1. contacts with covid-19 patients for 14 days prior to the start of the clinical trial. 2. hypersensitivity to any component of the product, allergy to the components of the vaccine. 3. the history of allergic reactions to any vaccination in the past. 4. serious post-vaccination reactions/complications associated with any vaccination in the past. 5. pregnancy and breastfeeding. 6. military personnel on conscription. 7. persons detained in pre-trial detention facilities and those serving sentences in prison. 8. children under the age of 18. 9. symptoms of any disease at the time of inclusion in the study or if it has passed less than 4 weeks since recovery. 10. the history of any acute respiratory disease within less than 3 months prior to inclusion in the study. 11. the history of acute infectious or non-communicable diseases, exacerbation of chronic diseases within less than 4 weeks before the start of the study. 12. the history of tuberculosis (pulmonary and extrapulmonary), cancer, autoimmune diseases, skin diseases (pemphigus, psoriasis, eczema, atopic dermatitis). 13. long-term use (more than 14 days) of immunosuppressive drug, systemic glucocorticosteroids or immunomodulatory drugs within 6 months prior to the study. 14. vaccination with any vaccine within one month prior to vaccination. 15. taking immunoglobulin drugs or blood products within last 3 months prior to the study. 16. the history of treatment with human immunoglobulin drugs within, less than 6 months since such treatment. 17. donation (450 ml of blood or plasma and more) within less than 2 months prior to the study. 18. acute or chronic diseases of the cardiovascular, bronchopulmonary, neuroendocrine system, as well as diseases of the gastrointestinal tract, liver, kidneys, surgery on the gastrointestinal tract (except appendectomy). 19. the history of participation in other clinical trials within less than 3 months prior to the start of this study. 20. individuals with alcohol, drug dependence or drug addiction. taking more than 10 units of alcohol per week (1 unit of alcohol is equivalent to 1/2 litre of beer, 200 ml of wine or 50 ml of alcohol) or anamnestic information about alcoholism, drug addiction, and substance misuse. individuals with positive results of urine examination for drugs and/or with alcohol findings in the exhaled air during the visits. 21. mental illness and neurasthenia. 22. non-compliance with the inclusion criteria. 23. women in the premenopausal period (the last menstruation ≤ 1 year prior to the signing of informed consent) who are not surgically sterile and women who have reproductive potential, but do not use acceptable birth controls or do not plan to use them throughout the study and do not agree to a urine test for pregnancy during the participation in the study. 24. positive test for hiv, viral hepatitis b and c, lues venerea. 25. other comorbidities that the researcher believes may interfere with the evaluation of the study's objectives. and: 1. the researcher's decision to exclude the volunteer for the benefit of the volunteer. 2. false inclusion (violation of inclusion and non-inclusion criteria) or the appearance of non-inclusion criteria during the study. 3. the decision of the researcher or the customer to exclude the volunteer from the study due to a clinically significant deviation from the protocol/violation of the protocol. 4. any undesirable phenomenon requiring the appointment of drugs not authorized by the protocol of this study. 5. refusal of a volunteer to continue to participate in the study or his/her indiscipline. 6. volunteer's desire to complete the study early for any reason. 7. volunteer's failure to show up for a scheduled visit without the researcher's warning or loss of communication with the volunteer.

