main inclusion criteria: 1. written informed consent. 2. hospitalized, adult (≥ 18 years of age) subjects. 3. diagnosis of cap or covid- 19 pneumonia (e.g. according to local guidelines) and with radiologic evidence showing new pulmonary lobar or multilobar infiltrates consistent with cap or covid-19 pneumonia. 4. receiving oxygen supply via low-flow oxygen, high-flow oxygen or on non-invasive ventilation. 5. fulfilling at least one clinical respiratory parameter (spo2 ≤ 94% and/or 100 mm hg \< pao2/fio2 ≤ 300 mm hg). 6. signs of early systemic inflammation based on crp and coagulation parameter threshold levels. main

main inclusion criteria: 1. written informed consent. 2. hospitalized, adult (≥ 18 years of age) subjects. 3. diagnosis of cap or covid- 19 pneumonia (e.g. according to local guidelines) and with radiologic evidence showing new pulmonary lobar or multilobar infiltrates consistent with cap or covid-19 pneumonia. 4. receiving oxygen supply via low-flow oxygen, high-flow oxygen or on non-invasive ventilation. 5. fulfilling at least one clinical respiratory parameter (spo2 ≤ 94% and/or 100 mm hg \< pao2/fio2 ≤ 300 mm hg). 6. signs of early systemic inflammation based on crp and coagulation parameter threshold levels. main

main inclusion criteria: written informed consent. hospitalized, adult (≥ 18 years of age) subjects. diagnosis of cap or covid- 19 pneumonia (e.g. according to local guidelines) and with radiologic evidence showing new pulmonary lobar or multilobar infiltrates consistent with cap or covid-19 pneumonia. receiving oxygen supply via low-flow oxygen, high-flow oxygen or on non-invasive ventilation. fulfilling at least one clinical respiratory parameter (spo2 ≤ 94% and/or 100 mm hg < pao2/fio2 ≤ 300 mm hg). signs of early systemic inflammation based on crp and coagulation parameter threshold levels. main

main inclusion criteria: written informed consent. hospitalized, adult (≥ 18 years of age) subjects. diagnosis of cap or covid- 19 pneumonia (e.g. according to local guidelines) and with radiologic evidence showing new pulmonary lobar or multilobar infiltrates consistent with cap or covid-19 pneumonia. receiving oxygen supply via low-flow oxygen, high-flow oxygen or on non-invasive ventilation. fulfilling at least one clinical respiratory parameter (spo2 ≤ 94% and/or 100 mm hg < pao2/fio2 ≤ 300 mm hg). signs of early systemic inflammation based on crp and coagulation parameter threshold levels. main

main inclusion criteria: written informed consent. hospitalized, adult (≥ 18 years of age) subjects. laboratory-confirmed acute severe acute respiratory syndrome coronavirus 2 (sars-cov-2) infection. receiving oxygen supply via low-flow or high-flow oxygen or on non-invasive ventilation. fulfilling at least one clinical respiratory parameter (spo2 ≤ 94% and/or 100 mm hg < pao2/fio2 ≤ 300 mm hg and/or radiologic evidence of covid-19 pneumonia) signs of early systemic inflammation based on crp and coagulation parameter threshold levels. main

main inclusion criteria: written informed consent. hospitalized, adult (≥ 18 years of age) subjects. laboratory-confirmed acute severe acute respiratory syndrome coronavirus 2 (sars-cov-2) infection. receiving oxygen supply via low-flow or high-flow oxygen or on non-invasive ventilation. fulfilling at least one clinical respiratory parameter (spo2 ≤ 94% and/or 100 mm hg < pao2/fio2 ≤ 300 mm hg and/or radiologic evidence of covid-19 pneumonia) signs of early systemic inflammation based on crp and coagulation parameter threshold levels. main