1. individuals who are antigen positive, seropositive or reverse transcriptase polymerase chain reaction (rt-pcr) positive for sarscov-2. 2. women currently pregnant, lactating, or planning a pregnancy within 3 months post boost vaccine. 3. any medically diagnosed or suspected immunosuppressive or immunodeficient condition based on medical history and physical examination including known infection with human immunodeficiency virus (hiv), hepatitis b virus (hbv) or hepatitis c virus (hcv). 4. receipt of an organ or bone marrow transplant; or long-term (\>2 weeks) use of oral or parenteral steroids or high-dose inhaled steroids (\>800 μg/day of beclomethasone dipropionate or equivalent) within 6 months before screening (nasal and topical steroids are allowed). 5. history of guillain-barré syndrome or any degenerative neurology disorder, or myocarditis, pericarditis. 6. history of anaphylactic-type reaction to any injected vaccines; or known or suspected hypersensitivity to 1 or more of the components of the vaccine. 7. acute illness or fever (axillary temperature ≥ 37.5ºc or oral temperature ≥ 38.0ºc) within 3 days (72 hours) before study enrollment (enrollment may be delayed for full recovery if acceptable to the investigator). 8. congenital or functional absence of spleen, complete or partial removal of spleen in any case. 9. donate or loss ≥ 450 ml of blood within 1 month prior to enrollment or expected blood donation during the study. 10. individuals currently participating or planning to participate in a study that involves an experimental agent (vaccine, drug, biologic, device, or medication); or who have received an experimental agent within 1 month (3 months for immunoglobulins) before enrollment in this study; or who expect to receive another experimental agent during participation in this study. 11. receipt of immunoglobulin or another blood product within the 3 months before enrollment in this study or those who expect to receive immunoglobulin or another blood product during this study. 12. ineligible for the study based on the assessment of investigator. 13. suspected or known current alcohol or drug dependency within 12 months of screening. 14. individuals who are using medications with the intention of covid-19 prophylaxis and who received or voluntarily plan to receive any other covid-19 booster vaccine other than the study vaccines. 15. history of surgery or major trauma within 12 weeks of screening, or surgery planned during the study. 16. received influenza vaccination within 14 days prior to study vaccination, or any other vaccine within 30 days prior to study vaccination. 17. current diagnosis of or treatment for cancer (except basal cell carcinoma of the skin and cervical carcinoma in situ) 18. bleeding disorder (e.g., factor deficiency, coagulopathy or platelet disorder), or prior history of significant bleeding or bruising following im injections or venipuncture. 19. continuous use of anticoagulants, such as coumarins and related anticoagulants (i.e., warfarin) or novel oral anticoagulants (i.e., apixaban, rivaroxaban, dabigatran and edoxaban). 20. history of heparin-induced thrombocytopenia and thrombosis (hitt or hit type 2) or cerebral venous sinus thrombosis, increased risk for cerebrovascular venous and sinus thrombosis, history of immune thrombocytopenia, or a history of capillary leak syndrome.

