1. patients who had mechanical ventilation or extracorporeal membrane oxygen (ecmo) for covid-19; 2. current end-organ failure, organ transplantation, or current hospitalization in acute care hospital; 3. contraindications to all of the study interventions; 4. co-enrolment in another interventional trial (co-enrolment in an observational study is permitted); 5. currently pregnant or breastfeeding.

1. patients who had mechanical ventilation or extracorporeal membrane oxygen (ecmo) for covid-19; 2. current end-organ failure, organ transplantation, or current hospitalization in acute care hospital; 3. contraindications to all of the study interventions; 4. co-enrolment in another interventional trial (co-enrolment in an observational study is permitted); 5. currently pregnant or breastfeeding.

patients who had mechanical ventilation or extracorporeal membrane oxygen (ecmo) for covid-19; current end-organ failure, organ transplantation, or current hospitalization in acute care hospital; contraindications to all of the study interventions; co-enrolment in another interventional trial (co-enrolment in an observational study is permitted); currently pregnant or breastfeeding.

patients who had mechanical ventilation or extracorporeal membrane oxygen (ecmo) for covid-19; current end-organ failure, organ transplantation, or current hospitalization in acute care hospital; contraindications to all of the study interventions; co-enrolment in another interventional trial (co-enrolment in an observational study is permitted); currently pregnant or breastfeeding.