* they do not authorize their participation * patients with contraindications to receiving treatment with corticosteroids * impossibility of understanding the requirements of the study, in the opinion of the researcher. * expected survival less than the duration of the study in the opinion of the investigator. * clinical evidence of active infection, including but not limited to bronchitis, pneumonia, sinusitis, urinary tract infection and / or cellulitis. * patient who receives a lung transplant during the study period. * impossibility of carrying out lung function studies. - poorly controlled diabetes mellitus (glycosylated hb\> 10%). * pregnancy or breastfeeding * they are participating in another intervention study

* they do not authorize their participation * patients with contraindications to receiving treatment with corticosteroids * impossibility of understanding the requirements of the study, in the opinion of the researcher. * expected survival less than the duration of the study in the opinion of the investigator. * clinical evidence of active infection, including but not limited to bronchitis, pneumonia, sinusitis, urinary tract infection and / or cellulitis. * patient who receives a lung transplant during the study period. * impossibility of carrying out lung function studies. - poorly controlled diabetes mellitus (glycosylated hb\> 10%). * pregnancy or breastfeeding * they are participating in another intervention study

- they do not authorize their participation - patients with contraindications to receiving treatment with corticosteroids - impossibility of understanding the requirements of the study, in the opinion of the researcher. - expected survival less than the duration of the study in the opinion of the investigator. - clinical evidence of active infection, including but not limited to bronchitis, pneumonia, sinusitis, urinary tract infection and / or cellulitis. - patient who receives a lung transplant during the study period. - impossibility of carrying out lung function studies. - poorly controlled diabetes mellitus (glycosylated hb> 10%). - pregnancy or breastfeeding - they are participating in another intervention study

- they do not authorize their participation - patients with contraindications to receiving treatment with corticosteroids - impossibility of understanding the requirements of the study, in the opinion of the researcher. - expected survival less than the duration of the study in the opinion of the investigator. - clinical evidence of active infection, including but not limited to bronchitis, pneumonia, sinusitis, urinary tract infection and / or cellulitis. - patient who receives a lung transplant during the study period. - impossibility of carrying out lung function studies. - poorly controlled diabetes mellitus (glycosylated hb> 10%). - pregnancy or breastfeeding - they are participating in another intervention study