* contraindication to transfusion or history of previous reactions to blood products for transfusion; * pregnant women; * limiting comorbidity for administering the therapies provided for in this protocol in the opinion of the investigator. donor inclusion criteria for plasmapheresis: * convalescent plasma donation will be eligible for patients ≥ 18 years old who had previously confirmed covid-19 by rt-pcr, which met the criteria adopted by technical notes n13 and 21/2020-cgsh/daet/saes/ms; * sars-cov-2 negative rt-pcr; * asymptomatic for at least 14 days; * sars-cov-2 anti-peak titre with dilution ≥ 1: 320; * sign the consent form. donor

* contraindication to transfusion or history of previous reactions to blood products for transfusion; * pregnant women; * limiting comorbidity for administering the therapies provided for in this protocol in the opinion of the investigator. donor inclusion criteria for plasmapheresis: * convalescent plasma donation will be eligible for patients ≥ 18 years old who had previously confirmed covid-19 by rt-pcr, which met the criteria adopted by technical notes n13 and 21/2020-cgsh/daet/saes/ms; * sars-cov-2 negative rt-pcr; * asymptomatic for at least 14 days; * sars-cov-2 anti-peak titre with dilution ≥ 1: 320; * sign the consent form. donor

- contraindication to transfusion or history of previous reactions to blood products for transfusion; - pregnant women; - limiting comorbidity for administering the therapies provided for in this protocol in the opinion of the investigator. donor inclusion criteria for plasmapheresis: - convalescent plasma donation will be eligible for patients ≥ 18 years old who had previously confirmed covid-19 by rt-pcr, which met the criteria adopted by technical notes n13 and 21/2020-cgsh/daet/saes/ms; - sars-cov-2 negative rt-pcr; - asymptomatic for at least 14 days; - sars-cov-2 anti-peak titre with dilution ≥ 1: 320; - sign the consent form. donor

- contraindication to transfusion or history of previous reactions to blood products for transfusion; - pregnant women; - limiting comorbidity for administering the therapies provided for in this protocol in the opinion of the investigator. donor inclusion criteria for plasmapheresis: - convalescent plasma donation will be eligible for patients ≥ 18 years old who had previously confirmed covid-19 by rt-pcr, which met the criteria adopted by technical notes n13 and 21/2020-cgsh/daet/saes/ms; - sars-cov-2 negative rt-pcr; - asymptomatic for at least 14 days; - sars-cov-2 anti-peak titre with dilution ≥ 1: 320; - sign the consent form. donor