1. individual who has history of covid-19 or is considered infected within 16 weeks (112 days) prior to administration of investigational product. 2. individual who has received other covid-19 vaccine within 16 weeks (112 days) prior to administration of investigational product. 3. individual who has been in close contact with a covid-19 infected person, or has been classified as a confirmed or suspected covid-19 patient within 14 days prior to administration of investigational product. 4. individual determined to be clinically significantly abnormal by the screening outcome based on laboratory evaluations, electrocardiogram (ecg) and chest x-ray. 5. individual who has ant results of positive to hiv test, hepatitis b test, and hepatitis c test on screening. 6. acute febrile illness with 38°c and above, or any suspected infectious diseases, or symptoms similar to covid-19 (cough, shortness of breathe, chills, myalgia, headache, sore throat, loss of taste/smell, etc.) within 3 days prior to administration of investigational product. 7. any serious medical or psychiatric disease which in opinion of investigator judges unable to participate * respiratory diseases: asthma, chronic obstructive lung disease (copd), active or latent tuberculosis which require medication, or individual who has received treatment due to worsening of the respiratory disease within 5 years prior to administration of investigational product. * serious cardiovascular diseases: congestive heart failure, coronary artery disease, myocardial infarction, uncontrolled hypertension, myocarditis, pericarditis, etc. * neurologic diseases: epilepsy, seizure within 3 years, migraine, stroke, encephalopathy, guillain-barre syndrome, encephalomyelitis, acute transverse myelitis, etc. * malignant cancer diagnosed within the past 5 years (skin basal cell and squamous cell carcinoma are excluded). * immune function disorders including autoimmune hypothyroidism, psoriasis. * auto-immune diseases. * history of dependently administering psychotropic drugs or narcotic painkillers within 24 weeks prior to administration of investigational product, or psychiatric disease or behavioral impairment that, in the opinion of the investigator, could interfere with the participant's ability to participate in the trial. * other hepatobiliary, renal, endocrine, urinary tract, muscular skeletal diseases which the investigator considers clinically significant. 8. history of splenectomy. 9. history of sars-cov or mers-cov infection. 10. known history of allergic or hypersensitivity to the components of investigational product. 11. known history of serious adverse reactions, allergies or hypersensitivity related to vaccination. 12. history of urticaria within 5 years prior to administration of investigational product. 13. individual with history of bleeding diathesis or thrombocytopenia, or history of severe bleeding or bruising after intramuscular or intravenous injection, or is receiving an anticoagulant (those who receive low dose aspirin (less than 100mg/day) are not excluded). 14. individual with hereditary or idiopathic angioneurotic edema. 15. individual with solid organ or bone marrow transplantation. 16. individual who is suspected or with history of substance abuse and alcohol abuse within 24 weeks prior to administration of investigational product. 17. history of sars-cov or mers-cov vaccination. 18. history of licensed drug for covid-19 treatment or prevention aside from covid-19 vaccine within 52 weeks prior to administration of investigational product. 19. use of immunosuppressive or chronic use of systemic steroids within 6 weeks prior to administration of investigational product (external steroids, nasal spray and inhalants are allowed). * immunosuppressive: azathioprine, cyclosporine, interferon, g-csf, tacrolimus, everolimus, sirolimus, cyclophosphamide, 6-mercaptopurine, methotrexate, rapamycin, leflunomide, etc. * chronic steroid: \>10 mg/day prednisone equivalent for periods exceeding 14 days) 20. individuals who has administered other investigational product or device within 24 weeks prior to screening visit. 21. individual concomitantly enrolled or scheduled to be enrolled in another trial (including follow-up period). 22. individual vaccinated or planned vaccination within 28 days prior and after the administration of investigational product. 23. receipt of immunoglobulin or blood-derived products within 12 weeks prior to administration of investigational product. 24. individual with scheduled surgery during the study period. 25. pregnant or lactating women. 26. individual directly related to the investigator and meets the following conditions: * personnel relationship or subordinate-superior relationship (employees of the investigator's department, staffs of this trial) * students or researchers in the immediate department of the school to which the investigator belongs (e.g., medical university) 27. individual who is unfit for this study for any other reason in judgement of investigator.