1. contacts with covid-19 patients for 14 days prior to the start of the clinical trial. 2. hypersensitivity to any component of the product, allergy to the components of the vaccine. 3. the history of allergic reactions to any vaccination in the past. 4. serious post-vaccination reactions/complications associated with any vaccination in the past. 5. pregnancy and breastfeeding. 6. military personnel on conscription. 7. persons detained in pre-trial detention facilities and those serving sentences in prison. 8. children under the age of 18. 9. symptoms of any disease at the time of inclusion in the study or if it has passed less than 4 weeks since recovery. 10. the history of any acute respiratory disease within less than 3 months prior to inclusion in the study. 11. the history of acute infectious or non-communicable diseases, exacerbation of chronic diseases within less than 4 weeks before the start of the study. 12. the history of tuberculosis (pulmonary and extrapulmonary), cancer, autoimmune diseases, skin diseases (pemphigus, psoriasis, eczema, atopic dermatitis). 13. long-term use (more than 14 days) of immunosuppressive drug, systemic glucocorticosteroids or immunomodulatory drugs within 6 months prior to the study. 14. vaccination with any vaccine within one month prior to vaccination. 15. taking immunoglobulin drugs or blood products within last 3 months prior to the study. 16. the history of treatment with human immunoglobulin drugs within, less than 6 months since such treatment. 17. donation (450 ml of blood or plasma and more) within less than 2 months prior to the study. 18. acute or chronic diseases of the cardiovascular, bronchopulmonary, neuroendocrine system, as well as diseases of the gastrointestinal tract, liver, kidneys, surgery on the gastrointestinal tract (except appendectomy). 19. the history of participation in other clinical trials within less than 3 months prior to the start of this study. 20. individuals with alcohol, drug dependence or drug addiction. taking more than 10 units of alcohol per week (1 unit of alcohol is equivalent to 1/2 litre of beer, 200 ml of wine or 50 ml of alcohol) or anamnestic information about alcoholism, drug addiction, and substance misuse. individuals with positive results of urine examination for drugs and/or with alcohol findings in the exhaled air during the visits. 21. mental illness and neurasthenia. 22. non-compliance with the inclusion criteria. 23. women in the premenopausal period (the last menstruation ≤ 1 year prior to the signing of informed consent) who are not surgically sterile and women who have reproductive potential, but do not use acceptable birth controls or do not plan to use them throughout the study and do not agree to a urine test for pregnancy during the participation in the study. 24. positive test for hiv, viral hepatitis b and c, lues venerea. 25. other comorbidities that the researcher believes may interfere with the evaluation of the study's objectives. and: 1. the researcher's decision to exclude the volunteer for the benefit of the volunteer. 2. false inclusion (violation of inclusion and non-inclusion criteria) or the appearance of non-inclusion criteria during the study. 3. the decision of the researcher or the customer to exclude the volunteer from the study due to a clinically significant deviation from the protocol/violation of the protocol. 4. any undesirable phenomenon requiring the appointment of drugs not authorized by the protocol of this study. 5. refusal of a volunteer to continue to participate in the study or his/her indiscipline. 6. volunteer's desire to complete the study early for any reason. 7. volunteer's failure to show up for a scheduled visit without the researcher's warning or loss of communication with the volunteer.

contacts with covid-19 patients for 14 days prior to the start of the clinical trial. hypersensitivity to any component of the product, allergy to the components of the vaccine. the history of allergic reactions to any vaccination in the past. serious post-vaccination reactions/complications associated with any vaccination in the past. pregnancy and breastfeeding. military personnel on conscription. persons detained in pre-trial detention facilities and those serving sentences in prison. children under the age of 18. symptoms of any disease at the time of inclusion in the study or if it has passed less than 4 weeks since recovery. the history of any acute respiratory disease within less than 3 months prior to inclusion in the study. the history of acute infectious or non-communicable diseases, exacerbation of chronic diseases within less than 4 weeks before the start of the study. the history of tuberculosis (pulmonary and extrapulmonary), cancer, autoimmune diseases, skin diseases (pemphigus, psoriasis, eczema, atopic dermatitis). long-term use (more than 14 days) of immunosuppressive drug, systemic glucocorticosteroids or immunomodulatory drugs within 6 months prior to the study. vaccination with any vaccine within one month prior to vaccination. taking immunoglobulin drugs or blood products within last 3 months prior to the study. the history of treatment with human immunoglobulin drugs within, less than 6 months since such treatment. donation (450 ml of blood or plasma and more) within less than 2 months prior to the study. acute or chronic diseases of the cardiovascular, bronchopulmonary, neuroendocrine system, as well as diseases of the gastrointestinal tract, liver, kidneys, surgery on the gastrointestinal tract (except appendectomy). the history of participation in other clinical trials within less than 3 months prior to the start of this study. individuals with alcohol, drug dependence or drug addiction. taking more than 10 units of alcohol per week (1 unit of alcohol is equivalent to 1/2 litre of beer, 200 ml of wine or 50 ml of alcohol) or anamnestic information about alcoholism, drug addiction, and substance misuse. individuals with positive results of urine examination for drugs and/or with alcohol findings in the exhaled air during the visits. mental illness and neurasthenia. non-compliance with the inclusion criteria. women in the premenopausal period (the last menstruation ≤ 1 year prior to the signing of informed consent) who are not surgically sterile and women who have reproductive potential, but do not use acceptable birth controls or do not plan to use them throughout the study and do not agree to a urine test for pregnancy during the participation in the study. positive test for hiv, viral hepatitis b and c, lues venerea. other comorbidities that the researcher believes may interfere with the evaluation of the study's objectives. and: the researcher's decision to exclude the volunteer for the benefit of the volunteer. false inclusion (violation of inclusion and non-inclusion criteria) or the appearance of non-inclusion criteria during the study. the decision of the researcher or the customer to exclude the volunteer from the study due to a clinically significant deviation from the protocol/violation of the protocol. any undesirable phenomenon requiring the appointment of drugs not authorized by the protocol of this study. refusal of a volunteer to continue to participate in the study or his/her indiscipline. volunteer's desire to complete the study early for any reason. volunteer's failure to show up for a scheduled visit without the researcher's warning or loss of communication with the volunteer.

