* those who had fever (body temperature≥ 38.0 °c/100.4 °f), dry cough, fatigue, nasal congestion, runny nose, sore throat, myalgia, diarrhea, shortness of breath, and dyspnea in the past 14 days before vaccination; * subject whose sars-cov-2 nucleic acid test result is positive; * subject with a body temperature of ≥ 38.0 °c/100.4 °f (axillary temperature) on the day of enrollment; * subject who has oral ulcers, throat swelling and other oral and nasopharyngeal diseases; * subject with abnormal vital signs, physical examination and laboratory test indicators at screening that are judged by clinicians to be clinically significant; * subject who has a previous history of severe allergy to any drug, food or vaccination, such as urticaria, anaphylactic shock, allergic laryngeal edema, allergic dyspnea, skin eczema, henoch-schonlein purpura, thrombocytopenic purpura, local allergic necrosis reaction (arthus reaction), etc.; * subject who has suffered from acute disease or in the acute attack stage of chronic disease within 3 days before vaccination, or has used antipyretic, analgesic and anti-allergy drugs; * subject within 6 months prior to vaccination participation in a coronavirus (mers-cov, sars-cov-2) vaccine and/or drug (small molecule) and/or antibody study; participation in any clinical study within 3 months prior to vaccination or planned participation in other (drug or vaccine) clinical studies during the study; * subject who has received other vaccines within 1 month before vaccination; * subject who has used immunoenhancers or immunosuppressants in the past 3 months; * subject who was diagnosed with congenital or acquired immunodeficiency, or suspected to have systemic diseases that may interfere with the conduct or completion of the study, such as tuberculosis, hepatitis b, hepatitis c, human immunodeficiency virus (hiv), syphilis infection, etc.; * subject who was diagnosed with serious diseases, congenital anomalies or chronic disease that may interfere with the conduct or completion of the study (including but not limited to: allergy to vaccines, asthma and other respiratory diseases or chronic bronchitis, hypertension, hypotension, heart disease, kidney disease, diabetes mellitus (type 1 or type 2), autoimmune diseases, thalassemia, malignant tumor, atopy, existing skin diseases, etc.); * subject who has received blood or blood-related products (such as blood transfusion, use of human albumin, human immunoglobulin, etc.) within the past 6 months; * subject with a history or family history of convulsions, epilepsy, encephalopathy and psychosis; * subject with functional asplenia or splenectomy caused by any situation; * subject who has any condition that, in the opinion of the investigator, may interfere with the evaluation of the objectives of the study.

* those who had fever (body temperature≥ 38.0 °c/100.4 °f), dry cough, fatigue, nasal congestion, runny nose, sore throat, myalgia, diarrhea, shortness of breath, and dyspnea in the past 14 days before vaccination; * subject whose sars-cov-2 nucleic acid test result is positive; * subject with a body temperature of ≥ 38.0 °c/100.4 °f (axillary temperature) on the day of enrollment; * subject who has oral ulcers, throat swelling and other oral and nasopharyngeal diseases; * subject with abnormal vital signs, physical examination and laboratory test indicators at screening that are judged by clinicians to be clinically significant; * subject who has a previous history of severe allergy to any drug, food or vaccination, such as urticaria, anaphylactic shock, allergic laryngeal edema, allergic dyspnea, skin eczema, henoch-schonlein purpura, thrombocytopenic purpura, local allergic necrosis reaction (arthus reaction), etc.; * subject who has suffered from acute disease or in the acute attack stage of chronic disease within 3 days before vaccination, or has used antipyretic, analgesic and anti-allergy drugs; * subject within 6 months prior to vaccination participation in a coronavirus (mers-cov, sars-cov-2) vaccine and/or drug (small molecule) and/or antibody study; participation in any clinical study within 3 months prior to vaccination or planned participation in other (drug or vaccine) clinical studies during the study; * subject who has received other vaccines within 1 month before vaccination; * subject who has used immunoenhancers or immunosuppressants in the past 3 months; * subject who was diagnosed with congenital or acquired immunodeficiency, or suspected to have systemic diseases that may interfere with the conduct or completion of the study, such as tuberculosis, hepatitis b, hepatitis c, human immunodeficiency virus (hiv), syphilis infection, etc.; * subject who was diagnosed with serious diseases, congenital anomalies or chronic disease that may interfere with the conduct or completion of the study (including but not limited to: allergy to vaccines, asthma and other respiratory diseases or chronic bronchitis, hypertension, hypotension, heart disease, kidney disease, diabetes mellitus (type 1 or type 2), autoimmune diseases, thalassemia, malignant tumor, atopy, existing skin diseases, etc.); * subject who has received blood or blood-related products (such as blood transfusion, use of human albumin, human immunoglobulin, etc.) within the past 6 months; * subject with a history or family history of convulsions, epilepsy, encephalopathy and psychosis; * subject with functional asplenia or splenectomy caused by any situation; * subject who has any condition that, in the opinion of the investigator, may interfere with the evaluation of the objectives of the study.

