an individual who meets any of the following criteria will be excluded from participation in this study: 1. respiratory failure requiring mechanical ventilation, non-invasive ventilation including continuous positive airway pressure (cpap) (for an indication other than previously diagnosed sleep apnea and maintained on outpatient settings), or extra-corporeal membrane oxygenation or anticipated to require any of those treatments or to die within 24 hours. 2. anticipated discharge from the hospital or transfer to another hospital that is not a study site within 72 hours. 3. history of previous transfusion reaction. 4. previously documented serum immunoglobulin a (iga) deficiency (\<7 mg/dl) 5. documented to have received convalescent plasma in the last 60 days.

an individual who meets any of the following criteria will be excluded from participation in this study: 1. respiratory failure requiring mechanical ventilation, non-invasive ventilation including continuous positive airway pressure (cpap) (for an indication other than previously diagnosed sleep apnea and maintained on outpatient settings), or extra-corporeal membrane oxygenation or anticipated to require any of those treatments or to die within 24 hours. 2. anticipated discharge from the hospital or transfer to another hospital that is not a study site within 72 hours. 3. history of previous transfusion reaction. 4. previously documented serum immunoglobulin a (iga) deficiency (\<7 mg/dl) 5. documented to have received convalescent plasma in the last 60 days.

an individual who meets any of the following criteria will be excluded from participation in this study: respiratory failure requiring mechanical ventilation, non-invasive ventilation including continuous positive airway pressure (cpap) (for an indication other than previously diagnosed sleep apnea and maintained on outpatient settings), or extra-corporeal membrane oxygenation or anticipated to require any of those treatments or to die within 24 hours. anticipated discharge from the hospital or transfer to another hospital that is not a study site within 72 hours. history of previous transfusion reaction. previously documented serum immunoglobulin a (iga) deficiency (<7 mg/dl) documented to have received convalescent plasma in the last 60 days.

an individual who meets any of the following criteria will be excluded from participation in this study: respiratory failure requiring mechanical ventilation, non-invasive ventilation including continuous positive airway pressure (cpap) (for an indication other than previously diagnosed sleep apnea and maintained on outpatient settings), or extra-corporeal membrane oxygenation or anticipated to require any of those treatments or to die within 24 hours. anticipated discharge from the hospital or transfer to another hospital that is not a study site within 72 hours. history of previous transfusion reaction. previously documented serum immunoglobulin a (iga) deficiency (<7 mg/dl) documented to have received convalescent plasma in the last 60 days.

an individual who meets any of the following criteria will be excluded from participation in this study: respiratory failure requiring mechanical ventilation, non-invasive ventilation including cpap (for an indication other than previously diagnosed sleep apnea and maintained on outpatient settings), or extra-corporeal membrane oxygenation or anticipated to require any of those treatments or to die within 24 hours. anticipated discharge from the hospital or transfer to another hospital that is not a study site within 72 hours. history of previous transfusion reaction. previously documented serum iga deficiency (<7 mg/dl) documented to have received convalescent plasma in the last 60 days.

an individual who meets any of the following criteria will be excluded from participation in this study: respiratory failure requiring mechanical ventilation, non-invasive ventilation including cpap (for an indication other than previously diagnosed sleep apnea and maintained on outpatient settings), or extra-corporeal membrane oxygenation or anticipated to require any of those treatments or to die within 24 hours. anticipated discharge from the hospital or transfer to another hospital that is not a study site within 72 hours. history of previous transfusion reaction. previously documented serum iga deficiency (<7 mg/dl) documented to have received convalescent plasma in the last 60 days.

an individual who meets any of the following criteria will be excluded from participation in this study: 1. respiratory failure requiring mechanical ventilation, non-invasive ventilation including cpap (for an indication other than previously diagnosed sleep apnea and maintained on outpatient settings), or extra-corporeal membrane oxygenation or anticipated to require any of those treatments or to die within 24 hours. 2. anticipated discharge from the hospital or transfer to another hospital that is not a study site within 72 hours. 3. history of previous transfusion reaction. 4. previously documented serum iga deficiency (<7 mg/dl) 5. documented to have received convalescent plasma in the last 60 days.

an individual who meets any of the following criteria will be excluded from participation in this study: 1. respiratory failure requiring mechanical ventilation, non-invasive ventilation including cpap (for an indication other than previously diagnosed sleep apnea and maintained on outpatient settings), or extra-corporeal membrane oxygenation or anticipated to require any of those treatments or to die within 24 hours. 2. anticipated discharge from the hospital or transfer to another hospital that is not a study site within 72 hours. 3. history of previous transfusion reaction. 4. previously documented serum iga deficiency (<7 mg/dl) 5. documented to have received convalescent plasma in the last 60 days.