1. individual who has history of covid-19 or is considered infected within 16 weeks (112 days) prior to administration of investigational product. 2. individual who has received other covid-19 vaccine within 16 weeks (112 days) prior to administration of investigational product. 3. individual who has been in close contact with a covid-19 infected person, or has been classified as a confirmed or suspected covid-19 patient within 14 days prior to administration of investigational product. 4. individual determined to be clinically significantly abnormal by the screening outcome based on laboratory evaluations, electrocardiogram (ecg) and chest x-ray. 5. individual who has ant results of positive to hiv test, hepatitis b test, and hepatitis c test on screening. 6. acute febrile illness with 38°c and above, or any suspected infectious diseases, or symptoms similar to covid-19 (cough, shortness of breathe, chills, myalgia, headache, sore throat, loss of taste/smell, etc.) within 3 days prior to administration of investigational product. 7. any serious medical or psychiatric disease which in opinion of investigator judges unable to participate * respiratory diseases: asthma, chronic obstructive lung disease (copd), active or latent tuberculosis which require medication, or individual who has received treatment due to worsening of the respiratory disease within 5 years prior to administration of investigational product. * serious cardiovascular diseases: congestive heart failure, coronary artery disease, myocardial infarction, uncontrolled hypertension, myocarditis, pericarditis, etc. * neurologic diseases: epilepsy, seizure within 3 years, migraine, stroke, encephalopathy, guillain-barre syndrome, encephalomyelitis, acute transverse myelitis, etc. * malignant cancer diagnosed within the past 5 years (skin basal cell and squamous cell carcinoma are excluded). * immune function disorders including autoimmune hypothyroidism, psoriasis. * auto-immune diseases. * history of dependently administering psychotropic drugs or narcotic painkillers within 24 weeks prior to administration of investigational product, or psychiatric disease or behavioral impairment that, in the opinion of the investigator, could interfere with the participant's ability to participate in the trial. * other hepatobiliary, renal, endocrine, urinary tract, muscular skeletal diseases which the investigator considers clinically significant. 8. history of splenectomy. 9. history of sars-cov or mers-cov infection. 10. known history of allergic or hypersensitivity to the components of investigational product. 11. known history of serious adverse reactions, allergies or hypersensitivity related to vaccination. 12. history of urticaria within 5 years prior to administration of investigational product. 13. individual with history of bleeding diathesis or thrombocytopenia, or history of severe bleeding or bruising after intramuscular or intravenous injection, or is receiving an anticoagulant (those who receive low dose aspirin (less than 100mg/day) are not excluded). 14. individual with hereditary or idiopathic angioneurotic edema. 15. individual with solid organ or bone marrow transplantation. 16. individual who is suspected or with history of substance abuse and alcohol abuse within 24 weeks prior to administration of investigational product. 17. history of sars-cov or mers-cov vaccination. 18. history of licensed drug for covid-19 treatment or prevention aside from covid-19 vaccine within 52 weeks prior to administration of investigational product. 19. use of immunosuppressive or chronic use of systemic steroids within 6 weeks prior to administration of investigational product (external steroids, nasal spray and inhalants are allowed). * immunosuppressive: azathioprine, cyclosporine, interferon, g-csf, tacrolimus, everolimus, sirolimus, cyclophosphamide, 6-mercaptopurine, methotrexate, rapamycin, leflunomide, etc. * chronic steroid: \>10 mg/day prednisone equivalent for periods exceeding 14 days) 20. individuals who has administered other investigational product or device within 24 weeks prior to screening visit. 21. individual concomitantly enrolled or scheduled to be enrolled in another trial (including follow-up period). 22. individual vaccinated or planned vaccination within 28 days prior and after the administration of investigational product. 23. receipt of immunoglobulin or blood-derived products within 12 weeks prior to administration of investigational product. 24. individual with scheduled surgery during the study period. 25. pregnant or lactating women. 26. individual directly related to the investigator and meets the following conditions: * personnel relationship or subordinate-superior relationship (employees of the investigator's department, staffs of this trial) * students or researchers in the immediate department of the school to which the investigator belongs (e.g., medical university) 27. individual who is unfit for this study for any other reason in judgement of investigator.

