Created at	Source	Raw Value	Validated value
June 14, 2024, 8 p.m.	usa	Total number of participants enrolled in each Appendix	Total number of participants enrolled in each Appendix
Oct. 28, 2022, noon	usa	Change in Autonomic dysfunction symptom cluster, as measured by the orthostatic hypotension questionnaire (OHQ);Change in Cognitive dysfunction symptom cluster, as measured by Patient-Reported Outcomes Measurement Information System (PROMIS) cognitive function T-score;Change in Exercise intolerance symptom cluster, as measured by the Modified Depaul Symptom Questionnaire-Post Exertional Malaise (DSQ-PEM)	Change in Autonomic dysfunction symptom cluster, as measured by the orthostatic hypotension questionnaire (OHQ);Change in Cognitive dysfunction symptom cluster, as measured by Patient-Reported Outcomes Measurement Information System (PROMIS) cognitive function T-score;Change in Exercise intolerance symptom cluster, as measured by the Modified Depaul Symptom Questionnaire-Post Exertional Malaise (DSQ-PEM)