1. brief interview of mental status (bims) score \<8 (indicating severe dementia). 2. prior vaccination with the shingrix. 3. positive test for covid 19 or prior history of covid 19 infection. 4. conditions that confound the interpretation of the innate immune measures. (i.e. terminal condition, receiving hospice, stage 3 and 4 open wound, chemotherapy, immune modulators or other immunosuppressants, autoimmune disorders, and bmi \< 20 kg/m2). 5. conditions that confound interpretation of respiratory symptoms. (i.e ventilator dependent, receiving more that 2-3 liters/min of oxygen by nasal cannula, chronic diarrhea, recurrent infections).

1. brief interview of mental status (bims) score \<8 (indicating severe dementia). 2. prior vaccination with the shingrix. 3. positive test for covid 19 or prior history of covid 19 infection. 4. conditions that confound the interpretation of the innate immune measures. (i.e. terminal condition, receiving hospice, stage 3 and 4 open wound, chemotherapy, immune modulators or other immunosuppressants, autoimmune disorders, and bmi \< 20 kg/m2). 5. conditions that confound interpretation of respiratory symptoms. (i.e ventilator dependent, receiving more that 2-3 liters/min of oxygen by nasal cannula, chronic diarrhea, recurrent infections).

brief interview of mental status (bims) score <8 (indicating severe dementia). prior vaccination with the shingrix. positive test for covid 19 or prior history of covid 19 infection. conditions that confound the interpretation of the innate immune measures. (i.e. terminal condition, receiving hospice, stage 3 and 4 open wound, chemotherapy, immune modulators or other immunosuppressants, autoimmune disorders, and bmi < 20 kg/m2). conditions that confound interpretation of respiratory symptoms. (i.e ventilator dependent, receiving more that 2-3 liters/min of oxygen by nasal cannula, chronic diarrhea, recurrent infections).

brief interview of mental status (bims) score <8 (indicating severe dementia). prior vaccination with the shingrix. positive test for covid 19 or prior history of covid 19 infection. conditions that confound the interpretation of the innate immune measures. (i.e. terminal condition, receiving hospice, stage 3 and 4 open wound, chemotherapy, immune modulators or other immunosuppressants, autoimmune disorders, and bmi < 20 kg/m2). conditions that confound interpretation of respiratory symptoms. (i.e ventilator dependent, receiving more that 2-3 liters/min of oxygen by nasal cannula, chronic diarrhea, recurrent infections).

1. brief interview of mental status (bims) score <8 (indicating severe dementia). 2. prior vaccination with the shingrix. 3. positive test for covid 19 or prior history of covid 19 infection. 4. conditions that confound the interpretation of the innate immune measures. (i.e. terminal condition, receiving hospice, stage 3 and 4 open wound, chemotherapy, immune modulators or other immunosuppressants, autoimmune disorders, and bmi < 20 kg/m2). 5. conditions that confound interpretation of respiratory symptoms. (i.e ventilator dependent, receiving more that 2-3 liters/min of oxygen by nasal cannula, chronic diarrhea, recurrent infections).

1. brief interview of mental status (bims) score <8 (indicating severe dementia). 2. prior vaccination with the shingrix. 3. positive test for covid 19 or prior history of covid 19 infection. 4. conditions that confound the interpretation of the innate immune measures. (i.e. terminal condition, receiving hospice, stage 3 and 4 open wound, chemotherapy, immune modulators or other immunosuppressants, autoimmune disorders, and bmi < 20 kg/m2). 5. conditions that confound interpretation of respiratory symptoms. (i.e ventilator dependent, receiving more that 2-3 liters/min of oxygen by nasal cannula, chronic diarrhea, recurrent infections).