* received any covid-19 vaccine other than bnt162b2, bbibp-corv, or coronavac. * received more than 3 doses of bnt162b2 or more than 4 doses of bbibp-corv or coronavac. * women who are pregnant or breastfeeding or intending to become pregnant; mend who will father children within the projected duration of the trial. * positive serology test results for hepatitis c virus antibody, human immunodeficiency virus antibody, or hepatitis b viral surface antigen at screening. * is currently participating in or has participated in a study with an investigational product within 30 days preceding day 1. * history of severe allergic reactions (eg, acute anaphylaxis, urticaria, skin eczema, dyspnoea, angioneurotic oedema) or other significant adverse reactions to covid19 vaccines; allergy to known composition of rvm-001 and rvm-002. * history of coagulation dysfunction (eg, coagulation factor deficiency, coagulation disease). * vaccinated with live attenuated vaccine within 1 month, or any other vaccine within 14 days, of day 1 vaccination. * received systemic immunosuppressants within 4 months prior to vaccination or an anticipated need for immunosuppressants at any time during the study. topical or inhaled treatment is allowed if not used within 14 days prior to day 1 vaccination. * received blood products within 3 months prior to day 1 vaccination. * history of alcohol or drug abuse within 3 years prior to day 1 vaccination. * fever (temperature \> 37.5°c), dry cough, fatigue, nasal obstruction, runny nose, sore throat, myalgia, diarrhoea, shortness of breath, or dyspnoea on the day of vaccination. * any condition that, in the opinion of the investigator, would pose a health risk to the subject if enrolled, could interfere with the evaluation of the study vaccine, or interfere with interpretation of the study results (including neurologic or psychiatric conditions deemed likely to impair the quality of safety reporting).

* received any covid-19 vaccine other than bnt162b2, bbibp-corv, or coronavac. * received more than 3 doses of bnt162b2 or more than 4 doses of bbibp-corv or coronavac. * women who are pregnant or breastfeeding or intending to become pregnant; mend who will father children within the projected duration of the trial. * positive serology test results for hepatitis c virus antibody, human immunodeficiency virus antibody, or hepatitis b viral surface antigen at screening. * is currently participating in or has participated in a study with an investigational product within 30 days preceding day 1. * history of severe allergic reactions (eg, acute anaphylaxis, urticaria, skin eczema, dyspnoea, angioneurotic oedema) or other significant adverse reactions to covid19 vaccines; allergy to known composition of rvm-001 and rvm-002. * history of coagulation dysfunction (eg, coagulation factor deficiency, coagulation disease). * vaccinated with live attenuated vaccine within 1 month, or any other vaccine within 14 days, of day 1 vaccination. * received systemic immunosuppressants within 4 months prior to vaccination or an anticipated need for immunosuppressants at any time during the study. topical or inhaled treatment is allowed if not used within 14 days prior to day 1 vaccination. * received blood products within 3 months prior to day 1 vaccination. * history of alcohol or drug abuse within 3 years prior to day 1 vaccination. * fever (temperature \> 37.5°c), dry cough, fatigue, nasal obstruction, runny nose, sore throat, myalgia, diarrhoea, shortness of breath, or dyspnoea on the day of vaccination. * any condition that, in the opinion of the investigator, would pose a health risk to the subject if enrolled, could interfere with the evaluation of the study vaccine, or interfere with interpretation of the study results (including neurologic or psychiatric conditions deemed likely to impair the quality of safety reporting).

received any covid-19 vaccine other than bnt162b2, bbibp-corv, or coronavac. received more than 3 doses of bnt162b2 or more than 4 doses of bbibp-corv or coronavac. women who are pregnant or breastfeeding or intending to become pregnant; mend who will father children within the projected duration of the trial. positive serology test results for hepatitis c virus antibody, human immunodeficiency virus antibody, or hepatitis b viral surface antigen at screening. is currently participating in or has participated in a study with an investigational product within 30 days preceding day 1. history of severe allergic reactions (eg, acute anaphylaxis, urticaria, skin eczema, dyspnoea, angioneurotic oedema) or other significant adverse reactions to covid19 vaccines; allergy to known composition of rvm-001 and rvm-002. history of coagulation dysfunction (eg, coagulation factor deficiency, coagulation disease). vaccinated with live attenuated vaccine within 1 month, or any other vaccine within 14 days, of day 1 vaccination. received systemic immunosuppressants within 4 months prior to vaccination or an anticipated need for immunosuppressants at any time during the study. topical or inhaled treatment is allowed if not used within 14 days prior to day 1 vaccination. received blood products within 3 months prior to day 1 vaccination. history of alcohol or drug abuse within 3 years prior to day 1 vaccination. fever (temperature > 37.5°c), dry cough, fatigue, nasal obstruction, runny nose, sore throat, myalgia, diarrhoea, shortness of breath, or dyspnoea on the day of vaccination. any condition that, in the opinion of the investigator, would pose a health risk to the subject if enrolled, could interfere with the evaluation of the study vaccine, or interfere with interpretation of the study results (including neurologic or psychiatric conditions deemed likely to impair the quality of safety reporting).

received any covid-19 vaccine other than bnt162b2, bbibp-corv, or coronavac. received more than 3 doses of bnt162b2 or more than 4 doses of bbibp-corv or coronavac. women who are pregnant or breastfeeding or intending to become pregnant; mend who will father children within the projected duration of the trial. positive serology test results for hepatitis c virus antibody, human immunodeficiency virus antibody, or hepatitis b viral surface antigen at screening. is currently participating in or has participated in a study with an investigational product within 30 days preceding day 1. history of severe allergic reactions (eg, acute anaphylaxis, urticaria, skin eczema, dyspnoea, angioneurotic oedema) or other significant adverse reactions to covid19 vaccines; allergy to known composition of rvm-001 and rvm-002. history of coagulation dysfunction (eg, coagulation factor deficiency, coagulation disease). vaccinated with live attenuated vaccine within 1 month, or any other vaccine within 14 days, of day 1 vaccination. received systemic immunosuppressants within 4 months prior to vaccination or an anticipated need for immunosuppressants at any time during the study. topical or inhaled treatment is allowed if not used within 14 days prior to day 1 vaccination. received blood products within 3 months prior to day 1 vaccination. history of alcohol or drug abuse within 3 years prior to day 1 vaccination. fever (temperature > 37.5°c), dry cough, fatigue, nasal obstruction, runny nose, sore throat, myalgia, diarrhoea, shortness of breath, or dyspnoea on the day of vaccination. any condition that, in the opinion of the investigator, would pose a health risk to the subject if enrolled, could interfere with the evaluation of the study vaccine, or interfere with interpretation of the study results (including neurologic or psychiatric conditions deemed likely to impair the quality of safety reporting).