1. pregnant or breastfeeding women, or women planning pregnancy during the clinical study; women with childbearing potential (including those who have not been sterilized by surgery and in the postmenopausal period for less than 2 years) who do not use adequate contraception methods. 2. the use of invasive artificial lung ventilation (ialv), plasma transfusion (including plasma of convalescents) and other blood components during therapy against covid-19. 3. chronic airway disease in the past medical history, including idiopathic pulmonary fibrosis (ipf), bronchial asthma, chronic obstructive pulmonary disease (copd), or pulmonary hypertension, diagnosed before covid-19. 4. significant cardiovascular diseases at present time or during 6 months prior to the screening, including: chronic heart failure class iii or iv (according to the new york heart association classification), clinically significant ventricular arrhythmias (ventricular tachycardia, ventricular fibrillation), unstable angina, myocardial infarction, heart and coronary surgery, significant heart valves disease, uncontrolled hypertension with systolic blood pressure\> 180 mm hg and diastolic blood pressure\> 110 mm hg, thromboembolia of the pulmonary artery or deep vein thrombosis 5. nephrotic syndrome, moderate to severe chronic renal failure, or significant kidney disease with a glomerular filtration rate (gfr) \<60 ml/min at the screening visit. 6. cirrhosis of the liver in the past medical history; increase in alanine aminotransferase (alt) and/or aspartate aminotransferase (ast) by 3 or more times from the upper normal level (unl) at the screening visit; an increase in the total bilirubin level by 2 or more times from unl at the screening visit. 7. hemoglobin level \<90 g/l at the screening visit. 8. severe diseases of the central nervous system, including seizures or conditions in the past medical history that can cause their development; stroke or transient ischemic attack within 6 months prior to the screening visit; traumatic brain injury or loss of consciousness within 6 months prior to the screening visit; a brain tumor. 9. signs of severe uncontrolled intercurrent disease, such as disorders of the nervous system, kidney, liver, endocrine system and gastrointestinal tract, which, in the opinion of the investigator, could interfere with the patient's participation in the study. 10. malignant neoplasms requiring chemotherapy treatment within 6 months prior to the screening visit. 11. hiv infection in the past-medical history. 12. prostate cancer or benign prostatic hyperplasia (bph) with residual urine volume of more than 100 ml in the past medical history of men. 13. hypersensitivity or intolerance to any component of the investigated drug. 14. participation in other clinical studies within 2 months prior to the screening visit. 15. administration of the following medications: bronchodilators, anticholinergics, corticosteroids, cytostatics, colchicine, cyclosporin a, interferon-γ-1b, bosentan, macitentan, etanercept, sildenafil, imatinib, n-acetylcysteine, warfarin, ambrisentan, nintedanib, pirfenidone 1 month prior to the screening visit. 16. inability to read or write; unwillingness to understand and follow the procedures of the study protocol; noncompliance with the drugs administration or procedures schedule, which according to the researchers may affect the study results or the patient safety and prevent the further participation of the patient in the study; any other associated medical or serious mental conditions that make the patient inadequate for participation in the clinical study and restrict the validity of informed consent or may affect the patient's ability to participate in the study.

1. pregnant or breastfeeding women, or women planning pregnancy during the clinical study; women with childbearing potential (including those who have not been sterilized by surgery and in the postmenopausal period for less than 2 years) who do not use adequate contraception methods. 2. the use of invasive artificial lung ventilation (ialv), plasma transfusion (including plasma of convalescents) and other blood components during therapy against covid-19. 3. chronic airway disease in the past medical history, including idiopathic pulmonary fibrosis (ipf), bronchial asthma, chronic obstructive pulmonary disease (copd), or pulmonary hypertension, diagnosed before covid-19. 4. significant cardiovascular diseases at present time or during 6 months prior to the screening, including: chronic heart failure class iii or iv (according to the new york heart association classification), clinically significant ventricular arrhythmias (ventricular tachycardia, ventricular fibrillation), unstable angina, myocardial infarction, heart and coronary surgery, significant heart valves disease, uncontrolled hypertension with systolic blood pressure\> 180 mm hg and diastolic blood pressure\> 110 mm hg, thromboembolia of the pulmonary artery or deep vein thrombosis 5. nephrotic syndrome, moderate to severe chronic renal failure, or significant kidney disease with a glomerular filtration rate (gfr) \<60 ml/min at the screening visit. 6. cirrhosis of the liver in the past medical history; increase in alanine aminotransferase (alt) and/or aspartate aminotransferase (ast) by 3 or more times from the upper normal level (unl) at the screening visit; an increase in the total bilirubin level by 2 or more times from unl at the screening visit. 7. hemoglobin level \<90 g/l at the screening visit. 