator not able to be reversed.

- clinical evidence of any significant acute or chronic disease that, in the opinion of the investigator, may place the subject at undue medical risk. - the subject has had a known serious anaphylactic reaction to blood, any blood-derived or plasma product or methylene blue. - a medical condition in which the infusion of additional fluid is contraindicated. - shock unresponsive to fluid challenge and/or multiple vasopressors and accompanied by multiorgan failure considered by the principal investigator not able to be reversed.

- clinical evidence of any significant acute or chronic disease that, in the opinion of the investigator, may place the subject at undue medical risk. - the subject has had a known serious anaphylactic reaction to blood, any blood-derived or plasma product or methylene blue. - a medical condition in which the infusion of additional fluid is contraindicated. - shock unresponsive to fluid challenge and/or multiple vasopressors and accompanied by multiorgan failure considered by the principal investigator not able to be reversed.