inclusion criteria: 1. adults of both genders, 18 years of age and older, not older than 55 years of age in part 1. 2. the subject has a bmi (body mass index) ≤30 kg/m2, inclusive, at screening. 3. having understood the contents of the icf and patient information sheet, and having signed the icf. 4. free of obvious health problems as established by medical history including physical examination and clinical judgment of the investigator. 5. clinical laboratory test results within normal reference range, or results with acceptable deviations that are judged to be ncs (not clinically significant) by the investigator. (part 1 only) 6. willing to come to study site and/or to receive home visits for the entire study period. 7. residence in the study area. 8. female subjects of childbearing potential have used available contraceptive methods during their sexual life within 14 days before enrollment, have no pregnancy plan and will take effective contraceptive measures from enrollment to 1 month after the 2nd vaccination.

inclusion criteria: 1. adults of both genders, 18 years of age and older, not older than 55 years of age in part 1. 2. the subject has a bmi (body mass index) ≤30 kg/m2, inclusive, at screening. 3. having understood the contents of the icf and patient information sheet, and having signed the icf. 4. free of obvious health problems as established by medical history including physical examination and clinical judgment of the investigator. 5. clinical laboratory test results within normal reference range, or results with acceptable deviations that are judged to be ncs (not clinically significant) by the investigator. (part 1 only) 6. willing to come to study site and/or to receive home visits for the entire study period. 7. residence in the study area. 8. female subjects of childbearing potential have used available contraceptive methods during their sexual life within 14 days before enrollment, have no pregnancy plan and will take effective contraceptive measures from enrollment to 1 month after the 2nd vaccination.

inclusion criteria: adults of both genders, 18 years of age and older, not older than 55 years of age in part 1. the subject has a bmi (body mass index) ≤30 kg/m2, inclusive, at screening. having understood the contents of the icf and patient information sheet, and having signed the icf. free of obvious health problems as established by medical history including physical examination and clinical judgment of the investigator. clinical laboratory test results within normal reference range, or results with acceptable deviations that are judged to be ncs (not clinically significant) by the investigator. (part 1 only) willing to come to study site and/or to receive home visits for the entire study period. residence in the study area. female subjects of childbearing potential have used available contraceptive methods during their sexual life within 14 days before enrollment, have no pregnancy plan and will take effective contraceptive measures from enrollment to 1 month after the 2nd vaccination.

inclusion criteria: adults of both genders, 18 years of age and older, not older than 55 years of age in part 1. the subject has a bmi (body mass index) ≤30 kg/m2, inclusive, at screening. having understood the contents of the icf and patient information sheet, and having signed the icf. free of obvious health problems as established by medical history including physical examination and clinical judgment of the investigator. clinical laboratory test results within normal reference range, or results with acceptable deviations that are judged to be ncs (not clinically significant) by the investigator. (part 1 only) willing to come to study site and/or to receive home visits for the entire study period. residence in the study area. female subjects of childbearing potential have used available contraceptive methods during their sexual life within 14 days before enrollment, have no pregnancy plan and will take effective contraceptive measures from enrollment to 1 month after the 2nd vaccination.