8. severe diseases of the central nervous system, including seizures or conditions in the past medical history that can cause their development; stroke or transient ischemic attack within 6 months prior to the screening visit; traumatic brain injury or loss of consciousness within 6 months prior to the screening visit; a brain tumor. 9. signs of severe uncontrolled intercurrent disease, such as disorders of the nervous system, kidney, liver, endocrine system and gastrointestinal tract, which, in the opinion of the investigator, could interfere with the patient's participation in the study. 10. malignant neoplasms requiring chemotherapy treatment within 6 months prior to the screening visit. 11. hiv infection in the past-medical history. 12. prostate cancer or benign prostatic hyperplasia (bph) with residual urine volume of more than 100 ml in the past medical history of men. 13. hypersensitivity or intolerance to any component of the investigated drug. 14. participation in other clinical studies within 2 months prior to the screening visit. 15. administration of the following medications: bronchodilators, anticholinergics, corticosteroids, cytostatics, colchicine, cyclosporin a, interferon-γ-1b, bosentan, macitentan, etanercept, sildenafil, imatinib, n-acetylcysteine, warfarin, ambrisentan, nintedanib, pirfenidone 1 month prior to the screening visit. 16. inability to read or write; unwillingness to understand and follow the procedures of the study protocol; noncompliance with the drugs administration or procedures schedule, which according to the researchers may affect the study results or the patient safety and prevent the further participation of the patient in the study; any other associated medical or serious mental conditions that make the patient inadequate for participation in the clinical study and restrict the validity of informed consent or may affect the patient's ability to participate in the study.

pregnant or breastfeeding women, or women planning pregnancy during the clinical study; women with childbearing potential (including those who have not been sterilized by surgery and in the postmenopausal period for less than 2 years) who do not use adequate contraception methods. the use of invasive artificial lung ventilation (ialv), plasma transfusion (including plasma of convalescents) and other blood components during therapy against covid-19. chronic airway disease in the past medical history, including idiopathic pulmonary fibrosis (ipf), bronchial asthma, chronic obstructive pulmonary disease (copd), or pulmonary hypertension, diagnosed before covid-19. significant cardiovascular diseases at present time or during 6 months prior to the screening, including: chronic heart failure class iii or iv (according to the new york heart association classification), clinically significant ventricular arrhythmias (ventricular tachycardia, ventricular fibrillation), unstable angina, myocardial infarction, heart and coronary surgery, significant heart valves disease, uncontrolled hypertension with systolic blood pressure> 180 mm hg and diastolic blood pressure> 110 mm hg, thromboembolia of the pulmonary artery or deep vein thrombosis nephrotic syndrome, moderate to severe chronic renal failure, or significant kidney disease with a glomerular filtration rate (gfr) <60 ml/min at the screening visit. cirrhosis of the liver in the past medical history; increase in alanine aminotransferase (alt) and/or aspartate aminotransferase (ast) by 3 or more times from the upper normal level (unl) at the screening visit; an increase in the total bilirubin level by 2 or more times from unl at the screening visit. hemoglobin level <90 g/l at the screening visit. severe diseases of the central nervous system, including seizures or conditions in the past medical history that can cause their development; stroke or transient ischemic attack within 6 months prior to the screening visit; traumatic brain injury or loss of consciousness within 6 months prior to the screening visit; a brain tumor. signs of severe uncontrolled intercurrent disease, such as disorders of the nervous system, kidney, liver, endocrine system and gastrointestinal tract, which, in the opinion of the investigator, could interfere with the patient's participation in the study. malignant neoplasms requiring chemotherapy treatment within 6 months prior to the screening visit. hiv infection in the past-medical history. prostate cancer or benign prostatic hyperplasia (bph) with residual urine volume of more than 100 ml in the past medical history of men. hypersensitivity or intolerance to any component of the investigated drug. participation in other clinical studies within 2 months prior to the screening visit. administration of the following medications: bronchodilators, anticholinergics, corticosteroids, cytostatics, colchicine, cyclosporin a, interferon-γ-1b, bosentan, macitentan, etanercept, sildenafil, imatinib, n-acetylcysteine, warfarin, ambrisentan, nintedanib, pirfenidone 1 month prior to the screening visit. inability to read or write; unwillingness to understand and follow the procedures of the study protocol; noncompliance with the drugs administration or procedures schedule, which according to the researchers may affect the study results or the patient safety and prevent the further participation of the patient in the study; any other associated medical or serious mental conditions that make the patient inadequate for participation in the clinical study and restrict the validity of informed consent or may affect the patient's ability to participate in the study.

