inclusion criteria: 1. adults aged 18 years and older, body mass index (bmi) is between 18-30, able to provide legal proof of identity 2. participants voluntarily agreed to participate in the study and signed an informed consent form 3. the subject has ability to understand the research process and is willing and able to comply with all research proposals and other requirements of the study 4. axillary temperature ≤37.3°c on the day of injection 5. negative sars-cov-2 reverse transcription-polymerase chain reaction (rt-pcr) test, without infective history of severe acute respiratory syndrome (sars), coronavirus disease 2019 (covid-19), middle east respiratory syndrome (mers) 6. female subjects of childbearing age are not at pregnant period (negative result of pregnancy test) or lactation period 7. female subjects of childbearing age had taken effective contraceptive measures 1 month before enrollment 8. female subjects of childbearing age and male subjects agree to use effective contraception for 12 months from the screening visit to the full injection 9. female subjects of childbearing age and male subjects agree that do not donate eggs (eggs, oocytes) for assisted reproduction (female subjects of childbearing age) or avoid sperm donation (male subjects) from screening period until 12 months after injection

inclusion criteria: 1. adults aged 18 years and older, body mass index (bmi) is between 18-30, able to provide legal proof of identity 2. participants voluntarily agreed to participate in the study and signed an informed consent form 3. the subject has ability to understand the research process and is willing and able to comply with all research proposals and other requirements of the study 4. axillary temperature ≤37.3°c on the day of injection 5. negative sars-cov-2 reverse transcription-polymerase chain reaction (rt-pcr) test, without infective history of severe acute respiratory syndrome (sars), coronavirus disease 2019 (covid-19), middle east respiratory syndrome (mers) 6. female subjects of childbearing age are not at pregnant period (negative result of pregnancy test) or lactation period 7. female subjects of childbearing age had taken effective contraceptive measures 1 month before enrollment 8. female subjects of childbearing age and male subjects agree to use effective contraception for 12 months from the screening visit to the full injection 9. female subjects of childbearing age and male subjects agree that do not donate eggs (eggs, oocytes) for assisted reproduction (female subjects of childbearing age) or avoid sperm donation (male subjects) from screening period until 12 months after injection

inclusion criteria: adults aged 18 years and older, body mass index (bmi) is between 18-30, able to provide legal proof of identity participants voluntarily agreed to participate in the study and signed an informed consent form the subject has ability to understand the research process and is willing and able to comply with all research proposals and other requirements of the study axillary temperature ≤37.3°c on the day of injection negative sars-cov-2 reverse transcription-polymerase chain reaction (rt-pcr) test, without infective history of severe acute respiratory syndrome (sars), coronavirus disease 2019 (covid-19), middle east respiratory syndrome (mers) female subjects of childbearing age are not at pregnant period (negative result of pregnancy test) or lactation period female subjects of childbearing age had taken effective contraceptive measures 1 month before enrollment female subjects of childbearing age and male subjects agree to use effective contraception for 12 months from the screening visit to the full injection female subjects of childbearing age and male subjects agree that do not donate eggs (eggs, oocytes) for assisted reproduction (female subjects of childbearing age) or avoid sperm donation (male subjects) from screening period until 12 months after injection

inclusion criteria: adults aged 18 years and older, body mass index (bmi) is between 18-30, able to provide legal proof of identity participants voluntarily agreed to participate in the study and signed an informed consent form the subject has ability to understand the research process and is willing and able to comply with all research proposals and other requirements of the study axillary temperature ≤37.3°c on the day of injection negative sars-cov-2 reverse transcription-polymerase chain reaction (rt-pcr) test, without infective history of severe acute respiratory syndrome (sars), coronavirus disease 2019 (covid-19), middle east respiratory syndrome (mers) female subjects of childbearing age are not at pregnant period (negative result of pregnancy test) or lactation period female subjects of childbearing age had taken effective contraceptive measures 1 month before enrollment female subjects of childbearing age and male subjects agree to use effective contraception for 12 months from the screening visit to the full injection female subjects of childbearing age and male subjects agree that do not donate eggs (eggs, oocytes) for assisted reproduction (female subjects of childbearing age) or avoid sperm donation (male subjects) from screening period until 12 months after injection