contacts with covid-19 patients for 14 days prior to the start of the clinical trial. hypersensitivity to any component of the product, allergy to the components of the vaccine. the history of allergic reactions to any vaccination in the past. serious post-vaccination reactions/complications associated with any vaccination in the past. pregnancy and breastfeeding. military personnel on conscription. persons detained in pre-trial detention facilities and those serving sentences in prison. children under the age of 18. symptoms of any disease at the time of inclusion in the study or if it has passed less than 4 weeks since recovery. the history of any acute respiratory disease within less than 3 months prior to inclusion in the study. the history of acute infectious or non-communicable diseases, exacerbation of chronic diseases within less than 4 weeks before the start of the study. the history of tuberculosis (pulmonary and extrapulmonary), cancer, autoimmune diseases, skin diseases (pemphigus, psoriasis, eczema, atopic dermatitis). long-term use (more than 14 days) of immunosuppressive drug, systemic glucocorticosteroids or immunomodulatory drugs within 6 months prior to the study. vaccination with any vaccine within one month prior to vaccination. taking immunoglobulin drugs or blood products within last 3 months prior to the study. the history of treatment with human immunoglobulin drugs within, less than 6 months since such treatment. donation (450 ml of blood or plasma and more) within less than 2 months prior to the study. acute or chronic diseases of the cardiovascular, bronchopulmonary, neuroendocrine system, as well as diseases of the gastrointestinal tract, liver, kidneys, surgery on the gastrointestinal tract (except appendectomy). the history of participation in other clinical trials within less than 3 months prior to the start of this study. individuals with alcohol, drug dependence or drug addiction. taking more than 10 units of alcohol per week (1 unit of alcohol is equivalent to 1/2 litre of beer, 200 ml of wine or 50 ml of alcohol) or anamnestic information about alcoholism, drug addiction, and substance misuse. individuals with positive results of urine examination for drugs and/or with alcohol findings in the exhaled air during the visits. mental illness and neurasthenia. non-compliance with the inclusion criteria. women in the premenopausal period (the last menstruation ≤ 1 year prior to the signing of informed consent) who are not surgically sterile and women who have reproductive potential, but do not use acceptable birth controls or do not plan to use them throughout the study and do not agree to a urine test for pregnancy during the participation in the study. positive test for hiv, viral hepatitis b and c, lues venerea. other comorbidities that the researcher believes may interfere with the evaluation of the study's objectives. and: the researcher's decision to exclude the volunteer for the benefit of the volunteer. false inclusion (violation of inclusion and non-inclusion criteria) or the appearance of non-inclusion criteria during the study. the decision of the researcher or the customer to exclude the volunteer from the study due to a clinically significant deviation from the protocol/violation of the protocol. any undesirable phenomenon requiring the appointment of drugs not authorized by the protocol of this study. refusal of a volunteer to continue to participate in the study or his/her indiscipline. volunteer's desire to complete the study early for any reason. volunteer's failure to show up for a scheduled visit without the researcher's warning or loss of communication with the volunteer.