pregnant or breastfeeding women, or women planning pregnancy during the clinical study; women with childbearing potential (including those who have not been sterilized by surgery and in the postmenopausal period for less than 2 years) who do not use adequate contraception methods. the use of invasive artificial lung ventilation (ialv), plasma transfusion (including plasma of convalescents) and other blood components during therapy against covid-19. chronic airway disease in the past medical history, including idiopathic pulmonary fibrosis (ipf), bronchial asthma, chronic obstructive pulmonary disease (copd), or pulmonary hypertension, diagnosed before covid-19. significant cardiovascular diseases at present time or during 6 months prior to the screening, including: chronic heart failure class iii or iv (according to the new york heart association classification), clinically significant ventricular arrhythmias (ventricular tachycardia, ventricular fibrillation), unstable angina, myocardial infarction, heart and coronary surgery, significant heart valves disease, uncontrolled hypertension with systolic blood pressure> 180 mm hg and diastolic blood pressure> 110 mm hg, thromboembolia of the pulmonary artery or deep vein thrombosis nephrotic syndrome, moderate to severe chronic renal failure, or significant kidney disease with a glomerular filtration rate (gfr) <60 ml/min at the screening visit. cirrhosis of the liver in the past medical history; increase in alanine aminotransferase (alt) and/or aspartate aminotransferase (ast) by 3 or more times from the upper normal level (unl) at the screening visit; an increase in the total bilirubin level by 2 or more times from unl at the screening visit. hemoglobin level <90 g/l at the screening visit. severe diseases of the central nervous system, including seizures or conditions in the past medical history that can cause their development; stroke or transient ischemic attack within 6 months prior to the screening visit; traumatic brain injury or loss of consciousness within 6 months prior to the screening visit; a brain tumor. signs of severe uncontrolled intercurrent disease, such as disorders of the nervous system, kidney, liver, endocrine system and gastrointestinal tract, which, in the opinion of the investigator, could interfere with the patient's participation in the study. malignant neoplasms requiring chemotherapy treatment within 6 months prior to the screening visit. hiv infection in the past-medical history. prostate cancer or benign prostatic hyperplasia (bph) with residual urine volume of more than 100 ml in the past medical history of men. hypersensitivity or intolerance to any component of the investigated drug. participation in other clinical studies within 2 months prior to the screening visit. administration of the following medications: bronchodilators, anticholinergics, corticosteroids, cytostatics, colchicine, cyclosporin a, interferon-γ-1b, bosentan, macitentan, etanercept, sildenafil, imatinib, n-acetylcysteine, warfarin, ambrisentan, nintedanib, pirfenidone 1 month prior to the screening visit. inability to read or write; unwillingness to understand and follow the procedures of the study protocol; noncompliance with the drugs administration or procedures schedule, which according to the researchers may affect the study results or the patient safety and prevent the further participation of the patient in the study; any other associated medical or serious mental conditions that make the patient inadequate for participation in the clinical study and restrict the validity of informed consent or may affect the patient's ability to participate in the study.

1. pregnant or breastfeeding women, or women planning pregnancy during the clinical study; women with childbearing potential (including those who have not been sterilized by surgery and in the postmenopausal period for less than 2 years) who do not use adequate contraception methods. 2. the use of invasive artificial lung ventilation (ialv), plasma transfusion (including plasma of convalescents) and other blood components during therapy against covid-19. 3. chronic airway disease in the past medical history, including idiopathic pulmonary fibrosis (ipf), bronchial asthma, chronic obstructive pulmonary disease (copd), or pulmonary hypertension, diagnosed before covid-19. 4. significant cardiovascular diseases at present time or during 6 months prior to the screening, including: chronic heart failure class iii or iv (according to the new york heart association classification), clinically significant ventricular arrhythmias (ventricular tachycardia, ventricular fibrillation), unstable angina, myocardial infarction, heart and coronary surgery, significant heart valves disease, uncontrolled hypertension with systolic blood pressure> 180 mm hg and diastolic blood pressure> 110 mm hg, thromboembolia of the pulmonary artery or deep vein thrombosis 5. nephrotic syndrome, moderate to severe chronic renal failure, or significant kidney disease with a glomerular filtration rate (gfr) <60 ml/min at the screening visit. 6. cirrhosis of the liver in the past medical history; increase in alanine aminotransferase (alt) and/or aspartate aminotransferase (ast) by 3 or more times from the upper normal level (unl) at the screening visit; an increase in the total bilirubin level by 2 or more times from unl at the screening visit. 7. hemoglobin level <90 g/l at the screening visit. 