inclusion criteria: * age greater than or equal to 18 years of age. * admitted to the hospital regional de alta especialidad de zumpango. * confirmed sars-cov-2 infection with either: positive laboratory test for sars-cov-2; or positive ct thorax diagnostic for sars-cov-2 infection according to the prevailing criteria. * hypoxic respiratory failure: spo2 ≤94% on room or tachypnea (respiratory rate ≥22 breaths/min). randomization: * within 24 hours of confirmed in-hospital sars-cov-2 infection diagnosis or * within 24 hours of hospital admission in case of pre-hospital confirmed sars-cov-2 infection. * in case there is a lack of laboratory tests for sars-cov-2 in a potentially eligible patient, a positive laboratory test for sars-cov-2 will be no longer required. in that case, the potentially eligible patient needs to meet the prevailing criteria for the diagnosis of sars-cov-2 infection, such as typical abnormalities on pulmonary ct in the setting of high clinical suspicion of sars-cov-2 infection.

inclusion criteria: * age greater than or equal to 18 years of age. * admitted to the hospital regional de alta especialidad de zumpango. * confirmed sars-cov-2 infection with either: positive laboratory test for sars-cov-2; or positive ct thorax diagnostic for sars-cov-2 infection according to the prevailing criteria. * hypoxic respiratory failure: spo2 ≤94% on room or tachypnea (respiratory rate ≥22 breaths/min). randomization: * within 24 hours of confirmed in-hospital sars-cov-2 infection diagnosis or * within 24 hours of hospital admission in case of pre-hospital confirmed sars-cov-2 infection. * in case there is a lack of laboratory tests for sars-cov-2 in a potentially eligible patient, a positive laboratory test for sars-cov-2 will be no longer required. in that case, the potentially eligible patient needs to meet the prevailing criteria for the diagnosis of sars-cov-2 infection, such as typical abnormalities on pulmonary ct in the setting of high clinical suspicion of sars-cov-2 infection.

inclusion criteria: - age greater than or equal to 18 years of age. - admitted to the hospital regional de alta especialidad de zumpango. - confirmed sars-cov-2 infection with either: positive laboratory test for sars-cov-2; or positive ct thorax diagnostic for sars-cov-2 infection according to the prevailing criteria. - hypoxic respiratory failure: spo2 ≤94% on room or tachypnea (respiratory rate ≥22 breaths/min). randomization: - within 24 hours of confirmed in-hospital sars-cov-2 infection diagnosis or - within 24 hours of hospital admission in case of pre-hospital confirmed sars-cov-2 infection. - in case there is a lack of laboratory tests for sars-cov-2 in a potentially eligible patient, a positive laboratory test for sars-cov-2 will be no longer required. in that case, the potentially eligible patient needs to meet the prevailing criteria for the diagnosis of sars-cov-2 infection, such as typical abnormalities on pulmonary ct in the setting of high clinical suspicion of sars-cov-2 infection.

inclusion criteria: - age greater than or equal to 18 years of age. - admitted to the hospital regional de alta especialidad de zumpango. - confirmed sars-cov-2 infection with either: positive laboratory test for sars-cov-2; or positive ct thorax diagnostic for sars-cov-2 infection according to the prevailing criteria. - hypoxic respiratory failure: spo2 ≤94% on room or tachypnea (respiratory rate ≥22 breaths/min). randomization: - within 24 hours of confirmed in-hospital sars-cov-2 infection diagnosis or - within 24 hours of hospital admission in case of pre-hospital confirmed sars-cov-2 infection. - in case there is a lack of laboratory tests for sars-cov-2 in a potentially eligible patient, a positive laboratory test for sars-cov-2 will be no longer required. in that case, the potentially eligible patient needs to meet the prevailing criteria for the diagnosis of sars-cov-2 infection, such as typical abnormalities on pulmonary ct in the setting of high clinical suspicion of sars-cov-2 infection.