1. individuals who are antigen positive, seropositive or reverse transcriptase polymerase chain reaction (rt-pcr) positive for sarscov-2. 2. women currently pregnant, lactating, or planning a pregnancy within 3 months post boost vaccine. 3. any medically diagnosed or suspected immunosuppressive or immunodeficient condition based on medical history and physical examination including known infection with human immunodeficiency virus (hiv), hepatitis b virus (hbv) or hepatitis c virus (hcv). 4. receipt of an organ or bone marrow transplant; or long-term (\>2 weeks) use of oral or parenteral steroids or high-dose inhaled steroids (\>800 μg/day of beclomethasone dipropionate or equivalent) within 6 months before screening (nasal and topical steroids are allowed). 5. history of guillain-barré syndrome or any degenerative neurology disorder, or myocarditis, pericarditis. 6. history of anaphylactic-type reaction to any injected vaccines; or known or suspected hypersensitivity to 1 or more of the components of the vaccine. 7. acute illness or fever (axillary temperature ≥ 37.5ºc or oral temperature ≥ 38.0ºc) within 3 days (72 hours) before study enrollment (enrollment may be delayed for full recovery if acceptable to the investigator). 8. congenital or functional absence of spleen, complete or partial removal of spleen in any case. 9. donate or loss ≥ 450 ml of blood within 1 month prior to enrollment or expected blood donation during the study. 10. individuals currently participating or planning to participate in a study that involves an experimental agent (vaccine, drug, biologic, device, or medication); or who have received an experimental agent within 1 month (3 months for immunoglobulins) before enrollment in this study; or who expect to receive another experimental agent during participation in this study. 11. receipt of immunoglobulin or another blood product within the 3 months before enrollment in this study or those who expect to receive immunoglobulin or another blood product during this study. 12. ineligible for the study based on the assessment of investigator. 13. suspected or known current alcohol or drug dependency within 12 months of screening. 14. individuals who are using medications with the intention of covid-19 prophylaxis and who received or voluntarily plan to receive any other covid-19 booster vaccine other than the study vaccines. 15. history of surgery or major trauma within 12 weeks of screening, or surgery planned during the study. 16. received influenza vaccination within 14 days prior to study vaccination, or any other vaccine within 30 days prior to study vaccination. 17. current diagnosis of or treatment for cancer (except basal cell carcinoma of the skin and cervical carcinoma in situ) 18. bleeding disorder (e.g., factor deficiency, coagulopathy or platelet disorder), or prior history of significant bleeding or bruising following im injections or venipuncture. 19. continuous use of anticoagulants, such as coumarins and related anticoagulants (i.e., warfarin) or novel oral anticoagulants (i.e., apixaban, rivaroxaban, dabigatran and edoxaban). 20. history of heparin-induced thrombocytopenia and thrombosis (hitt or hit type 2) or cerebral venous sinus thrombosis, increased risk for cerebrovascular venous and sinus thrombosis, history of immune thrombocytopenia, or a history of capillary leak syndrome.

individuals who are antigen positive, seropositive or reverse transcriptase polymerase chain reaction (rt-pcr) positive for sarscov-2. women currently pregnant, lactating, or planning a pregnancy within 3 months post boost vaccine. any medically diagnosed or suspected immunosuppressive or immunodeficient condition based on medical history and physical examination including known infection with human immunodeficiency virus (hiv), hepatitis b virus (hbv) or hepatitis c virus (hcv). receipt of an organ or bone marrow transplant; or long-term (>2 weeks) use of oral or parenteral steroids or high-dose inhaled steroids (>800 μg/day of beclomethasone dipropionate or equivalent) within 6 months before screening (nasal and topical steroids are allowed). history of guillain-barré syndrome or any degenerative neurology disorder, or myocarditis, pericarditis. history of anaphylactic-type reaction to any injected vaccines; or known or suspected hypersensitivity to 1 or more of the components of the vaccine. acute illness or fever (axillary temperature ≥ 37.5ºc or oral temperature ≥ 38.0ºc) within 3 days (72 hours) before study enrollment (enrollment may be delayed for full recovery if acceptable to the investigator). congenital or functional absence of spleen, complete or partial removal of spleen in any case. donate or loss ≥ 450 ml of blood within 1 month prior to enrollment or expected blood donation during the study. individuals currently participating or planning to participate in a study that involves an experimental agent (vaccine, drug, biologic, device, or medication); or who have received an experimental agent within 1 month (3 months for immunoglobulins) before enrollment in this study; or who expect to receive another experimental agent during participation in this study. receipt of immunoglobulin or another blood product within the 3 months before enrollment in this study or those who expect to receive immunoglobulin or another blood product during this study. ineligible for the study based on the assessment of investigator. suspected or known current alcohol or drug dependency within 12 months of screening. individuals who are using medications with the intention of covid-19 prophylaxis and who received or voluntarily plan to receive any other covid-19 booster vaccine other than the study vaccines. history of surgery or major trauma within 12 weeks of screening, or surgery planned during the study. received influenza vaccination within 14 days prior to study vaccination, or any other vaccine within 30 days prior to study vaccination. current diagnosis of or treatment for cancer (except basal cell carcinoma of the skin and cervical carcinoma in situ) bleeding disorder (e.g., factor deficiency, coagulopathy or platelet disorder), or prior history of significant bleeding or bruising following im injections or venipuncture. continuous use of anticoagulants, such as coumarins and related anticoagulants (i.e., warfarin) or novel oral anticoagulants (i.e., apixaban, rivaroxaban, dabigatran and edoxaban). history of heparin-induced thrombocytopenia and thrombosis (hitt or hit type 2) or cerebral venous sinus thrombosis, increased risk for cerebrovascular venous and sinus thrombosis, history of immune thrombocytopenia, or a history of capillary leak syndrome.

