inclusion criteria: * a patient, or legal authorized representative (lar), has provided informed consent and a written informed consent form. * positive covid-19 test. * must be receiving medical care in an intensive care nursing situation. * respiratory failure due to covid-19 disease requiring invasive mechanical ventilation. this care may include but is not required to include the use of dexamethasone. * within 18 hours of tracheal intubation to support invasive mechanical ventilation. a goal of this study is that t0 will occur within 24 hours of tracheal intubation to support invasive mechanical ventilation. * age 18 to 80 years. * males and females (females of childbearing potential who are not pregnant confirmed by a negative serum pregnancy test) and not lactating if recently post-partum). * intent to deliver full supportive care through aggressive management utilizing all available therapies for a minimum of 96 hours.

inclusion criteria: * a patient, or legal authorized representative (lar), has provided informed consent and a written informed consent form. * positive covid-19 test. * must be receiving medical care in an intensive care nursing situation. * respiratory failure due to covid-19 disease requiring invasive mechanical ventilation. this care may include but is not required to include the use of dexamethasone. * within 18 hours of tracheal intubation to support invasive mechanical ventilation. a goal of this study is that t0 will occur within 24 hours of tracheal intubation to support invasive mechanical ventilation. * age 18 to 80 years. * males and females (females of childbearing potential who are not pregnant confirmed by a negative serum pregnancy test) and not lactating if recently post-partum). * intent to deliver full supportive care through aggressive management utilizing all available therapies for a minimum of 96 hours.

inclusion criteria: - a patient, or legal authorized representative (lar), has provided informed consent and a written informed consent form. - positive covid-19 test. - must be receiving medical care in an intensive care nursing situation. - respiratory failure due to covid-19 disease requiring invasive mechanical ventilation. this care may include but is not required to include the use of dexamethasone. - within 18 hours of tracheal intubation to support invasive mechanical ventilation. a goal of this study is that t0 will occur within 24 hours of tracheal intubation to support invasive mechanical ventilation. - age 18 to 80 years. - males and females (females of childbearing potential who are not pregnant confirmed by a negative serum pregnancy test) and not lactating if recently post-partum). - intent to deliver full supportive care through aggressive management utilizing all available therapies for a minimum of 96 hours.

inclusion criteria: - a patient, or legal authorized representative (lar), has provided informed consent and a written informed consent form. - positive covid-19 test. - must be receiving medical care in an intensive care nursing situation. - respiratory failure due to covid-19 disease requiring invasive mechanical ventilation. this care may include but is not required to include the use of dexamethasone. - within 18 hours of tracheal intubation to support invasive mechanical ventilation. a goal of this study is that t0 will occur within 24 hours of tracheal intubation to support invasive mechanical ventilation. - age 18 to 80 years. - males and females (females of childbearing potential who are not pregnant confirmed by a negative serum pregnancy test) and not lactating if recently post-partum). - intent to deliver full supportive care through aggressive management utilizing all available therapies for a minimum of 96 hours.