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                    <a href="?cresstrial=18426&amp;modal=1&amp;valnames=primary_outcome&amp;order=created_at">Created at</a>
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                <th scope="col">Source</th>
                
                <th scope="col">Raw Value</th>
                <th scope="col">Validated value</th>
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            <tr class="histvalue-row" histvalueid="474231" class="table-">
                
                <td>July 8, 2023, 8 a.m.</td>
                <td>usa</td>
                
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        <p class="primary_outcome">
            To characterise the Serum Pharmacokinetics of AZD3152 - Area under the concentration-time curve at the last measured time point (AUClast);To characterise the Serum Pharmacokinetics of AZD3152 - Area under the concentration-time curve from time zero extrapolated to infinity (AUCinf);To characterise the Serum Pharmacokinetics of AZD3152 - Concentration at the end of infusion (Ceoi) (after intravenous only);To characterise the Serum Pharmacokinetics of AZD3152 - Maximum concentration (Cmax);To characterise the Serum Pharmacokinetics of AZD3152 - Terminal half-life (t½);To characterise the Serum Pharmacokinetics of AZD3152 - Time to maximum concentration (tmax);To evaluate the safety and tolerability of AZD3152 - AEs;To evaluate the safety and tolerability of AZD3152 - Alkaline phosphatase;To evaluate the safety and tolerability of AZD3152 - Axillary temperature;To evaluate the safety and tolerability of AZD3152 - Blood pressure;To evaluate the safety and tolerability of AZD3152 - Coagulation - Activated partial thrombin time;To evaluate the safety and tolerability of AZD3152 - Coagulation - International normalised ratio;To evaluate the safety and tolerability of AZD3152 - Coagulation - Prothrombin time;To evaluate the safety and tolerability of AZD3152 - Haematology - Basophils absolute count;To evaluate the safety and tolerability of AZD3152 - Haematology - Eosinophils absolute count;To evaluate the safety and tolerability of AZD3152 - Haematology - Haematocrit;To evaluate the safety and tolerability of AZD3152 - Haematology - Haemoglobin;To evaluate the safety and tolerability of AZD3152 - Haematology - Lymphocytes absolute count;To evaluate the safety and tolerability of AZD3152 - Haematology - Mean corpuscular haemoglobin;To evaluate the safety and tolerability of AZD3152 - Haematology - Mean corpuscular haemoglobin concentration;To evaluate the safety and tolerability of AZD3152 - Haematology - Mean corpuscular volume;To evaluate the safety and tolerability of AZD3152 - Haematology - Monocytes absolute count;To evaluate the safety and tolerability of AZD3152 - Haematology - Neutrophils absolute count;To evaluate the safety and tolerability of AZD3152 - Haematology - Platelets;To evaluate the safety and tolerability of AZD3152 - Haematology - Red blood cell count;To evaluate the safety and tolerability of AZD3152 - Haematology - Reticulocytes absolute count;To evaluate the safety and tolerability of AZD3152 - Haematology - White blood cell count;To evaluate the safety and tolerability of AZD3152 - Heart rate;To evaluate the safety and tolerability of AZD3152 - PR Interval, QRS Duration, QT Interval, QTcF Interval and RR Interval;To evaluate the safety and tolerability of AZD3152 - Pulse rate;To evaluate the safety and tolerability of AZD3152 - Respiratory rate;To evaluate the safety and tolerability of AZD3152 - SAEs, MAAEs, and AESIs;To evaluate the safety and tolerability of AZD3152 - Serum Clincal Chemistry - Alanine aminotransferase;To evaluate the safety and tolerability of AZD3152 - Serum Clincal Chemistry - Albumin;To evaluate the safety and tolerability of AZD3152 - Serum Clincal Chemistry - Aspartate aminotransferase;To evaluate the safety and tolerability of AZD3152 - Serum Clincal Chemistry - Blood urea nitrogen;To evaluate the safety and tolerability of AZD3152 - Serum Clincal Chemistry - Calcium;To evaluate the safety and tolerability of AZD3152 - Serum Clincal Chemistry - Conjugated bilirubin;To evaluate the safety and tolerability of AZD3152 - Serum Clincal Chemistry - C reactive protein;To evaluate the safety and tolerability of AZD3152 - Serum Clincal Chemistry - Creatine kinase;To evaluate the safety and tolerability of AZD3152 - Serum Clincal Chemistry - Creatinine and estimated glomerular filtration rate;To evaluate the safety and tolerability of AZD3152 - Serum Clincal Chemistry - Gamma glutamyl transpeptidase;To evaluate the safety and tolerability of AZD3152 - Serum Clincal Chemistry - Glucose;To evaluate the safety and tolerability of AZD3152 - Serum Clincal Chemistry - Phosphate;To evaluate the safety and tolerability of AZD3152 - Serum Clincal Chemistry - Potassium;To evaluate the safety and tolerability of AZD3152 - Serum Clincal Chemistry - Sodium;To evaluate the safety and tolerability of AZD3152 - Serum Clincal Chemistry - Total bilirubin;To evaluate the safety and tolerability of AZD3152 - Serum Clincal Chemistry - Troponin T and I;To evaluate the safety and tolerability of AZD3152 - Serum Clincal Chemistry - Unconjugated bilirubin;To evaluate the safety and tolerability of AZD3152 - Urinalysis - Blood;To evaluate the safety and tolerability of AZD3152 - Urinalysis - Glucose;To evaluate the safety and tolerability of AZD3152 - Urinalysis - Microscopy;To evaluate the safety and tolerability of AZD3152 - Urinalysis - Protein