individual who has history of covid-19 or is considered infected within 16 weeks (112 days) prior to administration of investigational product. individual who has received other covid-19 vaccine within 16 weeks (112 days) prior to administration of investigational product. individual who has been in close contact with a covid-19 infected person, or has been classified as a confirmed or suspected covid-19 patient within 14 days prior to administration of investigational product. individual determined to be clinically significantly abnormal by the screening outcome based on laboratory evaluations, electrocardiogram (ecg) and chest x-ray. individual who has ant results of positive to hiv test, hepatitis b test, and hepatitis c test on screening. acute febrile illness with 38°c and above, or any suspected infectious diseases, or symptoms similar to covid-19 (cough, shortness of breathe, chills, myalgia, headache, sore throat, loss of taste/smell, etc.) within 3 days prior to administration of investigational product. any serious medical or psychiatric disease which in opinion of investigator judges unable to participate respiratory diseases: asthma, chronic obstructive lung disease (copd), active or latent tuberculosis which require medication, or individual who has received treatment due to worsening of the respiratory disease within 5 years prior to administration of investigational product. serious cardiovascular diseases: congestive heart failure, coronary artery disease, myocardial infarction, uncontrolled hypertension, myocarditis, pericarditis, etc. neurologic diseases: epilepsy, seizure within 3 years, migraine, stroke, encephalopathy, guillain-barre syndrome, encephalomyelitis, acute transverse myelitis, etc. malignant cancer diagnosed within the past 5 years (skin basal cell and squamous cell carcinoma are excluded). immune function disorders including autoimmune hypothyroidism, psoriasis. auto-immune diseases. history of dependently administering psychotropic drugs or narcotic painkillers within 24 weeks prior to administration of investigational product, or psychiatric disease or behavioral impairment that, in the opinion of the investigator, could interfere with the participant's ability to participate in the trial. other hepatobiliary, renal, endocrine, urinary tract, muscular skeletal diseases which the investigator considers clinically significant. history of splenectomy. history of sars-cov or mers-cov infection. known history of allergic or hypersensitivity to the components of investigational product. known history of serious adverse reactions, allergies or hypersensitivity related to vaccination. history of urticaria within 5 years prior to administration of investigational product. individual with history of bleeding diathesis or thrombocytopenia, or history of severe bleeding or bruising after intramuscular or intravenous injection, or is receiving an anticoagulant (those who receive low dose aspirin (less than 100mg/day) are not excluded). individual with hereditary or idiopathic angioneurotic edema. individual with solid organ or bone marrow transplantation. individual who is suspected or with history of substance abuse and alcohol abuse within 24 weeks prior to administration of investigational product. history of sars-cov or mers-cov vaccination. history of licensed drug for covid-19 treatment or prevention aside from covid-19 vaccine within 52 weeks prior to administration of investigational product. use of immunosuppressive or chronic use of systemic steroids within 6 weeks prior to administration of investigational product (external steroids, nasal spray and inhalants are allowed). immunosuppressive: azathioprine, cyclosporine, interferon, g-csf, tacrolimus, everolimus, sirolimus, cyclophosphamide, 6-mercaptopurine, methotrexate, rapamycin, leflunomide, etc. chronic steroid: >10 mg/day prednisone equivalent for periods exceeding 14 days) individuals who has administered other investigational product or device within 24 weeks prior to screening visit. individual concomitantly enrolled or scheduled to be enrolled in another trial (including follow-up period). individual vaccinated or planned vaccination within 28 days prior and after the administration of investigational product. receipt of immunoglobulin or blood-derived products within 12 weeks prior to administration of investigational product. individual with scheduled surgery during the study period. pregnant or lactating women. individual directly related to the investigator and meets the following conditions: personnel relationship or subordinate-superior relationship (employees of the investigator's department, staffs of this trial) students or researchers in the immediate department of the school to which the investigator belongs (e.g., medical university) individual who is unfit for this study for any other reason in judgement of investigator.

