Created at Source Raw Value Validated value
June 25, 2024, noon usa

1. hypersensitivity to treamid (active pharmaceutical substance xc268bg) and/or other components of the study drug. 2. history of invasive mechanical ventilation and high-flow oxygenation in the last 45 days or need for oxygen support at screening and randomization. 3. chronic respiratory diseases diagnosed before covid-19, including idiopathic pulmonary fibrosis and other interstitial lung diseases, moderate to severe bronchial asthma, moderate to severe chronic obstructive pulmonary disease, tuberculosis (including suspected tuberculosis based on ct examination at screening) or pulmonary hypertension. 4. severe anemia (haemoglobin \< 70 g/l at screening). 5. inability to perform a ct procedure (for example, a gypsum bandage or metal structures in the study area). 6. severe cardiovascular disease at present or within 6 months prior to screening, including: class iii or iv chronic heart failure (new york heart association classification), clinically significant ventricular arrhythmias (ventricular tachycardia, ventricular fibrillation), unstable angina, myocardial infarction, heart and coronary vessel surgery, significant heart valve disease, uncontrolled hypertension with systolic blood pressure \> 180 mmhg and diastolic blood pressure \> 110 mmhg, pulmonary embolism arteries or deep vein thrombosis. 7. chronic kidney disease or other significant kidney disease with glomerular filtration rate (gfr) \< 60 ml/min (cockcroft-gault formula) at screening. hemodialysis requirement at patient screening. 8. stage ii chronic liver failure (decompensated) and above; history of liver cirrhosis; alanine aminotransferase (alt) and/or aspartate aminotransferase (ast) elevations of 3 or more times the upper limit of normal (uln) at screening; increase in total bilirubin 2 or more times from uln at screening (exception - gilbert's syndrome in the history). 9. severe diseases of the central nervous system, including a history of seizures or conditions that may lead to their development; stroke or transient ischemic attack within 6 months prior to screening; traumatic brain injury or loss of consciousness within 6 months prior to screening; brain tumor. 10. malignancies requiring chemotherapy treatment within 5 years prior to screening or currently suspected cancer. 11. participation in other clinical trials within 1.5 months prior to screening. 12. requirement for or administration of the following drugs for 1 month prior to screening: erythropoietin, cytostatics, colchicine, cyclosporin a, interferon- γ -1b, bosentan, macitentan, etanercept, sildenafil, imatinib, warfarin, ambrisentan, nintedanib, pirfenidone, hyaluronidase asoxime 1 month prior to screening; glucocorticosteroids and n-acetylcysteine (requirement or 7 days prior to screening) 13. lactase deficiency, lactose intolerance, glucose-galactose malabsorption. 14. signs of a marked uncontrolled concomitant disease, such as disorders of the nervous system, kidney, liver, endocrine system and gastrointestinal tract, which, in the opinion of the investigator, could prevent the patient from participating in the study. 15. positive test for human immunodeficiency virus (hiv), hepatitis b and/or c. 16. alcohol or drug addiction, history of mental illness. 17. severe, decompensated or unstable somatic diseases (any diseases or conditions that threaten the patient's life or impair the patient's prognosis, and make it impossible for him to participate in a clinical trial). 18. patient's unwillingness or inability to comply with protocol procedures (in the opinion of the study physician). 19. pregnancy or breastfeeding period. 20. other conditions that, in the opinion of the study physician, prevent the patient from entering the study.