individuals who are antigen positive, seropositive or reverse transcriptase polymerase chain reaction (rt-pcr) positive for sarscov-2. women currently pregnant, lactating, or planning a pregnancy within 3 months post boost vaccine. any medically diagnosed or suspected immunosuppressive or immunodeficient condition based on medical history and physical examination including known infection with human immunodeficiency virus (hiv), hepatitis b virus (hbv) or hepatitis c virus (hcv). receipt of an organ or bone marrow transplant; or long-term (>2 weeks) use of oral or parenteral steroids or high-dose inhaled steroids (>800 μg/day of beclomethasone dipropionate or equivalent) within 6 months before screening (nasal and topical steroids are allowed). history of guillain-barré syndrome or any degenerative neurology disorder, or myocarditis, pericarditis. history of anaphylactic-type reaction to any injected vaccines; or known or suspected hypersensitivity to 1 or more of the components of the vaccine. acute illness or fever (axillary temperature ≥ 37.5ºc or oral temperature ≥ 38.0ºc) within 3 days (72 hours) before study enrollment (enrollment may be delayed for full recovery if acceptable to the investigator). congenital or functional absence of spleen, complete or partial removal of spleen in any case. donate or loss ≥ 450 ml of blood within 1 month prior to enrollment or expected blood donation during the study. individuals currently participating or planning to participate in a study that involves an experimental agent (vaccine, drug, biologic, device, or medication); or who have received an experimental agent within 1 month (3 months for immunoglobulins) before enrollment in this study; or who expect to receive another experimental agent during participation in this study. receipt of immunoglobulin or another blood product within the 3 months before enrollment in this study or those who expect to receive immunoglobulin or another blood product during this study. ineligible for the study based on the assessment of investigator. suspected or known current alcohol or drug dependency within 12 months of screening. individuals who are using medications with the intention of covid-19 prophylaxis and who received or voluntarily plan to receive any other covid-19 booster vaccine other than the study vaccines. history of surgery or major trauma within 12 weeks of screening, or surgery planned during the study. received influenza vaccination within 14 days prior to study vaccination, or any other vaccine within 30 days prior to study vaccination. current diagnosis of or treatment for cancer (except basal cell carcinoma of the skin and cervical carcinoma in situ) bleeding disorder (e.g., factor deficiency, coagulopathy or platelet disorder), or prior history of significant bleeding or bruising following im injections or venipuncture. continuous use of anticoagulants, such as coumarins and related anticoagulants (i.e., warfarin) or novel oral anticoagulants (i.e., apixaban, rivaroxaban, dabigatran and edoxaban). history of heparin-induced thrombocytopenia and thrombosis (hitt or hit type 2) or cerebral venous sinus thrombosis, increased risk for cerebrovascular venous and sinus thrombosis, history of immune thrombocytopenia, or a history of capillary leak syndrome.