1. contacts with covid-19 patients for 14 days prior to the start of the clinical trial. 2. hypersensitivity to any component of the product, allergy to the components of the vaccine. 3. the history of allergic reactions to any vaccination in the past. 4. serious post-vaccination reactions/complications associated with any vaccination in the past. 5. pregnancy and breastfeeding. 6. military personnel on conscription. 7. persons detained in pre-trial detention facilities and those serving sentences in prison. 8. children under the age of 18. 9. symptoms of any disease at the time of inclusion in the study or if it has passed less than 4 weeks since recovery. 10. the history of any acute respiratory disease within less than 3 months prior to inclusion in the study. 11. the history of acute infectious or non-communicable diseases, exacerbation of chronic diseases within less than 4 weeks before the start of the study. 12. the history of tuberculosis (pulmonary and extrapulmonary), cancer, autoimmune diseases, skin diseases (pemphigus, psoriasis, eczema, atopic dermatitis). 13. long-term use (more than 14 days) of immunosuppressive drug, systemic glucocorticosteroids or immunomodulatory drugs within 6 months prior to the study. 14. vaccination with any vaccine within one month prior to vaccination. 15. taking immunoglobulin drugs or blood products within last 3 months prior to the study. 16. the history of treatment with human immunoglobulin drugs within, less than 6 months since such treatment. 17. donation (450 ml of blood or plasma and more) within less than 2 months prior to the study. 18. acute or chronic diseases of the cardiovascular, bronchopulmonary, neuroendocrine system, as well as diseases of the gastrointestinal tract, liver, kidneys, surgery on the gastrointestinal tract (except appendectomy). 19. the history of participation in other clinical trials within less than 3 months prior to the start of this study. 20. individuals with alcohol, drug dependence or drug addiction. taking more than 10 units of alcohol per week (1 unit of alcohol is equivalent to 1/2 litre of beer, 200 ml of wine or 50 ml of alcohol) or anamnestic information about alcoholism, drug addiction, and substance misuse. individuals with positive results of urine examination for drugs and/or with alcohol findings in the exhaled air during the visits. 21. mental illness and neurasthenia. 22. non-compliance with the inclusion criteria. 23. women in the premenopausal period (the last menstruation ≤ 1 year prior to the signing of informed consent) who are not surgically sterile and women who have reproductive potential, but do not use acceptable birth controls or do not plan to use them throughout the study and do not agree to a urine test for pregnancy during the participation in the study. 24. positive test for hiv, viral hepatitis b and c, lues venerea. 25. other comorbidities that the researcher believes may interfere with the evaluation of the study's objectives. and: 1. the researcher's decision to exclude the volunteer for the benefit of the volunteer. 2. false inclusion (violation of inclusion and non-inclusion criteria) or the appearance of non-inclusion criteria during the study. 3. the decision of the researcher or the customer to exclude the volunteer from the study due to a clinically significant deviation from the protocol/violation of the protocol. 4. any undesirable phenomenon requiring the appointment of drugs not authorized by the protocol of this study. 5. refusal of a volunteer to continue to participate in the study or his/her indiscipline. 6. volunteer's desire to complete the study early for any reason. 7. volunteer's failure to show up for a scheduled visit without the researcher's warning or loss of communication with the volunteer.

