1. evidence of critical illness, defined by at least one of the following: respiratory failure, multi-organ dysfunction/failure, cardiac failure or septic shock 2. participants that are anticipated by the study investigator to progress to critical disease, including mechanical ventilation, within 24 hours of enrolment 3. participants with pre-existing moderate to severe cardiovascular disease, uncontrolled diabetes, or severe asthma or severe copd. 3.participants with a known medical history of recent acute or chronic liver disease (other than nash), chronic or active hepatitis b or c infection, or primary biliary cirrhosis. 4.participants with a known medical history of ischemic heart disease, heart failure, dysrhythmia or other pre-existing cardiac condition. 5. participants with known hiv infection, acute or chronic history of hepatitis b or c. 6.participants with a known medical history of recurrent seizures. 7. participants with history of venous thromboembolic event, including deep venous thrombosis or pulmonary embolism 8.confirmed concurrent active systemic infection other than covid-19. 9.current diagnosis of cancer, unless in remission and untreated. 10.other medical or psychiatric condition including recent or active suicidal ideation/behavior or laboratory abnormality that may increase the risk of study participation 11.females who are pregnant or breastfeeding.

1. evidence of critical illness, defined by at least one of the following: respiratory failure, multi-organ dysfunction/failure, cardiac failure or septic shock 2. participants that are anticipated by the study investigator to progress to critical disease, including mechanical ventilation, within 24 hours of enrolment 3. participants with pre-existing moderate to severe cardiovascular disease, uncontrolled diabetes, or severe asthma or severe copd. 3.participants with a known medical history of recent acute or chronic liver disease (other than nash), chronic or active hepatitis b or c infection, or primary biliary cirrhosis. 4.participants with a known medical history of ischemic heart disease, heart failure, dysrhythmia or other pre-existing cardiac condition. 5. participants with known hiv infection, acute or chronic history of hepatitis b or c. 6.participants with a known medical history of recurrent seizures. 7. participants with history of venous thromboembolic event, including deep venous thrombosis or pulmonary embolism 8.confirmed concurrent active systemic infection other than covid-19. 9.current diagnosis of cancer, unless in remission and untreated. 10.other medical or psychiatric condition including recent or active suicidal ideation/behavior or laboratory abnormality that may increase the risk of study participation 11.females who are pregnant or breastfeeding.

evidence of critical illness, defined by at least one of the following: respiratory failure, multi-organ dysfunction/failure, cardiac failure or septic shock participants that are anticipated by the study investigator to progress to critical disease, including mechanical ventilation, within 24 hours of enrolment participants with pre-existing moderate to severe cardiovascular disease, uncontrolled diabetes, or severe asthma or severe copd. 3.participants with a known medical history of recent acute or chronic liver disease (other than nash), chronic or active hepatitis b or c infection, or primary biliary cirrhosis. 4.participants with a known medical history of ischemic heart disease, heart failure, dysrhythmia or other pre-existing cardiac condition. 5. participants with known hiv infection, acute or chronic history of hepatitis b or c. 6.participants with a known medical history of recurrent seizures. 7. participants with history of venous thromboembolic event, including deep venous thrombosis or pulmonary embolism 8.confirmed concurrent active systemic infection other than covid-19. 9.current diagnosis of cancer, unless in remission and untreated. 10.other medical or psychiatric condition including recent or active suicidal ideation/behavior or laboratory abnormality that may increase the risk of study participation 11.females who are pregnant or breastfeeding.

evidence of critical illness, defined by at least one of the following: respiratory failure, multi-organ dysfunction/failure, cardiac failure or septic shock participants that are anticipated by the study investigator to progress to critical disease, including mechanical ventilation, within 24 hours of enrolment participants with pre-existing moderate to severe cardiovascular disease, uncontrolled diabetes, or severe asthma or severe copd. 3.participants with a known medical history of recent acute or chronic liver disease (other than nash), chronic or active hepatitis b or c infection, or primary biliary cirrhosis. 4.participants with a known medical history of ischemic heart disease, heart failure, dysrhythmia or other pre-existing cardiac condition. 5. participants with known hiv infection, acute or chronic history of hepatitis b or c. 6.participants with a known medical history of recurrent seizures. 7. participants with history of venous thromboembolic event, including deep venous thrombosis or pulmonary embolism 8.confirmed concurrent active systemic infection other than covid-19. 9.current diagnosis of cancer, unless in remission and untreated. 10.other medical or psychiatric condition including recent or active suicidal ideation/behavior or laboratory abnormality that may increase the risk of study participation 11.females who are pregnant or breastfeeding.

