inclusion criteria: i-1 healthy volunteers of both sexes aged 18-59 years i-2 able to give signed informed consent, i-3 will be able to comply with the study protocol for approximately 6 months (depending on the group), i-4 hiv, hepatitis b and c tests are negative, i-5 body temperature below 37.2oc i-6 covid-19 igg and igm antibodies negative and no history of symptomatic disease, i-7 those who have not previously received any covid-19 vaccines i-8 negative qpcr sars-cov-2 result in nasopharynx or sputum samples, i-9 body mass index between 18-35 kg/m2, i-10 abnormal finding in complete blood count, alanine aminotransferase (alt), aspartate aminotransferase (ast), total bilirubin, urea, creatinine and fasting blood sugar between the normal reference values or detected in any laboratory parameter is grade 1 according to the opinion of the investigator\* volunteers not older (\>grade 1) i-11 good general health (history and physical examination within 14 days prior to enrollment in the study), i-12 if female, healthy volunteers who are not pregnant or who can use appropriate contraception within 30 days before vaccine injection and within 6 months after vaccination will be included in the study. i-13 male volunteers who can use appropriate contraception within 6 months after vaccine injection will be included in the study.

inclusion criteria: i-1 healthy volunteers of both sexes aged 18-59 years i-2 able to give signed informed consent, i-3 will be able to comply with the study protocol for approximately 6 months (depending on the group), i-4 hiv, hepatitis b and c tests are negative, i-5 body temperature below 37.2oc i-6 covid-19 igg and igm antibodies negative and no history of symptomatic disease, i-7 those who have not previously received any covid-19 vaccines i-8 negative qpcr sars-cov-2 result in nasopharynx or sputum samples, i-9 body mass index between 18-35 kg/m2, i-10 abnormal finding in complete blood count, alanine aminotransferase (alt), aspartate aminotransferase (ast), total bilirubin, urea, creatinine and fasting blood sugar between the normal reference values or detected in any laboratory parameter is grade 1 according to the opinion of the investigator\* volunteers not older (\>grade 1) i-11 good general health (history and physical examination within 14 days prior to enrollment in the study), i-12 if female, healthy volunteers who are not pregnant or who can use appropriate contraception within 30 days before vaccine injection and within 6 months after vaccination will be included in the study. i-13 male volunteers who can use appropriate contraception within 6 months after vaccine injection will be included in the study.

inclusion criteria: i-1 healthy volunteers of both sexes aged 18-59 years i-2 able to give signed informed consent, i-3 will be able to comply with the study protocol for approximately 6 months (depending on the group), i-4 hiv, hepatitis b and c tests are negative, i-5 body temperature below 37.2oc i-6 covid-19 igg and igm antibodies negative and no history of symptomatic disease, i-7 those who have not previously received any covid-19 vaccines i-8 negative qpcr sars-cov-2 result in nasopharynx or sputum samples, i-9 body mass index between 18-35 kg/m2, i-10 abnormal finding in complete blood count, alanine aminotransferase (alt), aspartate aminotransferase (ast), total bilirubin, urea, creatinine and fasting blood sugar between the normal reference values or detected in any laboratory parameter is grade 1 according to the opinion of the investigator* volunteers not older (>grade 1) i-11 good general health (history and physical examination within 14 days prior to enrollment in the study), i-12 if female, healthy volunteers who are not pregnant or who can use appropriate contraception within 30 days before vaccine injection and within 6 months after vaccination will be included in the study. i-13 male volunteers who can use appropriate contraception within 6 months after vaccine injection will be included in the study.

inclusion criteria: i-1 healthy volunteers of both sexes aged 18-59 years i-2 able to give signed informed consent, i-3 will be able to comply with the study protocol for approximately 6 months (depending on the group), i-4 hiv, hepatitis b and c tests are negative, i-5 body temperature below 37.2oc i-6 covid-19 igg and igm antibodies negative and no history of symptomatic disease, i-7 those who have not previously received any covid-19 vaccines i-8 negative qpcr sars-cov-2 result in nasopharynx or sputum samples, i-9 body mass index between 18-35 kg/m2, i-10 abnormal finding in complete blood count, alanine aminotransferase (alt), aspartate aminotransferase (ast), total bilirubin, urea, creatinine and fasting blood sugar between the normal reference values or detected in any laboratory parameter is grade 1 according to the opinion of the investigator* volunteers not older (>grade 1) i-11 good general health (history and physical examination within 14 days prior to enrollment in the study), i-12 if female, healthy volunteers who are not pregnant or who can use appropriate contraception within 30 days before vaccine injection and within 6 months after vaccination will be included in the study. i-13 male volunteers who can use appropriate contraception within 6 months after vaccine injection will be included in the study.