individual who has history of covid-19 or is considered infected within 16 weeks (112 days) prior to administration of investigational product. individual who has received other covid-19 vaccine within 16 weeks (112 days) prior to administration of investigational product. individual who has been in close contact with a covid-19 infected person, or has been classified as a confirmed or suspected covid-19 patient within 14 days prior to administration of investigational product. individual determined to be clinically significantly abnormal by the screening outcome based on laboratory evaluations, electrocardiogram (ecg) and chest x-ray. individual who has ant results of positive to hiv test, hepatitis b test, and hepatitis c test on screening. acute febrile illness with 38°c and above, or any suspected infectious diseases, or symptoms similar to covid-19 (cough, shortness of breathe, chills, myalgia, headache, sore throat, loss of taste/smell, etc.) within 3 days prior to administration of investigational product. any serious medical or psychiatric disease which in opinion of investigator judges unable to participate respiratory diseases: asthma, chronic obstructive lung disease (copd), active or latent tuberculosis which require medication, or individual who has received treatment due to worsening of the respiratory disease within 5 years prior to administration of investigational product. serious cardiovascular diseases: congestive heart failure, coronary artery disease, myocardial infarction, uncontrolled hypertension, myocarditis, pericarditis, etc. neurologic diseases: epilepsy, seizure within 3 years, migraine, stroke, encephalopathy, guillain-barre syndrome, encephalomyelitis, acute transverse myelitis, etc. malignant cancer diagnosed within the past 5 years (skin basal cell and squamous cell carcinoma are excluded). immune function disorders including autoimmune hypothyroidism, psoriasis. auto-immune diseases. history of dependently administering psychotropic drugs or narcotic painkillers within 24 weeks prior to administration of investigational product, or psychiatric disease or behavioral impairment that, in the opinion of the investigator, could interfere with the participant's ability to participate in the trial. other hepatobiliary, renal, endocrine, urinary tract, muscular skeletal diseases which the investigator considers clinically significant. history of splenectomy. history of sars-cov or mers-cov infection. known history of allergic or hypersensitivity to the components of investigational product. known history of serious adverse reactions, allergies or hypersensitivity related to vaccination. history of urticaria within 5 years prior to administration of investigational product. individual with history of bleeding diathesis or thrombocytopenia, or history of severe bleeding or bruising after intramuscular or intravenous injection, or is receiving an anticoagulant (those who receive low dose aspirin (less than 100mg/day) are not excluded). individual with hereditary or idiopathic angioneurotic edema. individual with solid organ or bone marrow transplantation. individual who is suspected or with history of substance abuse and alcohol abuse within 24 weeks prior to administration of investigational product. history of sars-cov or mers-cov vaccination. history of licensed drug for covid-19 treatment or prevention aside from covid-19 vaccine within 52 weeks prior to administration of investigational product. use of immunosuppressive or chronic use of systemic steroids within 6 weeks prior to administration of investigational product (external steroids, nasal spray and inhalants are allowed). immunosuppressive: azathioprine, cyclosporine, interferon, g-csf, tacrolimus, everolimus, sirolimus, cyclophosphamide, 6-mercaptopurine, methotrexate, rapamycin, leflunomide, etc. chronic steroid: >10 mg/day prednisone equivalent for periods exceeding 14 days) individuals who has administered other investigational product or device within 24 weeks prior to screening visit. individual concomitantly enrolled or scheduled to be enrolled in another trial (including follow-up period). individual vaccinated or planned vaccination within 28 days prior and after the administration of investigational product. receipt of immunoglobulin or blood-derived products within 12 weeks prior to administration of investigational product. individual with scheduled surgery during the study period. pregnant or lactating women. individual directly related to the investigator and meets the following conditions: personnel relationship or subordinate-superior relationship (employees of the investigator's department, staffs of this trial) students or researchers in the immediate department of the school to which the investigator belongs (e.g., medical university) individual who is unfit for this study for any other reason in judgement of investigator.