1. evidence of critical illness, defined by at least one of the following: respiratory failure, multi-organ dysfunction/failure, cardiac failure or septic shock 2. participants that are anticipated by the study investigator to progress to critical disease, including mechanical ventilation, within 24 hours of enrolment 3. participants with pre-existing moderate to severe cardiovascular disease, uncontrolled diabetes, or severe asthma or severe copd. 3.participants with a known medical history of recent acute or chronic liver disease (other than nash), chronic or active hepatitis b or c infection, or primary biliary cirrhosis. 4.participants with a known medical history of ischemic heart disease, heart failure, dysrhythmia or other pre-existing cardiac condition. 5. participants with known hiv infection, acute or chronic history of hepatitis b or c. 6.participants with a known medical history of recurrent seizures. 7. participants with history of venous thromboembolic event, including deep venous thrombosis or pulmonary embolism 8.confirmed concurrent active systemic infection other than covid-19. 9.current diagnosis of cancer, unless in remission and untreated. 10.other medical or psychiatric condition including recent or active suicidal ideation/behavior or laboratory abnormality that may increase the risk of study participation 11.females who are pregnant or breastfeeding.

1. evidence of critical illness, defined by at least one of the following: respiratory failure, multi-organ dysfunction/failure, cardiac failure or septic shock 2. participants that are anticipated by the study investigator to progress to critical disease, including mechanical ventilation, within 24 hours of enrolment 3. participants with pre-existing moderate to severe cardiovascular disease, uncontrolled diabetes, or severe asthma or severe copd. 3.participants with a known medical history of recent acute or chronic liver disease (other than nash), chronic or active hepatitis b or c infection, or primary biliary cirrhosis. 4.participants with a known medical history of ischemic heart disease, heart failure, dysrhythmia or other pre-existing cardiac condition. 5. participants with known hiv infection, acute or chronic history of hepatitis b or c. 6.participants with a known medical history of recurrent seizures. 7. participants with history of venous thromboembolic event, including deep venous thrombosis or pulmonary embolism 8.confirmed concurrent active systemic infection other than covid-19. 9.current diagnosis of cancer, unless in remission and untreated. 10.other medical or psychiatric condition including recent or active suicidal ideation/behavior or laboratory abnormality that may increase the risk of study participation 11.females who are pregnant or breastfeeding.

1. evidence of critical illness, defined by at least one of the following: respiratory failure, multi-organ dysfunction/failure, cardiac failure or septic shock 2. participants with pre-existing moderate to severe cardiovascular disease, uncontrolled diabetes, or severe asthma or severe copd. 3. participants with a known medical history of recent acute or chronic liver disease (other than nash), chronic or active hepatitis b or c infection, or primary biliary cirrhosis. 4. participants with known hiv infection. 5. participants with a known medical history of ischemic heart disease, heart failure, dysrhythmia or other pre-existing cardiac condition. 6. participants with a known medical history of recurrent seizures. 7. confirmed concurrent active systemic infection other than covid-19. 8. current diagnosis of cancer, unless in remission and untreated. 9. other medical or psychiatric condition including recent or active suicidal ideation/behavior or laboratory abnormality that may increase the risk of study participation 10. previous administration with any investigational drug (including remdesivir, convalescent sera or monoclonal antibody treatment for covid-19 if not local standard of care) within 30 days.

1. evidence of critical illness, defined by at least one of the following: respiratory failure, multi-organ dysfunction/failure, cardiac failure or septic shock 2. participants with pre-existing moderate to severe cardiovascular disease, uncontrolled diabetes, or severe asthma or severe copd. 3. participants with a known medical history of recent acute or chronic liver disease (other than nash), chronic or active hepatitis b or c infection, or primary biliary cirrhosis. 4. participants with known hiv infection. 5. participants with a known medical history of ischemic heart disease, heart failure, dysrhythmia or other pre-existing cardiac condition. 6. participants with a known medical history of recurrent seizures. 7. confirmed concurrent active systemic infection other than covid-19. 8. current diagnosis of cancer, unless in remission and untreated. 9. other medical or psychiatric condition including recent or active suicidal ideation/behavior or laboratory abnormality that may increase the risk of study participation 10. previous administration with any investigational drug (including remdesivir, convalescent sera or monoclonal antibody treatment for covid-19 if not local standard of care) within 30 days.