1. history of allergic disease or reactions likely to be exacerbated by any component of azd1222. 2. active infection with sars-cov-2 as confirmed by rt-pcr. 3. known past laboratory-confirmed sars-cov-2 infection. note: participant's baseline serostatus determined as part of the study will not be used as a basis for exclusion from the study. 4. significant infection or other acute illness, including fever \> 37.8°c on the day prior to or day of first dosing. 5. any confirmed or suspected immunosuppressive or immunodeficient state, including hiv infection; asplenia; recurrent severe infections and use of immunosuppressant medication within the past 6 months (≥ 20 mg/kg/day of prednisone or its equivalent, given daily or on alternate days for ≥ 15 days within 30 days prior to administration of study intervention), except topical/inhaled steroids or short-term oral steroids (course lasting ≤ 14 days). 1. note: hiv-positive participants with cd4 counts \> 500 for ≥ 12 months and on a stable hiv antiretroviral regimen may be enrolled 2. note: topical tacrolimus is allowed if not used within 14 days prior to the day of erolment. 6. history of primary malignancy except for: 1. malignancy with low potential risk for recurrence after curative treatment (for example, history of childhood leukaemia) or metastasis (for example, indolent prostate cancer) in the opinion of the site investigator. 2. adequately treated non-melanoma skin cancer or lentigo maligna without evidence of disease 3. adequately treated uterine cervical carcinoma in situ without evidence of disease 4. localised prostate cancer 7. clinically significant bleeding disorder (eg, factor deficiency, coagulopathy, or platelet disorder), or prior history of significant bleeding or bruising following im injections or venepuncture. 8. severe and/or uncontrolled cardiovascular disease, respiratory disease, gastrointestinal disease, liver disease, renal disease, endocrine disorder, and neurological illness, as judged by the investigator (mild/moderate well-controlled comorbidities are allowed). 9. history of guillain-barré syndrome, or other neuroimmunological disease. 10. any other significant disease, disorder, or finding that may significantly increase the risk to the participant, affect the ability of the participant to participate in the study, or impair interpretation of the study data. 11. receipt of, or planned receipt of investigational products indicated for the treatment or prevention of sars-cov-2 or covid-19. note: for participants in the study who become hospitalised with covid-19, receipt of licensed treatment options and/or participation in investigational treatment studies is permitted. 12. receipt of any vaccine (licensed or investigational) other than licensed influenza vaccines within 30 days prior to and after administration of study intervention. 13. receipt of any influenza vaccine (licensed or investigational) within 7 days prior to and after administration of study intervention. 14. receipt of immunoglobulins and/or any blood products within 3 months prior to administration of study intervention or expected receipt during the period of study follow-up. 15. involvement in the planning and/or conduct of the study (applies to both sponsor staff and/or staff at the study site). 16. for women only - currently pregnant (confirmed with positive pregnancy test) or breastfeeding 17. judgment by the investigator that the participant should not participate in the study if the participant is unlikely to comply with study procedures, restrictions, and requirements. 18. previous enrolment in the present study. 5.3 lifestyle considerations 1) participants must follow the contraception requirements 2) restrictions relating to concomitant medications

1. history of allergic disease or reactions likely to be exacerbated by any component of azd1222. 2. active infection with sars-cov-2 as confirmed by rt-pcr. 3. known past laboratory-confirmed sars-cov-2 infection. note: participant's baseline serostatus determined as part of the study will not be used as a basis for exclusion from the study. 4. significant infection or other acute illness, including fever \> 37.8°c on the day prior to or day of first dosing. 5. any confirmed or suspected immunosuppressive or immunodeficient state, including hiv infection; asplenia; recurrent severe infections and use of immunosuppressant medication within the past 6 months (≥ 20 mg/kg/day of prednisone or its equivalent, given daily or on alternate days for ≥ 15 days within 30 days prior to administration of study intervention), except topical/inhaled steroids or short-term oral steroids (course lasting ≤ 14 days). 1. note: hiv-positive participants with cd4 counts \> 500 for ≥ 12 months and on a stable hiv antiretroviral regimen may be enrolled 2. note: topical tacrolimus is allowed if not used within 14 days prior to the day of erolment. 6. history of primary malignancy except for: 1. malignancy with low potential risk for recurrence after curative treatment (for example, history of childhood leukaemia) or metastasis (for example, indolent prostate cancer) in the opinion of the site investigator. 2. adequately treated non-melanoma skin cancer or lentigo maligna without evidence of disease 3. adequately treated uterine cervical carcinoma in situ without evidence of disease 4. localised prostate cancer 7. clinically significant bleeding disorder (eg, factor deficiency, coagulopathy, or platelet disorder), or prior history of significant bleeding or bruising following im injections or venepuncture. 