1. hypersensitivity to treamid (active pharmaceutical substance xc268bg) and/or other components of the study drug. 2. history of invasive mechanical ventilation and high-flow oxygenation in the last 45 days or need for oxygen support at screening and randomization. 3. chronic respiratory diseases diagnosed before covid-19, including idiopathic pulmonary fibrosis and other interstitial lung diseases, moderate to severe bronchial asthma, moderate to severe chronic obstructive pulmonary disease, tuberculosis (including suspected tuberculosis based on ct examination at screening) or pulmonary hypertension. 4. severe anemia (haemoglobin \< 70 g/l at screening). 5. inability to perform a ct procedure (for example, a gypsum bandage or metal structures in the study area). 6. severe cardiovascular disease at present or within 6 months prior to screening, including: class iii or iv chronic heart failure (new york heart association classification), clinically significant ventricular arrhythmias (ventricular tachycardia, ventricular fibrillation), unstable angina, myocardial infarction, heart and coronary vessel surgery, significant heart valve disease, uncontrolled hypertension with systolic blood pressure \> 180 mmhg and diastolic blood pressure \> 110 mmhg, pulmonary embolism arteries or deep vein thrombosis. 7. chronic kidney disease or other significant kidney disease with glomerular filtration rate (gfr) \< 60 ml/min (cockcroft-gault formula) at screening. hemodialysis requirement at patient screening. 8. stage ii chronic liver failure (decompensated) and above; history of liver cirrhosis; alanine aminotransferase (alt) and/or aspartate aminotransferase (ast) elevations of 3 or more times the upper limit of normal (uln) at screening; increase in total bilirubin 2 or more times from uln at screening (exception - gilbert's syndrome in the history). 9. severe diseases of the central nervous system, including a history of seizures or conditions that may lead to their development; stroke or transient ischemic attack within 6 months prior to screening; traumatic brain injury or loss of consciousness within 6 months prior to screening; brain tumor. 10. malignancies requiring chemotherapy treatment within 5 years prior to screening or currently suspected cancer. 11. participation in other clinical trials within 1.5 months prior to screening. 12. requirement for or administration of the following drugs for 1 month prior to screening: erythropoietin, cytostatics, colchicine, cyclosporin a, interferon- γ -1b, bosentan, macitentan, etanercept, sildenafil, imatinib, warfarin, ambrisentan, nintedanib, pirfenidone, hyaluronidase asoxime 1 month prior to screening; glucocorticosteroids and n-acetylcysteine (requirement or 7 days prior to screening) 13. lactase deficiency, lactose intolerance, glucose-galactose malabsorption. 14. signs of a marked uncontrolled concomitant disease, such as disorders of the nervous system, kidney, liver, endocrine system and gastrointestinal tract, which, in the opinion of the investigator, could prevent the patient from participating in the study. 15. positive test for human immunodeficiency virus (hiv), hepatitis b and/or c. 16. alcohol or drug addiction, history of mental illness. 17. severe, decompensated or unstable somatic diseases (any diseases or conditions that threaten the patient's life or impair the patient's prognosis, and make it impossible for him to participate in a clinical trial). 18. patient's unwillingness or inability to comply with protocol procedures (in the opinion of the study physician). 19. pregnancy or breastfeeding period. 20. other conditions that, in the opinion of the study physician, prevent the patient from entering the study.

Aug. 26, 2022, 9 p.m. usa

hypersensitivity to treamid (active pharmaceutical substance xc268bg) and/or other components of the study drug. history of invasive mechanical ventilation and high-flow oxygenation in the last 45 days or need for oxygen support at screening and randomization. chronic respiratory diseases diagnosed before covid-19, including idiopathic pulmonary fibrosis and other interstitial lung diseases, moderate to severe bronchial asthma, moderate to severe chronic obstructive pulmonary disease, tuberculosis (including suspected tuberculosis based on ct examination at screening) or pulmonary hypertension. severe anemia (haemoglobin < 70 g/l at screening). inability to perform a ct procedure (for example, a gypsum bandage or metal structures in the study area). severe cardiovascular disease at present or within 6 months prior to screening, including: class iii or iv chronic heart failure (new york heart association classification), clinically significant ventricular arrhythmias (ventricular tachycardia, ventricular fibrillation), unstable angina, myocardial infarction, heart and coronary vessel surgery, significant heart valve disease, uncontrolled hypertension with systolic blood pressure > 180 mmhg and diastolic blood pressure > 110 mmhg, pulmonary embolism arteries or deep vein thrombosis. chronic kidney disease or other significant kidney disease with glomerular filtration rate (gfr) < 60 ml/min (cockcroft-gault formula) at screening. hemodialysis requirement at patient screening. stage ii chronic liver failure (decompensated) and above; history of liver cirrhosis; alanine aminotransferase (alt) and/or aspartate aminotransferase (ast) elevations of 3 or more times the upper limit of normal (uln) at screening; increase in total bilirubin 2 or more times from uln at screening (exception - gilbert's syndrome in the history). severe diseases of the central nervous system, including a history of seizures or conditions that may lead to their development; stroke or transient ischemic attack within 6 months prior to screening; traumatic brain injury or loss of consciousness within 6 months prior to screening; brain tumor. malignancies requiring chemotherapy treatment within 5 years prior to screening or currently suspected cancer. participation in other clinical trials within 1.5 months prior to screening. requirement for or administration of the following drugs for 1 month prior to screening: erythropoietin, cytostatics, colchicine, cyclosporin a, interferon- γ -1b, bosentan, macitentan, etanercept, sildenafil, imatinib, warfarin, ambrisentan, nintedanib, pirfenidone, hyaluronidase asoxime 1 month prior to screening; glucocorticosteroids and n-acetylcysteine (requirement or 7 days prior to screening) lactase deficiency, lactose intolerance, glucose-galactose malabsorption. signs of a marked uncontrolled concomitant disease, such as disorders of the nervous system, kidney, liver, endocrine system and gastrointestinal tract, which, in the opinion of the investigator, could prevent the patient from participating in the study. positive test for human immunodeficiency virus (hiv), hepatitis b and/or c. alcohol or drug addiction, history of mental illness. severe, decompensated or unstable somatic diseases (any diseases or conditions that threaten the patient's life or impair the patient's prognosis, and make it impossible for him to participate in a clinical trial). patient's unwillingness or inability to comply with protocol procedures (in the opinion of the study physician). pregnancy or breastfeeding period. other conditions that, in the opinion of the study physician, prevent the patient from entering the study.

