inclusion criteria: 1. age ≥18 years old, male or female; 2. patients with clinically confirmed 2019-ncov infection (severe) in accordance with the national health commission's "diagnosis and treatment protocol for novel coronavirus infection (trial version 10)";; 3. agree to use a highly effective non-pharmacologic contraceptive method within 3 months after signing icf to the end of the trial; 4. subjects must be able to understand the study and willing to participate in the study, and sign an informed consent form (if the researcher believes that it is in the interests of the subjects to participate in the study, the informed consent form should be signed by the legal guardian of the subjects and explained in the original medical records and other relevant documents).

inclusion criteria: 1. age ≥18 years old, male or female; 2. patients with clinically confirmed 2019-ncov infection (severe) in accordance with the national health commission's "diagnosis and treatment protocol for novel coronavirus infection (trial version 10)";; 3. agree to use a highly effective non-pharmacologic contraceptive method within 3 months after signing icf to the end of the trial; 4. subjects must be able to understand the study and willing to participate in the study, and sign an informed consent form (if the researcher believes that it is in the interests of the subjects to participate in the study, the informed consent form should be signed by the legal guardian of the subjects and explained in the original medical records and other relevant documents).

inclusion criteria: age ≥18 years old, male or female; patients with clinically confirmed 2019-ncov infection (severe) in accordance with the national health commission's "diagnosis and treatment protocol for novel coronavirus infection (trial version 10)";; agree to use a highly effective non-pharmacologic contraceptive method within 3 months after signing icf to the end of the trial; subjects must be able to understand the study and willing to participate in the study, and sign an informed consent form (if the researcher believes that it is in the interests of the subjects to participate in the study, the informed consent form should be signed by the legal guardian of the subjects and explained in the original medical records and other relevant documents).

inclusion criteria: age ≥18 years old, male or female; patients with clinically confirmed 2019-ncov infection (severe) in accordance with the national health commission's "diagnosis and treatment protocol for novel coronavirus infection (trial version 10)";; agree to use a highly effective non-pharmacologic contraceptive method within 3 months after signing icf to the end of the trial; subjects must be able to understand the study and willing to participate in the study, and sign an informed consent form (if the researcher believes that it is in the interests of the subjects to participate in the study, the informed consent form should be signed by the legal guardian of the subjects and explained in the original medical records and other relevant documents).

inclusion criteria: age 18 to 80 (including 18 and 80 years old), male and female， by pcr detection method for nucleic acid amplification, laboratory confirmed sars - cov - 2 adults infected (within 72 hours before delivery) for the first time; comply with national weijianwei "new coronavirus infection pneumonia diagnosis and treatment plan 9 (trial version)" clinical confirmed new coronavirus pneumonia patients (heavy); agree to sign a consent form to test within 6 months after the effective non-pharmaceutical precautions; participants must be able to understand and willing to participate in this research, this study and signed informed consent form (if incapacitated subjects, the researchers believe the subjects to the test in its own interests, should be signed by its legal guardian informed consent, or telephone inform consent (recording) and note it in the original medical records and other relevant documents).

inclusion criteria: age 18 to 80 (including 18 and 80 years old), male and female， by pcr detection method for nucleic acid amplification, laboratory confirmed sars - cov - 2 adults infected (within 72 hours before delivery) for the first time; comply with national weijianwei "new coronavirus infection pneumonia diagnosis and treatment plan 9 (trial version)" clinical confirmed new coronavirus pneumonia patients (heavy); agree to sign a consent form to test within 6 months after the effective non-pharmaceutical precautions; participants must be able to understand and willing to participate in this research, this study and signed informed consent form (if incapacitated subjects, the researchers believe the subjects to the test in its own interests, should be signed by its legal guardian informed consent, or telephone inform consent (recording) and note it in the original medical records and other relevant documents).