8. severe and/or uncontrolled cardiovascular disease, respiratory disease, gastrointestinal disease, liver disease, renal disease, endocrine disorder, and neurological illness, as judged by the investigator (mild/moderate well-controlled comorbidities are allowed). 9. history of guillain-barré syndrome, or other neuroimmunological disease. 10. any other significant disease, disorder, or finding that may significantly increase the risk to the participant, affect the ability of the participant to participate in the study, or impair interpretation of the study data. 11. receipt of, or planned receipt of investigational products indicated for the treatment or prevention of sars-cov-2 or covid-19. note: for participants in the study who become hospitalised with covid-19, receipt of licensed treatment options and/or participation in investigational treatment studies is permitted. 12. receipt of any vaccine (licensed or investigational) other than licensed influenza vaccines within 30 days prior to and after administration of study intervention. 13. receipt of any influenza vaccine (licensed or investigational) within 7 days prior to and after administration of study intervention. 14. receipt of immunoglobulins and/or any blood products within 3 months prior to administration of study intervention or expected receipt during the period of study follow-up. 15. involvement in the planning and/or conduct of the study (applies to both sponsor staff and/or staff at the study site). 16. for women only - currently pregnant (confirmed with positive pregnancy test) or breastfeeding 17. judgment by the investigator that the participant should not participate in the study if the participant is unlikely to comply with study procedures, restrictions, and requirements. 18. previous enrolment in the present study. 5.3 lifestyle considerations 1) participants must follow the contraception requirements 2) restrictions relating to concomitant medications

history of allergic disease or reactions likely to be exacerbated by any component of azd1222. active infection with sars-cov-2 as confirmed by rt-pcr. known past laboratory-confirmed sars-cov-2 infection. note: participant's baseline serostatus determined as part of the study will not be used as a basis for exclusion from the study. significant infection or other acute illness, including fever > 37.8°c on the day prior to or day of first dosing. any confirmed or suspected immunosuppressive or immunodeficient state, including hiv infection; asplenia; recurrent severe infections and use of immunosuppressant medication within the past 6 months (≥ 20 mg/kg/day of prednisone or its equivalent, given daily or on alternate days for ≥ 15 days within 30 days prior to administration of study intervention), except topical/inhaled steroids or short-term oral steroids (course lasting ≤ 14 days). note: hiv-positive participants with cd4 counts > 500 for ≥ 12 months and on a stable hiv antiretroviral regimen may be enrolled note: topical tacrolimus is allowed if not used within 14 days prior to the day of erolment. history of primary malignancy except for: malignancy with low potential risk for recurrence after curative treatment (for example, history of childhood leukaemia) or metastasis (for example, indolent prostate cancer) in the opinion of the site investigator. adequately treated non-melanoma skin cancer or lentigo maligna without evidence of disease adequately treated uterine cervical carcinoma in situ without evidence of disease localised prostate cancer clinically significant bleeding disorder (eg, factor deficiency, coagulopathy, or platelet disorder), or prior history of significant bleeding or bruising following im injections or venepuncture. severe and/or uncontrolled cardiovascular disease, respiratory disease, gastrointestinal disease, liver disease, renal disease, endocrine disorder, and neurological illness, as judged by the investigator (mild/moderate well-controlled comorbidities are allowed). history of guillain-barré syndrome, or other neuroimmunological disease. any other significant disease, disorder, or finding that may significantly increase the risk to the participant, affect the ability of the participant to participate in the study, or impair interpretation of the study data. receipt of, or planned receipt of investigational products indicated for the treatment or prevention of sars-cov-2 or covid-19. note: for participants in the study who become hospitalised with covid-19, receipt of licensed treatment options and/or participation in investigational treatment studies is permitted. receipt of any vaccine (licensed or investigational) other than licensed influenza vaccines within 30 days prior to and after administration of study intervention. receipt of any influenza vaccine (licensed or investigational) within 7 days prior to and after administration of study intervention. receipt of immunoglobulins and/or any blood products within 3 months prior to administration of study intervention or expected receipt during the period of study follow-up. involvement in the planning and/or conduct of the study (applies to both sponsor staff and/or staff at the study site). for women only - currently pregnant (confirmed with positive pregnancy test) or breastfeeding judgment by the investigator that the participant should not participate in the study if the participant is unlikely to comply with study procedures, restrictions, and requirements. previous enrolment in the present study. 5.3 lifestyle considerations 1) participants must follow the contraception requirements 2) restrictions relating to concomitant medications

