1. history of anaphylaxis, urticarial, or other significant adverse reaction requiring medical intervention after receipt of a vaccine. 2. female who is pregnant or positive in pregnancy test at screening or just prior to each vaccination administration. 3. female who is breast-feeding or plans to breastfeed from the time of the first vaccination through 60 days after the last vaccination. 4. any acute illness, as determined by the study investigator 3 days before first vaccination. 5. evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or allergic disease. 6. known history of sars or mers. 7. previous exposure to sars-cov-2 or receipt of an investigational vaccine product for the prevention of covid-19, mers or sars. 8. subjects who take part in another clinical study within 12 weeks prior to the day of informed consent. 9. with certain underlying medical conditions which are at increased risk for severe illness from covid-19. 10. congenital or acquired angioedema. 11. immune deficiency/disorder, whether due to genetic defect, immunodeficiency disease or immunosuppressive therapy. 12. platelet disorder or other bleeding disorder may cause injection contraindication. 13. prior chronic administration of immunosuppressant or corticosteroids, cytotoxic treatment in last 6 months before first vaccination. 14. prior administration of immunoglobulins and/or any blood products in last 4 months before first vaccination. 15. prior administration of attenuated, nucleic acid (mrna or dna) or vectored vaccines in last 1 month before first vaccination or expectation of such vaccines in the month after the second vaccination. 16. prior administration of subunit vaccine or inactivated vaccine in last 14 days before first vaccination or expectation of receipt of such vaccines in the 14 days after the second vaccination. 17. current anti-tuberculosis (tb) therapy or history of tb. 18. alcoholism or substance abuser. 19. history of malignancy within 5 years prior to screening visit, except basal cell carcinoma of the skin and cervical carcinoma in situ. 20. any medical disease or condition that, in the opinion of the study investigator, may confound the results of the study or pose an additional risk to the subjects by their participation in the study.

1. history of anaphylaxis, urticarial, or other significant adverse reaction requiring medical intervention after receipt of a vaccine. 2. female who is pregnant or positive in pregnancy test at screening or just prior to each vaccination administration. 3. female who is breast-feeding or plans to breastfeed from the time of the first vaccination through 60 days after the last vaccination. 4. any acute illness, as determined by the study investigator 3 days before first vaccination. 5. evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or allergic disease. 6. known history of sars or mers. 7. previous exposure to sars-cov-2 or receipt of an investigational vaccine product for the prevention of covid-19, mers or sars. 8. subjects who take part in another clinical study within 12 weeks prior to the day of informed consent. 9. with certain underlying medical conditions which are at increased risk for severe illness from covid-19. 10. congenital or acquired angioedema. 11. immune deficiency/disorder, whether due to genetic defect, immunodeficiency disease or immunosuppressive therapy. 12. platelet disorder or other bleeding disorder may cause injection contraindication. 13. prior chronic administration of immunosuppressant or corticosteroids, cytotoxic treatment in last 6 months before first vaccination. 14. prior administration of immunoglobulins and/or any blood products in last 4 months before first vaccination. 15. prior administration of attenuated, nucleic acid (mrna or dna) or vectored vaccines in last 1 month before first vaccination or expectation of such vaccines in the month after the second vaccination. 16. prior administration of subunit vaccine or inactivated vaccine in last 14 days before first vaccination or expectation of receipt of such vaccines in the 14 days after the second vaccination. 17. current anti-tuberculosis (tb) therapy or history of tb. 18. alcoholism or substance abuser. 19. history of malignancy within 5 years prior to screening visit, except basal cell carcinoma of the skin and cervical carcinoma in situ. 20. any medical disease or condition that, in the opinion of the study investigator, may confound the results of the study or pose an additional risk to the subjects by their participation in the study.

history of anaphylaxis, urticarial, or other significant adverse reaction requiring medical intervention after receipt of a vaccine. female who is pregnant or positive in pregnancy test at screening or just prior to each vaccination administration. female who is breast-feeding or plans to breastfeed from the time of the first vaccination through 60 days after the last vaccination. any acute illness, as determined by the study investigator 3 days before first vaccination. evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or allergic disease. known history of sars or mers. previous exposure to sars-cov-2 or receipt of an investigational vaccine product for the prevention of covid-19, mers or sars. subjects who take part in another clinical study within 12 weeks prior to the day of informed consent. with certain underlying medical conditions which are at increased risk for severe illness from covid-19. congenital or acquired angioedema. immune deficiency/disorder, whether due to genetic defect, immunodeficiency disease or immunosuppressive therapy. platelet disorder or other bleeding disorder may cause injection contraindication. prior chronic administration of immunosuppressant or corticosteroids, cytotoxic treatment in last 6 months before first vaccination. prior administration of immunoglobulins and/or any blood products in last 4 months before first vaccination. prior administration of attenuated, nucleic acid (mrna or dna) or vectored vaccines in last 1 month before first vaccination or expectation of such vaccines in the month after the second vaccination. prior administration of subunit vaccine or inactivated vaccine in last 14 days before first vaccination or expectation of receipt of such vaccines in the 14 days after the second vaccination. current anti-tuberculosis (tb) therapy or history of tb. alcoholism or substance abuser. history of malignancy within 5 years prior to screening visit, except basal cell carcinoma of the skin and cervical carcinoma in situ. any medical disease or condition that, in the opinion of the study investigator, may confound the results of the study or pose an additional risk to the subjects by their participation in the study.