individual who has history of covid-19 or is considered infected within 16 weeks (112 days) prior to administration of investigational product. individual who has received other covid-19 vaccine within 16 weeks (112 days) prior to administration of investigational product. individual who has been in close contact with a covid-19 infected person, or has been classified as a confirmed or suspected covid-19 patient within 14 days prior to administration of investigational product. individual determined to be clinically significantly abnormal by the screening outcome based on laboratory evaluations, electrocardiogram (ecg) and chest x-ray. individual who has ant results of positive to hiv test, hepatitis b test, and hepatitis c test on screening. acute febrile illness with 38°c and above, or any suspected infectious diseases, or symptoms similar to covid-19 (cough, shortness of breathe, chills, myalgia, headache, sore throat, loss of teaste/smell, etc.) within 3 days prior to administration of investigational product. any serious medical or psychiatric disease which in opinion of investigator judges unable to participate respiratory diseases: asthma, chronic obstructive lung disease (copd), active or latent tuberculosis which require medication, or individual who has received treatment due to worsening of the respiratory disease within 5 years prior to administration of investigational product. serious cardiovascular diseases: congestive heart failure, coronary artery disease, myocardial infarction, uncontrolled hypertension, myocarditis, pericarditis, etc. neurologic diseases: epilepsy, seizure within 3 years, migraine, stroke, encephalopathy, guillain-barre syndrome, encephalomyelitis, acute transverse myelitis, etc. malignant cancer diagnosed within the past 5 years (skin basal cell and squamous cell carcinoma are excluded). immune function disorders including autoimmune hypothyroidism, psoriasis. auto-immune diseases. history of dependently administering psychotropic drugs or narcotic painkillers within 24 weeks prior to administration of investigational product, or psychiatric disease or behavioral impairment that, in the opinion of the investigator, could interfere with the participant's ability to participate in the trial. other hepatobiliary, renal, endocrine, urinary tract, muscular skeletal diseases which the investigator considers clinically significant. history of splenectomy. history of sars-cov or mers-cov infection. known history of allergic or hypersensitivity to the components of investigational product. known history of serious adverse reactions, allergies or hypersensitivity related to vaccination. kistory of urticaria within 5 years prior to administration of investigational product. individual with history of bleeding diathesis or thrombocytopenia, or history of severe bleeding or bruising after intramuscular or intravenous injection, or is receiving an anticoagulant (those who receive low dose aspirin (less than 100mg/day) are not excluded). individual with hereditary or idiopathic angioneurotic edema. individual with solid organ or bone marrow transplantation. individual who is suspected or with history of substance abuse and alcohol abuse within 24 weeks prior to administration of investigational product. history of sars-cov or mers-cov vaccination. history of licensed drug for covid-19 treatment or prevention aside from covid-19 vaccine within 52 weeks prior to administration of investigational product. use of immunosuppressive or chronic use of systemic steriods within 6 weeks prior to administration of investigational product (external steroids, nasal spray and inhalants are allowed). immunosuppressive: azathioprine, cyclosporine, interferon, g-csf, tacrolimus, everolimus, sirolimus, cyclophosphamide, 6-mercaptopurine, methotrexate, rapamycin, leflunomide, etc. chronic steroid: >10 mg/day prednisone equivalent for periods exceeding 14 days) individuals who has administered other investigational product or device within 24 weeks prior to screening visit. individual concomitantly enrolled or scheduled to be enrolled in another trial (including follow-up period). individual vaccinated or planned vaccination within 28 days prior and after the administration of investigational product. receipt of immunoglobulin or blood-derived products within 12 weeks prior to administration of investigational product. individual with scheduled surgery during the study period. pregnant or lactating women. individual directly related to the investigator and meets the following conditions: personnel relationship or subordinate-superior relationship (employees of the investigator's department, staffs of this trial) students or researchers in the immediate department of the school to which the investigator belongs (e.g., medical university) individual who is unfit for this study for any other reason in judgement of investigator.

