inclusion criteria: 1. availability of signed informed consent 2. adult men and women aged 18-60 3. diagnosed "healthy" according to the data of standard clinical, laboratory and instrumental examination methods, with the absence of clinically significant changes 4. body mass index (bmi): 18.5≤ bmi ≤30 kg/m2 5. hi antibody titers ≤1:20 to influenza a/h1n1pdm09 and a/h3n2 (only for phase 1) 6. serum antibodies to the sars-cov-2 n-protein not higher than 100 bau/ml 7. the ability and willingness to make entries in the diary of self-observation, as well as to carry out all the visits foreseen in the study for control medical observation 8. negative test for alcohol in exhaled air 9. consent to use effective contraceptive methods throughout their participation in the study 10. values of the complete blood count and biochemical blood analysis (during the screening) within 0.9\*reference range lower limit and 1,1 \* reference range upper limit 11. negative tests for hiv, hepatitis b, hepatitis c, and syphilis

inclusion criteria: 1. availability of signed informed consent 2. adult men and women aged 18-60 3. diagnosed "healthy" according to the data of standard clinical, laboratory and instrumental examination methods, with the absence of clinically significant changes 4. body mass index (bmi): 18.5≤ bmi ≤30 kg/m2 5. hi antibody titers ≤1:20 to influenza a/h1n1pdm09 and a/h3n2 (only for phase 1) 6. serum antibodies to the sars-cov-2 n-protein not higher than 100 bau/ml 7. the ability and willingness to make entries in the diary of self-observation, as well as to carry out all the visits foreseen in the study for control medical observation 8. negative test for alcohol in exhaled air 9. consent to use effective contraceptive methods throughout their participation in the study 10. values of the complete blood count and biochemical blood analysis (during the screening) within 0.9\*reference range lower limit and 1,1 \* reference range upper limit 11. negative tests for hiv, hepatitis b, hepatitis c, and syphilis

inclusion criteria: availability of signed informed consent adult men and women aged 18-60 diagnosed "healthy" according to the data of standard clinical, laboratory and instrumental examination methods, with the absence of clinically significant changes body mass index (bmi): 18.5≤ bmi ≤30 kg/m2 hi antibody titers ≤1:20 to influenza a/h1n1pdm09 and a/h3n2 (only for phase 1) serum antibodies to the sars-cov-2 n-protein not higher than 100 bau/ml the ability and willingness to make entries in the diary of self-observation, as well as to carry out all the visits foreseen in the study for control medical observation negative test for alcohol in exhaled air consent to use effective contraceptive methods throughout their participation in the study values of the complete blood count and biochemical blood analysis (during the screening) within 0.9*reference range lower limit and 1,1 * reference range upper limit negative tests for hiv, hepatitis b, hepatitis c, and syphilis

inclusion criteria: availability of signed informed consent adult men and women aged 18-60 diagnosed "healthy" according to the data of standard clinical, laboratory and instrumental examination methods, with the absence of clinically significant changes body mass index (bmi): 18.5≤ bmi ≤30 kg/m2 hi antibody titers ≤1:20 to influenza a/h1n1pdm09 and a/h3n2 (only for phase 1) serum antibodies to the sars-cov-2 n-protein not higher than 100 bau/ml the ability and willingness to make entries in the diary of self-observation, as well as to carry out all the visits foreseen in the study for control medical observation negative test for alcohol in exhaled air consent to use effective contraceptive methods throughout their participation in the study values of the complete blood count and biochemical blood analysis (during the screening) within 0.9*reference range lower limit and 1,1 * reference range upper limit negative tests for hiv, hepatitis b, hepatitis c, and syphilis