* age below 18 years or above 60 years. * pregnancy, lactation. * any co-morbidities e.g. (dm, hypertension, asthma) * participants receiving immunosuppressive or chemotherapy drugs. * active malignancy * severe confirmed cases, fulfilling any of the following criteria: 1. respiratory rate more than 30/min. 2. blood oxygen saturation of less than 93%. 3. lung infiltrates \>50% of the lung fields or rapid progression within 24-48 hours. 4. participants need respiratory support e.g. high flow oxygen, non-invasive or invasive mechanical ventilation. * critical cases defined as: occurrence of respiratory failure requiring mechanical ventilation; presence of shock; other organ failure that requires monitoring and treatment in the icu

* age below 18 years or above 60 years. * pregnancy, lactation. * any co-morbidities e.g. (dm, hypertension, asthma) * participants receiving immunosuppressive or chemotherapy drugs. * active malignancy * severe confirmed cases, fulfilling any of the following criteria: 1. respiratory rate more than 30/min. 2. blood oxygen saturation of less than 93%. 3. lung infiltrates \>50% of the lung fields or rapid progression within 24-48 hours. 4. participants need respiratory support e.g. high flow oxygen, non-invasive or invasive mechanical ventilation. * critical cases defined as: occurrence of respiratory failure requiring mechanical ventilation; presence of shock; other organ failure that requires monitoring and treatment in the icu

age below 18 years or above 60 years. pregnancy, lactation. any co-morbidities e.g. (dm, hypertension, asthma) participants receiving immunosuppressive or chemotherapy drugs. active malignancy severe confirmed cases, fulfilling any of the following criteria: respiratory rate more than 30/min. blood oxygen saturation of less than 93%. lung infiltrates >50% of the lung fields or rapid progression within 24-48 hours. participants need respiratory support e.g. high flow oxygen, non-invasive or invasive mechanical ventilation. critical cases defined as: occurrence of respiratory failure requiring mechanical ventilation; presence of shock; other organ failure that requires monitoring and treatment in the icu

age below 18 years or above 60 years. pregnancy, lactation. any co-morbidities e.g. (dm, hypertension, asthma) participants receiving immunosuppressive or chemotherapy drugs. active malignancy severe confirmed cases, fulfilling any of the following criteria: respiratory rate more than 30/min. blood oxygen saturation of less than 93%. lung infiltrates >50% of the lung fields or rapid progression within 24-48 hours. participants need respiratory support e.g. high flow oxygen, non-invasive or invasive mechanical ventilation. critical cases defined as: occurrence of respiratory failure requiring mechanical ventilation; presence of shock; other organ failure that requires monitoring and treatment in the icu

age below 18 years or above 60 years. pregnancy, lactation. any co-morbidities e.g. (dm, hypertension, asthma) patients receiving immunosuppressive or chemotherapy drugs. active malignancy severe confirmed cases, fulfilling any of the following criteria: respiratory rate more than 30/min. blood oxygen saturation of less than 93%. lung infiltrates >50% of the lung fields or rapid progression within 24-48 hours. patients need respiratory support e.g. high flow oxygen, non-invasive or invasive mechanical ventilation. critical cases defined as: occurrence of respiratory failure requiring mechanical ventilation; presence of shock; other organ failure that requires monitoring and treatment in the icu

age below 18 years or above 60 years. pregnancy, lactation. any co-morbidities e.g. (dm, hypertension, asthma) patients receiving immunosuppressive or chemotherapy drugs. active malignancy severe confirmed cases, fulfilling any of the following criteria: respiratory rate more than 30/min. blood oxygen saturation of less than 93%. lung infiltrates >50% of the lung fields or rapid progression within 24-48 hours. patients need respiratory support e.g. high flow oxygen, non-invasive or invasive mechanical ventilation. critical cases defined as: occurrence of respiratory failure requiring mechanical ventilation; presence of shock; other organ failure that requires monitoring and treatment in the icu