1. contacts with covid-19 patients for 14 days prior to the start of the clinical trial. 2. hypersensitivity to any component of the product, allergy to the components of the vaccine. 3. the history of allergic reactions to any vaccination in the past. 4. serious post-vaccination reactions/complications associated with any vaccination in the past. 5. pregnancy and breastfeeding. 6. military personnel on conscription. 7. persons detained in pre-trial detention facilities and those serving sentences in prison. 8. children under the age of 18. 9. symptoms of any disease at the time of inclusion in the study or if it has passed less than 4 weeks since recovery. 10. the history of any acute respiratory disease within less than 3 months prior to inclusion in the study. 11. the history of acute infectious or non-communicable diseases, exacerbation of chronic diseases within less than 4 weeks before the start of the study. 12. the history of tuberculosis (pulmonary and extrapulmonary), cancer, autoimmune diseases, skin diseases (pemphigus, psoriasis, eczema, atopic dermatitis). 13. long-term use (more than 14 days) of immunosuppressive drug, systemic glucocorticosteroids or immunomodulatory drugs within 6 months prior to the study. 14. vaccination with any vaccine within one month prior to vaccination. 15. taking immunoglobulin drugs or blood products within last 3 months prior to the study. 16. the history of treatment with human immunoglobulin drugs within, less than 6 months since such treatment. 17. donation (450 ml of blood or plasma and more) within less than 2 months prior to the study. 18. acute or chronic diseases of the cardiovascular, bronchopulmonary, neuroendocrine system, as well as diseases of the gastrointestinal tract, liver, kidneys, surgery on the gastrointestinal tract (except appendectomy). 19. the history of participation in other clinical trials within less than 3 months prior to the start of this study. 20. individuals with alcohol, drug dependence or drug addiction. taking more than 10 units of alcohol per week (1 unit of alcohol is equivalent to 1/2 litre of beer, 200 ml of wine or 50 ml of alcohol) or anamnestic information about alcoholism, drug addiction, and substance misuse. individuals with positive results of urine examination for drugs and/or with alcohol findings in the exhaled air during the visits. 21. mental illness and neurasthenia. 22. non-compliance with the inclusion criteria. 23. women in the premenopausal period (the last menstruation ≤ 1 year prior to the signing of informed consent) who are not surgically sterile and women who have reproductive potential, but do not use acceptable birth controls or do not plan to use them throughout the study and do not agree to a urine test for pregnancy during the participation in the study. 24. positive test for hiv, viral hepatitis b and c, lues venerea. 25. other comorbidities that the researcher believes may interfere with the evaluation of the study's objectives. and: 1. the researcher's decision to exclude the volunteer for the benefit of the volunteer. 2. false inclusion (violation of inclusion and non-inclusion criteria) or the appearance of non-inclusion criteria during the study. 3. the decision of the researcher or the customer to exclude the volunteer from the study due to a clinically significant deviation from the protocol/violation of the protocol. 4. any undesirable phenomenon requiring the appointment of drugs not authorized by the protocol of this study. 5. refusal of a volunteer to continue to participate in the study or his/her indiscipline. 6. volunteer's desire to complete the study early for any reason. 7. volunteer's failure to show up for a scheduled visit without the researcher's warning or loss of communication with the volunteer.

1. contacts with covid-19 patients for 14 days prior to the start of the clinical trial. 2. hypersensitivity to any component of the product, allergy to the components of the vaccine. 3. the history of allergic reactions to any vaccination in the past. 4. serious post-vaccination reactions/complications associated with any vaccination in the past. 5. pregnancy and breastfeeding. 6. military personnel on conscription. 7. persons detained in pre-trial detention facilities and those serving sentences in prison. 8. children under the age of 18. 9. symptoms of any disease at the time of inclusion in the study or if it has passed less than 4 weeks since recovery. 10. the history of any acute respiratory disease within less than 3 months prior to inclusion in the study. 11. the history of acute infectious or non-communicable diseases, exacerbation of chronic diseases within less than 4 weeks before the start of the study. 12. the history of tuberculosis (pulmonary and extrapulmonary), cancer, autoimmune diseases, skin diseases (pemphigus, psoriasis, eczema, atopic dermatitis). 13. long-term use (more than 14 days) of immunosuppressive drug, systemic glucocorticosteroids or immunomodulatory drugs within 6 months prior to the study. 14. vaccination with any vaccine within one month prior to vaccination. 15. taking immunoglobulin drugs or blood products within last 3 months prior to the study. 16. the history of treatment with human immunoglobulin drugs within, less than 6 months since such treatment. 17. donation (450 ml of blood or plasma and more) within less than 2 months prior to the study. 18. acute or chronic diseases of the cardiovascular, bronchopulmonary, neuroendocrine system, as well as diseases of the gastrointestinal tract, liver, kidneys, surgery on the gastrointestinal tract (except appendectomy). 19. the history of participation in other clinical trials within less than 3 months prito the start of this study. 20. individuals with alcohol, drug dependence or drug addiction. taking more than 10 units of alcohol per week (1 unit of alcohol is equivalent to 1/2 litre of beer, 200 ml of wine or 50 ml of alcohol) or anamnestic information about alcoholism, drug addiction, and substance misuse. individuals with positive results of urine examination for drugs and/or with alcohol findings in the exhaled air during the visits. 21. mental illness and neurasthenia. 22. non-compliance with the inclusion criteria. 23. women in the premenopausal period (the last menstruation ≤ 1 year prior to the signing of informed consent) who are not surgically sterile and women who have reproductive potential, but do not use acceptable birth controls or do not plan to use them throughout the study and do not agree to a urine test for pregnancy during the participation in the study. 24. positive test for hiv, viral hepatitis b and c, lues venerea. 25. other comorbidities that the researcher believes may interfere with the evaluation of the study's objectives. and: 1. the researcher's decision to exclude the volunteer for the benefit of the volunteer. 2. false inclusion (violation of inclusion and non-inclusion criteria) or the appearance of non-inclusion criteria during the study. 3. the decision of the researcher or the customer to exclude the volunteer from the study due to a clinically significant deviation from the protocol/violation of the protocol. 4. any undesirable phenomenon requiring the appointment of drugs not authorized by the protocol of this study. 5. refusal of a volunteer to continue to participate in the study or his/her indiscipline. 6. volunteer's desire to complete the study early for any reason. 7. volunteer's failure to show up for a scheduled visit without the researcher's warning or loss of communication with the volunteer.

