* refusal to participate expressed by patient or legally authorized representative if they are present * patients using drugs with potential interaction with lopinavir/ritonavir or interferon-β 1a * pregnant or lactating women. * history of alcohol or drug addiction in the past 5 years. * blood alt/ast levels \> 5 times the upper limit of normal on laboratory results. * the patients who were intubated less than one hours after admission to the hospital

* refusal to participate expressed by patient or legally authorized representative if they are present * patients using drugs with potential interaction with lopinavir/ritonavir or interferon-β 1a * pregnant or lactating women. * history of alcohol or drug addiction in the past 5 years. * blood alt/ast levels \> 5 times the upper limit of normal on laboratory results. * the patients who were intubated less than one hours after admission to the hospital

- refusal to participate expressed by patient or legally authorized representative if they are present - patients using drugs with potential interaction with lopinavir/ritonavir or interferon-β 1a - pregnant or lactating women. - history of alcohol or drug addiction in the past 5 years. - blood alt/ast levels > 5 times the upper limit of normal on laboratory results. - the patients who were intubated less than one hours after admission to the hospital

- refusal to participate expressed by patient or legally authorized representative if they are present - patients using drugs with potential interaction with lopinavir/ritonavir or interferon-β 1a - pregnant or lactating women. - history of alcohol or drug addiction in the past 5 years. - blood alt/ast levels > 5 times the upper limit of normal on laboratory results. - the patients who were intubated less than one hours after admission to the hospital