Patients suffering from underlying diseases including pulmonary hypertension, kidney failure, seizures, depression, chronic hepatitis, cirrhosis and cholestatic liver diseases and pulmonary embolism (in the past 3 months) Use of anti-coagulant drugs such as warfarin, hormonal drugs and other illegal drugs (within the past 30 days) Alcohol consumption Pregnancy or breastfeeding Allergy to AAT drug Having IgA deficiency No smoking in the last 6 months

Patients suffering from underlying diseases including pulmonary hypertension, kidney failure, seizures, depression, chronic hepatitis, cirrhosis and cholestatic liver diseases and pulmonary embolism (in the past 3 months) Use of anti-coagulant drugs such as warfarin, hormonal drugs and other illegal drugs (within the past 30 days) Alcohol consumption Pregnancy or breastfeeding Allergy to AAT drug Having IgA deficiency No smoking in the last 6 months