history of allergic disease or reactions likely to be exacerbated by any component of azd1222. active infection with sars-cov-2 as confirmed by rt-pcr. known past laboratory-confirmed sars-cov-2 infection. note: participant's baseline serostatus determined as part of the study will not be used as a basis for exclusion from the study. significant infection or other acute illness, including fever > 37.8°c on the day prior to or day of first dosing. any confirmed or suspected immunosuppressive or immunodeficient state, including hiv infection; asplenia; recurrent severe infections and use of immunosuppressant medication within the past 6 months (≥ 20 mg/kg/day of prednisone or its equivalent, given daily or on alternate days for ≥ 15 days within 30 days prior to administration of study intervention), except topical/inhaled steroids or short-term oral steroids (course lasting ≤ 14 days). note: hiv-positive participants with cd4 counts > 500 for ≥ 12 months and on a stable hiv antiretroviral regimen may be enrolled note: topical tacrolimus is allowed if not used within 14 days prior to the day of erolment. history of primary malignancy except for: malignancy with low potential risk for recurrence after curative treatment (for example, history of childhood leukaemia) or metastasis (for example, indolent prostate cancer) in the opinion of the site investigator. adequately treated non-melanoma skin cancer or lentigo maligna without evidence of disease adequately treated uterine cervical carcinoma in situ without evidence of disease localised prostate cancer clinically significant bleeding disorder (eg, factor deficiency, coagulopathy, or platelet disorder), or prior history of significant bleeding or bruising following im injections or venepuncture. severe and/or uncontrolled cardiovascular disease, respiratory disease, gastrointestinal disease, liver disease, renal disease, endocrine disorder, and neurological illness, as judged by the investigator (mild/moderate well-controlled comorbidities are allowed). history of guillain-barré syndrome, or other neuroimmunological disease. any other significant disease, disorder, or finding that may significantly increase the risk to the participant, affect the ability of the participant to participate in the study, or impair interpretation of the study data. receipt of, or planned receipt of investigational products indicated for the treatment or prevention of sars-cov-2 or covid-19. note: for participants in the study who become hospitalised with covid-19, receipt of licensed treatment options and/or participation in investigational treatment studies is permitted. receipt of any vaccine (licensed or investigational) other than licensed influenza vaccines within 30 days prior to and after administration of study intervention. receipt of any influenza vaccine (licensed or investigational) within 7 days prior to and after administration of study intervention. receipt of immunoglobulins and/or any blood products within 3 months prior to administration of study intervention or expected receipt during the period of study follow-up. involvement in the planning and/or conduct of the study (applies to both sponsor staff and/or staff at the study site). for women only - currently pregnant (confirmed with positive pregnancy test) or breastfeeding judgment by the investigator that the participant should not participate in the study if the participant is unlikely to comply with study procedures, restrictions, and requirements. previous enrolment in the present study. 5.3 lifestyle considerations 1) participants must follow the contraception requirements 2) restrictions relating to concomitant medications

1. history of allergic disease or reactions likely to be exacerbated by any component of azd1222. 2. active infection with sars-cov-2 as confirmed by rt-pcr. 3. known past laboratory-confirmed sars-cov-2 infection. note: participant's baseline serostatus determined as part of the study will not be used as a basis for exclusion from the study. 4. significant infection or other acute illness, including fever > 37.8°c on the day prior to or day of first dosing. 5. any confirmed or suspected immunosuppressive or immunodeficient state, including hiv infection; asplenia; recurrent severe infections and use of immunosuppressant medication within the past 6 months (≥ 20 mg/kg/day of prednisone or its equivalent, given daily or on alternate days for ≥ 15 days within 30 days prior to administration of study intervention), except topical/inhaled steroids or short-term oral steroids (course lasting ≤ 14 days). 1. note: hiv-positive participants with cd4 counts > 500 for ≥ 12 months and on a stable hiv antiretroviral regimen may be enrolled 2. note: topical tacrolimus is allowed if not used within 14 days prior to the day of erolment. 6. history of primary malignancy except for: 1. malignancy with low potential risk for recurrence after curative treatment (for example, history of childhood leukaemia) or metastasis (for example, indolent prostate cancer) in the opinion of the site investigator. 2. adequately treated non-melanoma skin cancer or lentigo maligna without evidence of disease 3. adequately treated uterine cervical carcinoma in situ without evidence of disease 4. localised prostate cancer 7. clinically significant bleeding disorder (eg, factor deficiency, coagulopathy, or platelet disorder), or prior history of significant bleeding or bruising following im injections or venepuncture. 