1. contacts with covid-19 patients for 14 days prior to the start of the clinical trial. 2. hypersensitivity to any component of the product, allergy to the components of the vaccine. 3. the history of allergic reactions to any vaccination in the past. 4. serious post-vaccination reactions/complications associated with any vaccination in the past. 5. pregnancy and breastfeeding. 6. military personnel on conscription. 7. persons detained in pre-trial detention facilities and those serving sentences in prison. 8. children under the age of 18. 9. symptoms of any disease at the time of inclusion in the study or if it has passed less than 4 weeks since recovery. 10. the history of any acute respiratory disease within less than 3 months prior to inclusion in the study. 11. the history of acute infectious or non-communicable diseases, exacerbation of chronic diseases within less than 4 weeks before the start of the study. 12. the history of tuberculosis (pulmonary and extrapulmonary), cancer, autoimmune diseases, skin diseases (pemphigus, psoriasis, eczema, atopic dermatitis). 13. long-term use (more than 14 days) of immunosuppressive drug, systemic glucocorticosteroids or immunomodulatory drugs within 6 months prior to the study. 14. vaccination with any vaccine within one month prior to vaccination. 15. taking immunoglobulin drugs or blood products within last 3 months prior to the study. 16. the history of treatment with human immunoglobulin drugs within, less than 6 months since such treatment. 17. donation (450 ml of blood or plasma and more) within less than 2 months prior to the study. 18. acute or chronic diseases of the cardiovascular, bronchopulmonary, neuroendocrine system, as well as diseases of the gastrointestinal tract, liver, kidneys, surgery on the gastrointestinal tract (except appendectomy). 19. the history of participation in other clinical trials within less than 3 months prito the start of this study. 20. individuals with alcohol, drug dependence or drug addiction. taking more than 10 units of alcohol per week (1 unit of alcohol is equivalent to 1/2 litre of beer, 200 ml of wine or 50 ml of alcohol) or anamnestic information about alcoholism, drug addiction, and substance misuse. individuals with positive results of urine examination for drugs and/or with alcohol findings in the exhaled air during the visits. 21. mental illness and neurasthenia. 22. non-compliance with the inclusion criteria. 23. women in the premenopausal period (the last menstruation ≤ 1 year prior to the signing of informed consent) who are not surgically sterile and women who have reproductive potential, but do not use acceptable birth controls or do not plan to use them throughout the study and do not agree to a urine test for pregnancy during the participation in the study. 24. positive test for hiv, viral hepatitis b and c, lues venerea. 25. other comorbidities that the researcher believes may interfere with the evaluation of the study's objectives. and: 1. the researcher's decision to exclude the volunteer for the benefit of the volunteer. 2. false inclusion (violation of inclusion and non-inclusion criteria) or the appearance of non-inclusion criteria during the study. 3. the decision of the researcher or the customer to exclude the volunteer from the study due to a clinically significant deviation from the protocol/violation of the protocol. 4. any undesirable phenomenon requiring the appointment of drugs not authorized by the protocol of this study. 5. refusal of a volunteer to continue to participate in the study or his/her indiscipline. 6. volunteer's desire to complete the study early for any reason. 7. volunteer's failure to show up for a scheduled visit without the researcher's warning or loss of communication with the volunteer.