inclusion criteria: * laboratory confirmed sars-cov-2 by positive rt-pcr on any respiratory sample; * age ≥ 18 years; * require hospital admission for covid-19 pneumonia as defined by the presence of pulmonary infiltrates on chest x-ray; * moderate to severe covid-19 disease, defined as: spo2 ≤ 93% on room air; plus requiring non-invasive oxygen therapy (who r\&d bosci 4 or 5 * signed informed consent; * pregnant women will be allowed to participate.

inclusion criteria: * laboratory confirmed sars-cov-2 by positive rt-pcr on any respiratory sample; * age ≥ 18 years; * require hospital admission for covid-19 pneumonia as defined by the presence of pulmonary infiltrates on chest x-ray; * moderate to severe covid-19 disease, defined as: spo2 ≤ 93% on room air; plus requiring non-invasive oxygen therapy (who r\&d bosci 4 or 5 * signed informed consent; * pregnant women will be allowed to participate.

inclusion criteria: - laboratory confirmed sars-cov-2 by positive rt-pcr on any respiratory sample; - age ≥ 18 years; - require hospital admission for covid-19 pneumonia as defined by the presence of pulmonary infiltrates on chest x-ray; - moderate to severe covid-19 disease, defined as: spo2 ≤ 93% on room air; plus requiring non-invasive oxygen therapy (who r&d bosci 4 or 5 - signed informed consent; - pregnant women will be allowed to participate.

inclusion criteria: - laboratory confirmed sars-cov-2 by positive rt-pcr on any respiratory sample; - age ≥ 18 years; - require hospital admission for covid-19 pneumonia as defined by the presence of pulmonary infiltrates on chest x-ray; - moderate to severe covid-19 disease, defined as: spo2 ≤ 93% on room air; plus requiring non-invasive oxygen therapy (who r&d bosci 4 or 5 - signed informed consent; - pregnant women will be allowed to participate.