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        <p class="primary_outcome validated">
            To characterise the Serum Pharmacokinetics of AZD3152 - Area under the concentration-time curve at the last measured time point (AUClast);To characterise the Serum Pharmacokinetics of AZD3152 - Area under the concentration-time curve from time zero extrapolated to infinity (AUCinf);To characterise the Serum Pharmacokinetics of AZD3152 - Concentration at the end of infusion (Ceoi) (after intravenous only);To characterise the Serum Pharmacokinetics of AZD3152 - Maximum concentration (Cmax);To characterise the Serum Pharmacokinetics of AZD3152 - Terminal half-life (t½);To characterise the Serum Pharmacokinetics of AZD3152 - Time to maximum concentration (tmax);To evaluate the safety and tolerability of AZD3152 - AEs;To evaluate the safety and tolerability of AZD3152 - Alkaline phosphatase;To evaluate the safety and tolerability of AZD3152 - Axillary temperature;To evaluate the safety and tolerability of AZD3152 - Blood pressure;To evaluate the safety and tolerability of AZD3152 - Coagulation - Activated partial thrombin time;To evaluate the safety and tolerability of AZD3152 - Coagulation - International normalised ratio;To evaluate the safety and tolerability of AZD3152 - Coagulation - Prothrombin time;To evaluate the safety and tolerability of AZD3152 - Haematology - Basophils absolute count;To evaluate the safety and tolerability of AZD3152 - Haematology - Eosinophils absolute count;To evaluate the safety and tolerability of AZD3152 - Haematology - Haematocrit;To evaluate the safety and tolerability of AZD3152 - Haematology - Haemoglobin;To evaluate the safety and tolerability of AZD3152 - Haematology - Lymphocytes absolute count;To evaluate the safety and tolerability of AZD3152 - Haematology - Mean corpuscular haemoglobin;To evaluate the safety and tolerability of AZD3152 - Haematology - Mean corpuscular haemoglobin concentration;To evaluate the safety and tolerability of AZD3152 - Haematology - Mean corpuscular volume;To evaluate the safety and tolerability of AZD3152 - Haematology - Monocytes absolute count;To evaluate the safety and tolerability of AZD3152 - Haematology - Neutrophils absolute count;To evaluate the safety and tolerability of AZD3152 - Haematology - Platelets;To evaluate the safety and tolerability of AZD3152 - Haematology - Red blood cell count;To evaluate the safety and tolerability of AZD3152 - Haematology - Reticulocytes absolute count;To evaluate the safety and tolerability of AZD3152 - Haematology - White blood cell count;To evaluate the safety and tolerability of AZD3152 - Heart rate;To evaluate the safety and tolerability of AZD3152 - PR Interval, QRS Duration, QT Interval, QTcF Interval and RR Interval;To evaluate the safety and tolerability of AZD3152 - Pulse rate;To evaluate the safety and tolerability of AZD3152 - Respiratory rate;To evaluate the safety and tolerability of AZD3152 - SAEs, MAAEs, and AESIs;To evaluate the safety and tolerability of AZD3152 - Serum Clincal Chemistry - Alanine aminotransferase;To evaluate the safety and tolerability of AZD3152 - Serum Clincal Chemistry - Albumin;To evaluate the safety and tolerability of AZD3152 - Serum Clincal Chemistry - Aspartate aminotransferase;To evaluate the safety and tolerability of AZD3152 - Serum Clincal Chemistry - Blood urea nitrogen;To evaluate the safety and tolerability of AZD3152 - Serum Clincal Chemistry - Calcium;To evaluate the safety and tolerability of AZD3152 - Serum Clincal Chemistry - Conjugated bilirubin;To evaluate the safety and tolerability of AZD3152 - Serum Clincal Chemistry - C reactive protein;To evaluate the safety and tolerability of AZD3152 - Serum Clincal Chemistry - Creatine kinase;To evaluate the safety and tolerability of AZD3152 - Serum Clincal Chemistry - Creatinine and estimated glomerular filtration rate;To evaluate the safety and tolerability of AZD3152 - Serum Clincal Chemistry - Gamma glutamyl transpeptidase;To evaluate the safety and tolerability of AZD3152 - Serum Clincal Chemistry - Glucose;To evaluate the safety and tolerability of AZD3152 - Serum Clincal Chemistry - Phosphate;To evaluate the safety and tolerability of AZD3152 - Serum Clincal Chemistry - Potassium;To evaluate the safety and tolerability of AZD3152 - Serum Clincal Chemistry - Sodium;To evaluate the safety and tolerability of AZD3152 - Serum Clincal Chemistry - Total bilirubin;To evaluate the safety and tolerability of AZD3152 - Serum Clincal Chemistry - Troponin T and I;To evaluate the safety and tolerability of AZD3152 - Serum Clincal Chemistry - Unconjugated bilirubin;To evaluate the safety and tolerability of AZD3152 - Urinalysis - Blood;To evaluate the safety and tolerability of AZD3152 - Urinalysis - Glucose;To evaluate the safety and tolerability of AZD3152 - Urinalysis - Microscopy;To evaluate the safety and tolerability of AZD3152 - Urinalysis - Protein
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