hypersensitivity to treamid (active pharmaceutical substance xc268bg) and/or other components of the study drug. history of invasive mechanical ventilation and high-flow oxygenation in the last 45 days or need for oxygen support at screening and randomization. chronic respiratory diseases diagnosed before covid-19, including idiopathic pulmonary fibrosis and other interstitial lung diseases, moderate to severe bronchial asthma, moderate to severe chronic obstructive pulmonary disease, tuberculosis (including suspected tuberculosis based on ct examination at screening) or pulmonary hypertension. severe anemia (haemoglobin < 70 g/l at screening). inability to perform a ct procedure (for example, a gypsum bandage or metal structures in the study area). severe cardiovascular disease at present or within 6 months prior to screening, including: class iii or iv chronic heart failure (new york heart association classification), clinically significant ventricular arrhythmias (ventricular tachycardia, ventricular fibrillation), unstable angina, myocardial infarction, heart and coronary vessel surgery, significant heart valve disease, uncontrolled hypertension with systolic blood pressure > 180 mmhg and diastolic blood pressure > 110 mmhg, pulmonary embolism arteries or deep vein thrombosis. chronic kidney disease or other significant kidney disease with glomerular filtration rate (gfr) < 60 ml/min (cockcroft-gault formula) at screening. hemodialysis requirement at patient screening. stage ii chronic liver failure (decompensated) and above; history of liver cirrhosis; alanine aminotransferase (alt) and/or aspartate aminotransferase (ast) elevations of 3 or more times the upper limit of normal (uln) at screening; increase in total bilirubin 2 or more times from uln at screening (exception - gilbert's syndrome in the history). severe diseases of the central nervous system, including a history of seizures or conditions that may lead to their development; stroke or transient ischemic attack within 6 months prior to screening; traumatic brain injury or loss of consciousness within 6 months prior to screening; brain tumor. malignancies requiring chemotherapy treatment within 5 years prior to screening or currently suspected cancer. participation in other clinical trials within 1.5 months prior to screening. requirement for or administration of the following drugs for 1 month prior to screening: erythropoietin, cytostatics, colchicine, cyclosporin a, interferon- γ -1b, bosentan, macitentan, etanercept, sildenafil, imatinib, warfarin, ambrisentan, nintedanib, pirfenidone, hyaluronidase asoxime 1 month prior to screening; glucocorticosteroids and n-acetylcysteine (requirement or 7 days prior to screening) lactase deficiency, lactose intolerance, glucose-galactose malabsorption. signs of a marked uncontrolled concomitant disease, such as disorders of the nervous system, kidney, liver, endocrine system and gastrointestinal tract, which, in the opinion of the investigator, could prevent the patient from participating in the study. positive test for human immunodeficiency virus (hiv), hepatitis b and/or c. alcohol or drug addiction, history of mental illness. severe, decompensated or unstable somatic diseases (any diseases or conditions that threaten the patient's life or impair the patient's prognosis, and make it impossible for him to participate in a clinical trial). patient's unwillingness or inability to comply with protocol procedures (in the opinion of the study physician). pregnancy or breastfeeding period. other conditions that, in the opinion of the study physician, prevent the patient from entering the study.