inclusion criteria: * age ≥18 years old * confirmed sars-cov-2 infection as determined by polymerase chain reaction (pcr) in sputum, nasopharyngeal swabs, or oropharyngeal swabs * diagnosis of acute respiratory distress syndrome (ards) according to the berlin definition criteria * onset of ards less than 72 hours before randomization * written informed consent

inclusion criteria: * age ≥18 years old * confirmed sars-cov-2 infection as determined by polymerase chain reaction (pcr) in sputum, nasopharyngeal swabs, or oropharyngeal swabs * diagnosis of acute respiratory distress syndrome (ards) according to the berlin definition criteria * onset of ards less than 72 hours before randomization * written informed consent

inclusion criteria: age ≥18 years old confirmed sars-cov-2 infection as determined by polymerase chain reaction (pcr) in sputum, nasopharyngeal swabs, or oropharyngeal swabs diagnosis of acute respiratory distress syndrome (ards) according to the berlin definition criteria onset of ards less than 72 hours before randomization written informed consent

inclusion criteria: age ≥18 years old confirmed sars-cov-2 infection as determined by polymerase chain reaction (pcr) in sputum, nasopharyngeal swabs, or oropharyngeal swabs diagnosis of acute respiratory distress syndrome (ards) according to the berlin definition criteria onset of ards less than 72 hours before randomization written informed consent