those who had fever (body temperature≥ 38.0 °c/100.4 °f), dry cough, fatigue, nasal congestion, runny nose, sore throat, myalgia, diarrhea, shortness of breath, and dyspnea in the past 14 days before vaccination; subject whose sars-cov-2 nucleic acid test result is positive; subject with a body temperature of ≥ 38.0 °c/100.4 °f (axillary temperature) on the day of enrollment; subject who has oral ulcers, throat swelling and other oral and nasopharyngeal diseases; subject with abnormal vital signs, physical examination and laboratory test indicators at screening that are judged by clinicians to be clinically significant; subject who has a previous history of severe allergy to any drug, food or vaccination, such as urticaria, anaphylactic shock, allergic laryngeal edema, allergic dyspnea, skin eczema, henoch-schonlein purpura, thrombocytopenic purpura, local allergic necrosis reaction (arthus reaction), etc.; subject who has suffered from acute disease or in the acute attack stage of chronic disease within 3 days before vaccination, or has used antipyretic, analgesic and anti-allergy drugs; subject within 6 months prior to vaccination participation in a coronavirus (mers-cov, sars-cov-2) vaccine and/or drug (small molecule) and/or antibody study; participation in any clinical study within 3 months prior to vaccination or planned participation in other (drug or vaccine) clinical studies during the study; subject who has received other vaccines within 1 month before vaccination; subject who has used immunoenhancers or immunosuppressants in the past 3 months; subject who was diagnosed with congenital or acquired immunodeficiency, or suspected to have systemic diseases that may interfere with the conduct or completion of the study, such as tuberculosis, hepatitis b, hepatitis c, human immunodeficiency virus (hiv), syphilis infection, etc.; subject who was diagnosed with serious diseases, congenital anomalies or chronic disease that may interfere with the conduct or completion of the study (including but not limited to: allergy to vaccines, asthma and other respiratory diseases or chronic bronchitis, hypertension, hypotension, heart disease, kidney disease, diabetes mellitus (type 1 or type 2), autoimmune diseases, thalassemia, malignant tumor, atopy, existing skin diseases, etc.); subject who has received blood or blood-related products (such as blood transfusion, use of human albumin, human immunoglobulin, etc.) within the past 6 months; subject with a history or family history of convulsions, epilepsy, encephalopathy and psychosis; subject with functional asplenia or splenectomy caused by any situation; subject who has any condition that, in the opinion of the investigator, may interfere with the evaluation of the objectives of the study.

those who had fever (body temperature≥ 38.0 °c/100.4 °f), dry cough, fatigue, nasal congestion, runny nose, sore throat, myalgia, diarrhea, shortness of breath, and dyspnea in the past 14 days before vaccination; subject whose sars-cov-2 nucleic acid test result is positive; subject with a body temperature of ≥ 38.0 °c/100.4 °f (axillary temperature) on the day of enrollment; subject who has oral ulcers, throat swelling and other oral and nasopharyngeal diseases; subject with abnormal vital signs, physical examination and laboratory test indicators at screening that are judged by clinicians to be clinically significant; subject who has a previous history of severe allergy to any drug, food or vaccination, such as urticaria, anaphylactic shock, allergic laryngeal edema, allergic dyspnea, skin eczema, henoch-schonlein purpura, thrombocytopenic purpura, local allergic necrosis reaction (arthus reaction), etc.; subject who has suffered from acute disease or in the acute attack stage of chronic disease within 3 days before vaccination, or has used antipyretic, analgesic and anti-allergy drugs; subject within 6 months prior to vaccination participation in a coronavirus (mers-cov, sars-cov-2) vaccine and/or drug (small molecule) and/or antibody study; participation in any clinical study within 3 months prior to vaccination or planned participation in other (drug or vaccine) clinical studies during the study; subject who has received other vaccines within 1 month before vaccination; subject who has used immunoenhancers or immunosuppressants in the past 3 months; subject who was diagnosed with congenital or acquired immunodeficiency, or suspected to have systemic diseases that may interfere with the conduct or completion of the study, such as tuberculosis, hepatitis b, hepatitis c, human immunodeficiency virus (hiv), syphilis infection, etc.; subject who was diagnosed with serious diseases, congenital anomalies or chronic disease that may interfere with the conduct or completion of the study (including but not limited to: allergy to vaccines, asthma and other respiratory diseases or chronic bronchitis, hypertension, hypotension, heart disease, kidney disease, diabetes mellitus (type 1 or type 2), autoimmune diseases, thalassemia, malignant tumor, atopy, existing skin diseases, etc.); subject who has received blood or blood-related products (such as blood transfusion, use of human albumin, human immunoglobulin, etc.) within the past 6 months; subject with a history or family history of convulsions, epilepsy, encephalopathy and psychosis; subject with functional asplenia or splenectomy caused by any situation; subject who has any condition that, in the opinion of the investigator, may interfere with the evaluation of the objectives of the study.