history of anaphylaxis, urticarial, or other significant adverse reaction requiring medical intervention after receipt of a vaccine. female who is pregnant or positive in pregnancy test at screening or just prior to each vaccination administration. female who is breast-feeding or plans to breastfeed from the time of the first vaccination through 60 days after the last vaccination. any acute illness, as determined by the study investigator 3 days before first vaccination. evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or allergic disease. known history of sars or mers. previous exposure to sars-cov-2 or receipt of an investigational vaccine product for the prevention of covid-19, mers or sars. subjects who take part in another clinical study within 12 weeks prior to the day of informed consent. with certain underlying medical conditions which are at increased risk for severe illness from covid-19. congenital or acquired angioedema. immune deficiency/disorder, whether due to genetic defect, immunodeficiency disease or immunosuppressive therapy. platelet disorder or other bleeding disorder may cause injection contraindication. prior chronic administration of immunosuppressant or corticosteroids, cytotoxic treatment in last 6 months before first vaccination. prior administration of immunoglobulins and/or any blood products in last 4 months before first vaccination. prior administration of attenuated, nucleic acid (mrna or dna) or vectored vaccines in last 1 month before first vaccination or expectation of such vaccines in the month after the second vaccination. prior administration of subunit vaccine or inactivated vaccine in last 14 days before first vaccination or expectation of receipt of such vaccines in the 14 days after the second vaccination. current anti-tuberculosis (tb) therapy or history of tb. alcoholism or substance abuser. history of malignancy within 5 years prior to screening visit, except basal cell carcinoma of the skin and cervical carcinoma in situ. any medical disease or condition that, in the opinion of the study investigator, may confound the results of the study or pose an additional risk to the subjects by their participation in the study.

1. history of anaphylaxis, urticarial, or other significant adverse reaction requiring medical intervention after receipt of a vaccine. 2. female who is pregnant or positive in pregnancy test at screening or just prior to each vaccination administration. 3. female who is breast-feeding or plans to breastfeed from the time of the first vaccination through 60 days after the last vaccination. 4. any acute illness, as determined by the study investigator 3 days before first vaccination. 5. evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or allergic disease. 6. known history of sars or mers. 7. previous exposure to sars-cov-2 or receipt of an investigational vaccine product for the prevention of covid-19, mers or sars. 8. subjects who take part in another clinical study within 12 weeks prior to the day of informed consent. 9. with certain underlying medical conditions which are at increased risk for severe illness from covid-19. 10. congenital or acquired angioedema. 11. immune deficiency/disorder, whether due to genetic defect, immunodeficiency disease or immunosuppressive therapy. 12. platelet disorder or other bleeding disorder may cause injection contraindication. 13. prior chronic administration of immunosuppressant or corticosteroids, cytotoxic treatment in last 6 months before first vaccination. 14. prior administration of immunoglobulins and/or any blood products in last 4 months before first vaccination. 15. prior administration of attenuated, nucleic acid (mrna or dna) or vectored vaccines in last 1 month before first vaccination or expectation of such vaccines in the month after the second vaccination. 16. prior administration of subunit vaccine or inactivated vaccine in last 14 days before first vaccination or expectation of receipt of such vaccines in the 14 days after the second vaccination. 17. current anti-tuberculosis (tb) therapy or history of tb. 18. alcoholism or substance abuser. 19. history of malignancy within 5 years prior to screening visit, except basal cell carcinoma of the skin and cervical carcinoma in situ. 20. any medical disease or condition that, in the opinion of the study investigator, may confound the results of the study or pose an additional risk to the subjects by their participation in the study.

1. history of anaphylaxis, urticarial, or other significant adverse reaction requiring medical intervention after receipt of a vaccine. 2. female who is pregnant or positive in pregnancy test at screening or just prior to each vaccination administration. 3. female who is breast-feeding or plans to breastfeed from the time of the first vaccination through 60 days after the last vaccination. 4. any acute illness, as determined by the study investigator 3 days before first vaccination. 5. evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or allergic disease. 6. known history of sars or mers. 7. previous exposure to sars-cov-2 or receipt of an investigational vaccine product for the prevention of covid-19, mers or sars. 8. subjects who take part in another clinical study within 12 weeks prior to the day of informed consent. 9. with certain underlying medical conditions which are at increased risk for severe illness from covid-19. 10. congenital or acquired angioedema. 11. immune deficiency/disorder, whether due to genetic defect, immunodeficiency disease or immunosuppressive therapy. 12. platelet disorder or other bleeding disorder may cause injection contraindication. 13. prior chronic administration of immunosuppressant or corticosteroids, cytotoxic treatment in last 6 months before first vaccination. 14. prior administration of immunoglobulins and/or any blood products in last 4 months before first vaccination. 15. prior administration of attenuated, nucleic acid (mrna or dna) or vectored vaccines in last 1 month before first vaccination or expectation of such vaccines in the month after the second vaccination. 16. prior administration of subunit vaccine or inactivated vaccine in last 14 days before first vaccination or expectation of receipt of such vaccines in the 14 days after the second vaccination. 17. current anti-tuberculosis (tb) therapy or history of tb. 18. alcoholism or substance abuser. 19. history of malignancy within 5 years prior to screening visit, except basal cell carcinoma of the skin and cervical carcinoma in situ. 20. any medical disease or condition that, in the opinion of the study investigator, may confound the results of the study or pose an additional risk to the subjects by their participation in the study.