inclusion criteria: * age ≥ 18 years at the time informed consent is obtained * positive for sars-cov-2 infection determined by a diagnostic test approved by the food and drug administration (fda) or allowed under an emergency use authorization * chest computed tomography (ct) scan or x ray results confirming interstitial pneumonia * meets ≥ 1 of the following criteria (subjects improving while on respiratory support still qualify): * respiratory rate \> 30 breaths per minute * peripheral (capillary) oxygen saturation (spo2) ≤ 93% on room air * partial pressure of oxygen in arterial blood (pao2) to fraction of inspired oxygen (fio2) ratio (pao2 / fio2) \< 300 * spo2 / fio2 ratio \< 218 (if pao2 / fio2 ratio is not available) * radiographic lung infiltrates \> 50%

inclusion criteria: * age ≥ 18 years at the time informed consent is obtained * positive for sars-cov-2 infection determined by a diagnostic test approved by the food and drug administration (fda) or allowed under an emergency use authorization * chest computed tomography (ct) scan or x ray results confirming interstitial pneumonia * meets ≥ 1 of the following criteria (subjects improving while on respiratory support still qualify): * respiratory rate \> 30 breaths per minute * peripheral (capillary) oxygen saturation (spo2) ≤ 93% on room air * partial pressure of oxygen in arterial blood (pao2) to fraction of inspired oxygen (fio2) ratio (pao2 / fio2) \< 300 * spo2 / fio2 ratio \< 218 (if pao2 / fio2 ratio is not available) * radiographic lung infiltrates \> 50%

inclusion criteria: - age ≥ 18 years at the time informed consent is obtained - positive for sars-cov-2 infection determined by a diagnostic test approved by the food and drug administration (fda) or allowed under an emergency use authorization - chest computed tomography (ct) scan or x ray results confirming interstitial pneumonia - meets ≥ 1 of the following criteria (subjects improving while on respiratory support still qualify): - respiratory rate > 30 breaths per minute - peripheral (capillary) oxygen saturation (spo2) ≤ 93% on room air - partial pressure of oxygen in arterial blood (pao2) to fraction of inspired oxygen (fio2) ratio (pao2 / fio2) < 300 - spo2 / fio2 ratio < 218 (if pao2 / fio2 ratio is not available) - radiographic lung infiltrates > 50%

inclusion criteria: - age ≥ 18 years at the time informed consent is obtained - positive for sars-cov-2 infection determined by a diagnostic test approved by the food and drug administration (fda) or allowed under an emergency use authorization - chest computed tomography (ct) scan or x ray results confirming interstitial pneumonia - meets ≥ 1 of the following criteria (subjects improving while on respiratory support still qualify): - respiratory rate > 30 breaths per minute - peripheral (capillary) oxygen saturation (spo2) ≤ 93% on room air - partial pressure of oxygen in arterial blood (pao2) to fraction of inspired oxygen (fio2) ratio (pao2 / fio2) < 300 - spo2 / fio2 ratio < 218 (if pao2 / fio2 ratio is not available) - radiographic lung infiltrates > 50%