8. severe diseases of the central nervous system, including seizures or conditions in the past medical history that can cause their development; stroke or transient ischemic attack within 6 months prior to the screening visit; traumatic brain injury or loss of consciousness within 6 months prior to the screening visit; a brain tumor. 9. signs of severe uncontrolled intercurrent disease, such as disorders of the nervous system, kidney, liver, endocrine system and gastrointestinal tract, which, in the opinion of the investigator, could interfere with the patient's participation in the study. 10. malignant neoplasms requiring chemotherapy treatment within 6 months prior to the screening visit. 11. hiv infection in the past-medical history. 12. prostate cancer or benign prostatic hyperplasia (bph) with residual urine volume of more than 100 ml in the past medical history of men. 13. hypersensitivity or intolerance to any component of the investigated drug. 14. participation in other clinical studies within 2 months prior to the screening visit. 15. administration of the following medications: bronchodilators, anticholinergics, corticosteroids, cytostatics, colchicine, cyclosporin a, interferon-γ-1b, bosentan, macitentan, etanercept, sildenafil, imatinib, n-acetylcysteine, warfarin, ambrisentan, nintedanib, pirfenidone 1 month prior to the screening visit. 16. inability to read or write; unwillingness to understand and follow the procedures of the study protocol; noncompliance with the drugs administration or procedures schedule, which according to the researchers may affect the study results or the patient safety and prevent the further participation of the patient in the study; any other associated medical or serious mental conditions that make the patient inadequate for participation in the clinical study and restrict the validity of informed consent or may affect the patient's ability to participate in the study.

1. pregnant or breastfeeding women, or women planning pregnancy during the clinical study; women with childbearing potential (including those who have not been sterilized by surgery and in the postmenopausal period for less than 2 years) who do not use adequate contraception methods. 2. the use of invasive artificial lung ventilation (ialv), plasma transfusion (including plasma of convalescents) and other blood components during therapy against covid-19. 3. chronic airway disease in the past medical history, including idiopathic pulmonary fibrosis (ipf), bronchial asthma, chronic obstructive pulmonary disease (copd), or pulmonary hypertension, diagnosed before covid-19. 4. significant cardiovascular diseases at present time or during 6 months prior to the screening, including: chronic heart failure class iii or iv (according to the new york heart association classification), clinically significant ventricular arrhythmias (ventricular tachycardia, ventricular fibrillation), unstable angina, myocardial infarction, heart and coronary surgery, significant heart valves disease, uncontrolled hypertension with systolic blood pressure> 180 mm hg and diastolic blood pressure> 110 mm hg, thromboembolia of the pulmonary artery or deep vein thrombosis 5. nephrotic syndrome, moderate to severe chronic renal failure, or significant kidney disease with a glomerular filtration rate (gfr) <60 ml/min at the screening visit. 6. cirrhosis of the liver in the past medical history; increase in alanine aminotransferase (alt) and/or aspartate aminotransferase (ast) by 3 or more times from the upper normal level (unl) at the screening visit; an increase in the total bilirubin level by 2 or more times from unl at the screening visit. 7. hemoglobin level <90 g/l at the screening visit. 8. severe diseases of the central nervous system, including seizures or conditions in the past medical history that can cause their development; stroke or transient ischemic attack within 6 months prior to the screening visit; traumatic brain injury or loss of consciousness within 6 months prior to the screening visit; a brain tumor. 9. signs of severe uncontrolled intercurrent disease, such as disorders of the nervous system, kidney, liver, endocrine system and gastrointestinal tract, which, in the opinion of the investigator, could interfere with the patient's participation in the study. 10. malignant neoplasms requiring chemotherapy treatment within 6 months prior to the screening visit. 11. hiv infection in the past-medical history. 12. prostate cancer or benign prostatic hyperplasia (bph) with residual urine volume of more than 100 ml in the past medical history of men. 13. hypersensitivity or intolerance to any component of the investigated drug. 14. participation in other clinical studies within 2 months prior to the screening visit. 15. administration of the following medications: bronchodilators, anticholinergics, corticosteroids, cytostatics, colchicine, cyclosporin a, interferon-γ-1b, bosentan, macitentan, etanercept, sildenafil, imatinib, n-acetylcysteine, warfarin, ambrisentan, nintedanib, pirfenidone 1 month prior to the screening visit. 16. inability to read or write; unwillingness to understand and follow the procedures of the study protocol; noncompliance with the drugs administration or procedures schedule, which according to the researchers may affect the study results or the patient safety and prevent the further participation of the patient in the study; any other associated medical or serious mental conditions that make the patient inadequate for participation in the clinical study and restrict the validity of informed consent or may affect the patient's ability to participate in the study.