inclusion criteria: * laboratory confirmed infection with sars-cov-2 or typical radiological signs of sars-cov-2 infection * hospitalisation due to covid-19 * informed consent obtained, the patient understands and agrees to comply with the planned study procedures. if a potential patient is unconscious, the patient information sheet with the informed consent form can be signed by the legal representative, if he/she accompanies the patient. it can be signed by a concilium consisting of doctors (2), investigator and an independent witness in case the legal representative is not available. * ≥18 years of age * willingness to perform effective measures of contraception during the study. * signs of respiratory deterioration such as oxygen saturation ≤94% when breathing ambient air or \>3% drop in oxygen saturation in case of chronic obstructive lung disease or need for oxygen supplementation to achieve satisfactory blood oxygen saturation (spo2\>90% at room air) as well as the need for non-invasive ventilation, high-flow oxygen devices or mechanical ventilation or radiological or clinical signs of pneumonia.

inclusion criteria: * laboratory confirmed infection with sars-cov-2 or typical radiological signs of sars-cov-2 infection * hospitalisation due to covid-19 * informed consent obtained, the patient understands and agrees to comply with the planned study procedures. if a potential patient is unconscious, the patient information sheet with the informed consent form can be signed by the legal representative, if he/she accompanies the patient. it can be signed by a concilium consisting of doctors (2), investigator and an independent witness in case the legal representative is not available. * ≥18 years of age * willingness to perform effective measures of contraception during the study. * signs of respiratory deterioration such as oxygen saturation ≤94% when breathing ambient air or \>3% drop in oxygen saturation in case of chronic obstructive lung disease or need for oxygen supplementation to achieve satisfactory blood oxygen saturation (spo2\>90% at room air) as well as the need for non-invasive ventilation, high-flow oxygen devices or mechanical ventilation or radiological or clinical signs of pneumonia.

inclusion criteria: - laboratory confirmed infection with sars-cov-2 or typical radiological signs of sars-cov-2 infection - hospitalisation due to covid-19 - informed consent obtained, the patient understands and agrees to comply with the planned study procedures. if a potential patient is unconscious, the patient information sheet with the informed consent form can be signed by the legal representative, if he/she accompanies the patient. it can be signed by a concilium consisting of doctors (2), investigator and an independent witness in case the legal representative is not available. - ≥18 years of age - willingness to perform effective measures of contraception during the study. - signs of respiratory deterioration such as oxygen saturation ≤94% when breathing ambient air or >3% drop in oxygen saturation in case of chronic obstructive lung disease or need for oxygen supplementation to achieve satisfactory blood oxygen saturation (spo2>90% at room air) as well as the need for non-invasive ventilation, high-flow oxygen devices or mechanical ventilation or radiological or clinical signs of pneumonia.

inclusion criteria: - laboratory confirmed infection with sars-cov-2 or typical radiological signs of sars-cov-2 infection - hospitalisation due to covid-19 - informed consent obtained, the patient understands and agrees to comply with the planned study procedures. if a potential patient is unconscious, the patient information sheet with the informed consent form can be signed by the legal representative, if he/she accompanies the patient. it can be signed by a concilium consisting of doctors (2), investigator and an independent witness in case the legal representative is not available. - ≥18 years of age - willingness to perform effective measures of contraception during the study. - signs of respiratory deterioration such as oxygen saturation ≤94% when breathing ambient air or >3% drop in oxygen saturation in case of chronic obstructive lung disease or need for oxygen supplementation to achieve satisfactory blood oxygen saturation (spo2>90% at room air) as well as the need for non-invasive ventilation, high-flow oxygen devices or mechanical ventilation or radiological or clinical signs of pneumonia.

inclusion criteria: - laboratory confirmed infection with sars-cov-2 (ideally but not necessarily ≤72 hours before randomisation) or typical radiological signs of sars-cov-2 infection - hospitalisation due to covid-19 - informed consent obtained, the patient understands and agrees to comply with the planned study procedures. if a potential patient is unconscious, the patient information sheet with the informed consent form can be signed by the legal representative, if he/she accompanies the patient. it can be signed by a concilium consisting of doctors (2), investigator and an independent witness in case the legal representative is not available. - ≥18 years of age - willingness to perform effective measures of contraception during the study. - signs of respiratory deterioration such as oxygen saturation <94% when breathing ambient air or >3% drop in oxygen saturation in case of chronic obstructive lung disease or need for oxygen supplementation to achieve satisfactory blood oxygen saturation (spo2>90% at room air) as well as the need for non-invasive ventilation, high-flow oxygen devices or mechanical ventilation or radiological or clinical signs of pneumonia.

inclusion criteria: - laboratory confirmed infection with sars-cov-2 (ideally but not necessarily ≤72 hours before randomisation) or typical radiological signs of sars-cov-2 infection - hospitalisation due to covid-19 - informed consent obtained, the patient understands and agrees to comply with the planned study procedures. if a potential patient is unconscious, the patient information sheet with the informed consent form can be signed by the legal representative, if he/she accompanies the patient. it can be signed by a concilium consisting of doctors (2), investigator and an independent witness in case the legal representative is not available. - ≥18 years of age - willingness to perform effective measures of contraception during the study. - signs of respiratory deterioration such as oxygen saturation <94% when breathing ambient air or >3% drop in oxygen saturation in case of chronic obstructive lung disease or need for oxygen supplementation to achieve satisfactory blood oxygen saturation (spo2>90% at room air) as well as the need for non-invasive ventilation, high-flow oxygen devices or mechanical ventilation or radiological or clinical signs of pneumonia.