* all patients positive for intradermal reaction to polymerized type i collagen (allergy to study producto) will be excluded. * all pregnant or breast-feeding patients, patients with chronic kidney disease as determined by calculating an estimated glomerular filtration rate (egfr), or need for hemodialysis or hemofiltration, patients with cerebrovascular disease, autoimmune disease, cancer, multiorgan failure or immunodeficiencies (hiv, transplant patients, hematological diseases, patients with chemotherapy) will be excluded.

* all patients positive for intradermal reaction to polymerized type i collagen (allergy to study producto) will be excluded. * all pregnant or breast-feeding patients, patients with chronic kidney disease as determined by calculating an estimated glomerular filtration rate (egfr), or need for hemodialysis or hemofiltration, patients with cerebrovascular disease, autoimmune disease, cancer, multiorgan failure or immunodeficiencies (hiv, transplant patients, hematological diseases, patients with chemotherapy) will be excluded.

- all patients positive for intradermal reaction to polymerized type i collagen (allergy to study producto) will be excluded. - all pregnant or breast-feeding patients, patients with chronic kidney disease as determined by calculating an estimated glomerular filtration rate (egfr), or need for hemodialysis or hemofiltration, patients with cerebrovascular disease, autoimmune disease, cancer, multiorgan failure or immunodeficiencies (hiv, transplant patients, hematological diseases, patients with chemotherapy) will be excluded.

- all patients positive for intradermal reaction to polymerized type i collagen (allergy to study producto) will be excluded. - all pregnant or breast-feeding patients, patients with chronic kidney disease as determined by calculating an estimated glomerular filtration rate (egfr), or need for hemodialysis or hemofiltration, patients with cerebrovascular disease, autoimmune disease, cancer, multiorgan failure or immunodeficiencies (hiv, transplant patients, hematological diseases, patients with chemotherapy) will be excluded.