8. severe and/or uncontrolled cardiovascular disease, respiratory disease, gastrointestinal disease, liver disease, renal disease, endocrine disorder, and neurological illness, as judged by the investigator (mild/moderate well-controlled comorbidities are allowed). 9. history of guillain-barré syndrome, or other neuroimmunological disease. 10. any other significant disease, disorder, or finding that may significantly increase the risk to the participant, affect the ability of the participant to participate in the study, or impair interpretation of the study data. 11. receipt of, or planned receipt of investigational products indicated for the treatment or prevention of sars-cov-2 or covid-19. note: for participants in the study who become hospitalised with covid-19, receipt of licensed treatment options and/or participation in investigational treatment studies is permitted. 12. receipt of any vaccine (licensed or investigational) other than licensed influenza vaccines within 30 days prior to and after administration of study intervention. 13. receipt of any influenza vaccine (licensed or investigational) within 7 days prior to and after administration of study intervention. 14. receipt of immunoglobulins and/or any blood products within 3 months prior to administration of study intervention or expected receipt during the period of study follow-up. 15. involvement in the planning and/or conduct of the study (applies to both sponsor staff and/or staff at the study site). 16. for women only - currently pregnant (confirmed with positive pregnancy test) or breastfeeding 17. judgment by the investigator that the participant should not participate in the study if the participant is unlikely to comply with study procedures, restrictions, and requirements. 18. previous enrolment in the present study. 5.3 lifestyle considerations 1) participants must follow the contraception requirements 2) restrictions relating to concomitant medications

1. history of allergic disease or reactions likely to be exacerbated by any component of azd1222. 2. active infection with sars-cov-2 as confirmed by rt-pcr. 3. known past laboratory-confirmed sars-cov-2 infection. note: participant's baseline serostatus determined as part of the study will not be used as a basis for exclusion from the study. 4. significant infection or other acute illness, including fever > 37.8°c on the day prior to or day of first dosing. 5. any confirmed or suspected immunosuppressive or immunodeficient state, including hiv infection; asplenia; recurrent severe infections and use of immunosuppressant medication within the past 6 months (≥ 20 mg/kg/day of prednisone or its equivalent, given daily or on alternate days for ≥ 15 days within 30 days prior to administration of study intervention), except topical/inhaled steroids or short-term oral steroids (course lasting ≤ 14 days). 1. note: hiv-positive participants with cd4 counts > 500 for ≥ 12 months and on a stable hiv antiretroviral regimen may be enrolled 2. note: topical tacrolimus is allowed if not used within 14 days prior to the day of erolment. 6. history of primary malignancy except for: 1. malignancy with low potential risk for recurrence after curative treatment (for example, history of childhood leukaemia) or metastasis (for example, indolent prostate cancer) in the opinion of the site investigator. 2. adequately treated non-melanoma skin cancer or lentigo maligna without evidence of disease 3. adequately treated uterine cervical carcinoma in situ without evidence of disease 4. localised prostate cancer 7. clinically significant bleeding disorder (eg, factor deficiency, coagulopathy, or platelet disorder), or prior history of significant bleeding or bruising following im injections or venepuncture. 8. severe and/or uncontrolled cardiovascular disease, respiratory disease, gastrointestinal disease, liver disease, renal disease, endocrine disorder, and neurological illness, as judged by the investigator (mild/moderate well-controlled comorbidities are allowed). 9. history of guillain-barré syndrome, or other neuroimmunological disease. 10. any other significant disease, disorder, or finding that may significantly increase the risk to the participant, affect the ability of the participant to participate in the study, or impair interpretation of the study data. 11. receipt of, or planned receipt of investigational products indicated for the treatment or prevention of sars-cov-2 or covid-19. note: for participants in the study who become hospitalised with covid-19, receipt of licensed treatment options and/or participation in investigational treatment studies is permitted. 12. receipt of any vaccine (licensed or investigational) other than licensed influenza vaccines within 30 days prior to and after administration of study intervention. 13. receipt of any influenza vaccine (licensed or investigational) within 7 days prior to and after administration of study intervention. 14. receipt of immunoglobulins and/or any blood products within 3 months prior to administration of study intervention or expected receipt during the period of study follow-up. 15. involvement in the planning and/or conduct of the study (applies to both sponsor staff and/or staff at the study site). 16. for women only - currently pregnant (confirmed with positive pregnancy test) or breastfeeding 17. judgment by the investigator that the participant should not participate in the study if the participant is unlikely to comply with study procedures, restrictions, and requirements. 18. previous enrolment in the present study. 5.3 lifestyle considerations 1) participants must follow the contraception requirements 2) restrictions relating to concomitant medications