individual who has history of covid-19 or is considered infected within 16 weeks (112 days) prior to administration of investigational product. individual who has received other covid-19 vaccine within 16 weeks (112 days) prior to administration of investigational product. individual who has been in close contact with a covid-19 infected person, or has been classified as a confirmed or suspected covid-19 patient within 14 days prior to administration of investigational product. individual determined to be clinically significantly abnormal by the screening outcome based on laboratory evaluations, electrocardiogram (ecg) and chest x-ray. individual who has ant results of positive to hiv test, hepatitis b test, and hepatitis c test on screening. acute febrile illness with 38°c and above, or any suspected infectious diseases, or symptoms similar to covid-19 (cough, shortness of breathe, chills, myalgia, headache, sore throat, loss of teaste/smell, etc.) within 3 days prior to administration of investigational product. any serious medical or psychiatric disease which in opinion of investigator judges unable to participate respiratory diseases: asthma, chronic obstructive lung disease (copd), active or latent tuberculosis which require medication, or individual who has received treatment due to worsening of the respiratory disease within 5 years prior to administration of investigational product. serious cardiovascular diseases: congestive heart failure, coronary artery disease, myocardial infarction, uncontrolled hypertension, myocarditis, pericarditis, etc. neurologic diseases: epilepsy, seizure within 3 years, migraine, stroke, encephalopathy, guillain-barre syndrome, encephalomyelitis, acute transverse myelitis, etc. malignant cancer diagnosed within the past 5 years (skin basal cell and squamous cell carcinoma are excluded). immune function disorders including autoimmune hypothyroidism, psoriasis. auto-immune diseases. history of dependently administering psychotropic drugs or narcotic painkillers within 24 weeks prior to administration of investigational product, or psychiatric disease or behavioral impairment that, in the opinion of the investigator, could interfere with the participant's ability to participate in the trial. other hepatobiliary, renal, endocrine, urinary tract, muscular skeletal diseases which the investigator considers clinically significant. history of splenectomy. history of sars-cov or mers-cov infection. known history of allergic or hypersensitivity to the components of investigational product. known history of serious adverse reactions, allergies or hypersensitivity related to vaccination. kistory of urticaria within 5 years prior to administration of investigational product. individual with history of bleeding diathesis or thrombocytopenia, or history of severe bleeding or bruising after intramuscular or intravenous injection, or is receiving an anticoagulant (those who receive low dose aspirin (less than 100mg/day) are not excluded). individual with hereditary or idiopathic angioneurotic edema. individual with solid organ or bone marrow transplantation. individual who is suspected or with history of substance abuse and alcohol abuse within 24 weeks prior to administration of investigational product. history of sars-cov or mers-cov vaccination. history of licensed drug for covid-19 treatment or prevention aside from covid-19 vaccine within 52 weeks prior to administration of investigational product. use of immunosuppressive or chronic use of systemic steriods within 6 weeks prior to administration of investigational product (external steroids, nasal spray and inhalants are allowed). immunosuppressive: azathioprine, cyclosporine, interferon, g-csf, tacrolimus, everolimus, sirolimus, cyclophosphamide, 6-mercaptopurine, methotrexate, rapamycin, leflunomide, etc. chronic steroid: >10 mg/day prednisone equivalent for periods exceeding 14 days) individuals who has administered other investigational product or device within 24 weeks prior to screening visit. individual concomitantly enrolled or scheduled to be enrolled in another trial (including follow-up period). individual vaccinated or planned vaccination within 28 days prior and after the administration of investigational product. receipt of immunoglobulin or blood-derived products within 12 weeks prior to administration of investigational product. individual with scheduled surgery during the study period. pregnant or lactating women. individual directly related to the investigator and meets the following conditions: personnel relationship or subordinate-superior relationship (employees of the investigator's department, staffs of this trial) students or researchers in the immediate department of the school to which the investigator belongs (e.g., medical university) individual who is unfit for this study for any other reason in judgement of investigator.